IL183702A0 - Difluoronucleosides and process for preparation thereof - Google Patents

Difluoronucleosides and process for preparation thereof

Info

Publication number
IL183702A0
IL183702A0 IL183702A IL18370207A IL183702A0 IL 183702 A0 IL183702 A0 IL 183702A0 IL 183702 A IL183702 A IL 183702A IL 18370207 A IL18370207 A IL 18370207A IL 183702 A0 IL183702 A0 IL 183702A0
Authority
IL
Israel
Prior art keywords
difluoronucleosides
preparation
Prior art date
Application number
IL183702A
Other languages
English (en)
Original Assignee
Sicor Inc
Born Ann Ruth
Martin Pierre
Spielvogel Dirk
Villa Marco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc, Born Ann Ruth, Martin Pierre, Spielvogel Dirk, Villa Marco filed Critical Sicor Inc
Publication of IL183702A0 publication Critical patent/IL183702A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL183702A 2004-12-08 2007-06-05 Difluoronucleosides and process for preparation thereof IL183702A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63437604P 2004-12-08 2004-12-08
PCT/US2005/044369 WO2006063105A1 (en) 2004-12-08 2005-12-08 Difluoronucleosides and process for preparation thereof

Publications (1)

Publication Number Publication Date
IL183702A0 true IL183702A0 (en) 2007-09-20

Family

ID=36147231

Family Applications (1)

Application Number Title Priority Date Filing Date
IL183702A IL183702A0 (en) 2004-12-08 2007-06-05 Difluoronucleosides and process for preparation thereof

Country Status (10)

Country Link
US (1) US20060173174A1 (enExample)
EP (1) EP1819718A1 (enExample)
JP (1) JP2007522151A (enExample)
KR (1) KR20070073958A (enExample)
CN (1) CN101076535A (enExample)
CA (1) CA2586687A1 (enExample)
IL (1) IL183702A0 (enExample)
MX (1) MX2007006837A (enExample)
TW (1) TW200634022A (enExample)
WO (1) WO2006063105A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain Compounds, Compositions and Methods
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
TWI477508B (zh) 2009-04-06 2015-03-21 Otsuka Pharma Co Ltd 用以治療癌症之組成物及方法
EP2416781B1 (en) 2009-04-06 2017-03-08 Otsuka Pharmaceutical Co., Ltd. Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer
UY32546A (es) 2009-04-06 2010-10-29 Eisai Inc Composiciones y metodos para tratar cancer
CN105693795A (zh) * 2014-08-13 2016-06-22 陈欣 能破坏细胞复制的二氟代核苷类抗癌药的制备方法
WO2025235664A1 (en) * 2024-05-07 2025-11-13 Emory University Purine nucleotide and nucleoside therapeutic compositions and uses related thereto
CN121949418B (zh) * 2026-04-01 2026-07-28 山东安弘制药有限公司 一种盐酸吉西他滨的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU452961A3 (ru) * 1969-04-11 1974-12-05 Шеринг Аг. (Фирма) Способ получени пиримидиннуклеозидов
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
DE3587500T2 (de) * 1984-12-04 1993-12-16 Lilly Co Eli Tumorbehandlung bei Säugetieren.
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
BR9302431A (pt) * 1992-06-22 1994-01-11 Lilly Co Eli Processo de glicosilacao de anion estereosseletivo
US5594124A (en) * 1992-06-22 1997-01-14 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US6828346B2 (en) * 1999-10-25 2004-12-07 Supergen, Inc. Methods for administration of paclitaxel
WO2004041203A2 (en) * 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
CN1228342C (zh) * 2003-04-08 2005-11-23 深圳市汉德森技术有限公司 以1，6－脱水－β－D－葡萄糖为原料制备2'－脱氧－2'，2'－二氟－β－核胞苷或其药用盐的方法

Also Published As

Publication number Publication date
EP1819718A1 (en) 2007-08-22
US20060173174A1 (en) 2006-08-03
WO2006063105A1 (en) 2006-06-15
JP2007522151A (ja) 2007-08-09
CA2586687A1 (en) 2006-06-15
MX2007006837A (es) 2007-10-23
CN101076535A (zh) 2007-11-21
KR20070073958A (ko) 2007-07-10
TW200634022A (en) 2006-10-01

Similar Documents

Publication Publication Date Title
TWI340137B (en) Preparation process
GB0416001D0 (en) Process
GB0407329D0 (en) Process
GB0418654D0 (en) Process
GB0418046D0 (en) Eantioselective process
GB0413053D0 (en) Process
GB0419075D0 (en) Process
ZA200803987B (en) Novel process and formulations
GB0404793D0 (en) Process
GB0414847D0 (en) Process
GB0417263D0 (en) Process and system
GB0406894D0 (en) Process
GB0410289D0 (en) Process
ZA200704714B (en) Integrated separation and preparation process
ZA200704715B (en) Integrated preparation and separation process
GB0423746D0 (en) Process and polymorphs prepared thereby
GB0412875D0 (en) Process
GB0414335D0 (en) Process
IL182970A0 (en) Compositions and processes for preparing 13-deoxy-anthracyclines
GB0403696D0 (en) Process and composition
GB0411583D0 (en) Process
GB0411185D0 (en) Process
GB0408156D0 (en) Process and compounds
GB0420561D0 (en) Process
GB0406069D0 (en) Process