TW200633712A - Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof - Google Patents
Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereofInfo
- Publication number
- TW200633712A TW200633712A TW094141323A TW94141323A TW200633712A TW 200633712 A TW200633712 A TW 200633712A TW 094141323 A TW094141323 A TW 094141323A TW 94141323 A TW94141323 A TW 94141323A TW 200633712 A TW200633712 A TW 200633712A
- Authority
- TW
- Taiwan
- Prior art keywords
- receptor
- compounds
- chromanylurea
- inhibit vanilloid
- subtype
- Prior art date
Links
- 108010025083 TRPV1 receptor Proteins 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 102100029613 Transient receptor potential cation channel subfamily V member 1 Human genes 0.000 title 2
- 102000005962 receptors Human genes 0.000 title 1
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63063604P | 2004-11-24 | 2004-11-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200633712A true TW200633712A (en) | 2006-10-01 |
Family
ID=36588346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094141323A TW200633712A (en) | 2004-11-24 | 2005-11-24 | Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7812019B2 (enExample) |
| EP (2) | EP1844038A2 (enExample) |
| JP (2) | JP4932730B2 (enExample) |
| KR (2) | KR101250824B1 (enExample) |
| CN (2) | CN102161653A (enExample) |
| AU (1) | AU2005316972B2 (enExample) |
| BR (1) | BRPI0518581A2 (enExample) |
| CA (1) | CA2588909A1 (enExample) |
| IL (1) | IL183321A0 (enExample) |
| MX (1) | MX2007006205A (enExample) |
| NZ (1) | NZ555318A (enExample) |
| TW (1) | TW200633712A (enExample) |
| WO (1) | WO2006065484A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005086331A2 (en) * | 2004-03-02 | 2005-09-15 | Rosemount, Inc. | Process device with improved power generation |
| US8538560B2 (en) | 2004-04-29 | 2013-09-17 | Rosemount Inc. | Wireless power and communication unit for process field devices |
| US8145180B2 (en) * | 2004-05-21 | 2012-03-27 | Rosemount Inc. | Power generation for process devices |
| CN102161653A (zh) * | 2004-11-24 | 2011-08-24 | 雅培制药有限公司 | 抑制香草素受体亚型1(vr1)受体的苯并二氢吡喃基脲化合物及其用途 |
| WO2006078697A1 (en) * | 2005-01-18 | 2006-07-27 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid receptor modulators |
| MX2007013163A (es) * | 2005-04-22 | 2008-01-21 | Wyeth Corp | Derivados de cromano y cromeno y usos de los mismos. |
| KR20080067361A (ko) * | 2005-10-28 | 2008-07-18 | 아보트 러보러터리즈 | Ｔｒｐｖ1 수용체를 억제하는 인다졸 유도체 |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| RU2450006C2 (ru) * | 2006-04-18 | 2012-05-10 | Эбботт Лэборетриз | Антагонисты ванилоидного рецептора подтипа 1(vr1) и их применение |
| US7913566B2 (en) | 2006-05-23 | 2011-03-29 | Rosemount Inc. | Industrial process device utilizing magnetic induction |
| WO2008059339A2 (en) * | 2006-11-13 | 2008-05-22 | Glenmark Pharmaceuticals S.A. | Isoquinoline derivatives as vanilloid receptor modulators |
| CA2672196A1 (en) * | 2006-12-20 | 2008-07-03 | Abbott Laboratories | Antagonists of the trpv1 receptor and uses thereof |
| WO2008110863A1 (en) * | 2007-03-15 | 2008-09-18 | Glenmark Pharmaceuticals S.A. | Indazole derivatives and their use as vanilloid receptor ligands |
| PE20091102A1 (es) | 2007-12-17 | 2009-07-25 | Janssen Pharmaceutica Nv | Moduladores imidazolo-, oxazolo-, y tiazolopirimidina del trpv1 |
| WO2009095726A1 (en) * | 2008-01-29 | 2009-08-06 | Glenmark Pharmaceuticals, S.A. | Acrylamide derivatives as vanilloid receptor 1 modulators |
| JP5305704B2 (ja) * | 2008-03-24 | 2013-10-02 | 富士フイルム株式会社 | 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版 |
| US8250924B2 (en) | 2008-04-22 | 2012-08-28 | Rosemount Inc. | Industrial process device utilizing piezoelectric transducer |
| US8847571B2 (en) * | 2008-06-17 | 2014-09-30 | Rosemount Inc. | RF adapter for field device with variable voltage drop |
| CN102084307B (zh) | 2008-06-17 | 2014-10-29 | 罗斯蒙特公司 | 用于具有低压本质安全钳的现场设备的rf适配器 |
| US8929948B2 (en) | 2008-06-17 | 2015-01-06 | Rosemount Inc. | Wireless communication adapter for field devices |
| US8694060B2 (en) | 2008-06-17 | 2014-04-08 | Rosemount Inc. | Form factor and electromagnetic interference protection for process device wireless adapters |
| WO2010023512A1 (en) * | 2008-08-28 | 2010-03-04 | Matrix Laboratories Ltd. | Novel vanilloid receptor modulators, process for their preparation and pharmaceutical compositions containing them |
| CA2737775A1 (en) * | 2008-10-17 | 2010-04-22 | Abbott Laboratories | Trpv1 antagonists |
| US8604053B2 (en) * | 2008-10-17 | 2013-12-10 | Abbvie Inc. | TRPV1 antagonists |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| CN101654435B (zh) * | 2009-06-09 | 2014-01-29 | 沈阳药科大学 | N-苯甲基喹啉羧酸类化合物、组合物及其制备方法 |
| US20100318007A1 (en) * | 2009-06-10 | 2010-12-16 | O'brien Donald J | Electromechanical tactile stimulation devices and methods |
| US9674976B2 (en) | 2009-06-16 | 2017-06-06 | Rosemount Inc. | Wireless process communication adapter with improved encapsulation |
| US8626087B2 (en) | 2009-06-16 | 2014-01-07 | Rosemount Inc. | Wire harness for field devices used in a hazardous locations |
| US8648086B2 (en) | 2009-08-24 | 2014-02-11 | Ascepion Pharmaceuticals, Inc. | 5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors |
| US20120295942A1 (en) | 2010-02-01 | 2012-11-22 | Nicholas James Devereux | Pyrazolo[5,1b]oxazole Derivatives as CRF-1 Receptor Antagonists |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| CN102753527B (zh) | 2010-02-02 | 2014-12-24 | 诺华股份有限公司 | 用作crf受体拮抗剂的环己基酰胺衍生物 |
| US8598156B2 (en) | 2010-03-25 | 2013-12-03 | Glaxosmithkline Llc | Chemical compounds |
| US10761524B2 (en) | 2010-08-12 | 2020-09-01 | Rosemount Inc. | Wireless adapter with process diagnostics |
| CN103635458B (zh) | 2011-03-25 | 2016-10-19 | 艾伯维公司 | Trpv1拮抗剂 |
| US9310794B2 (en) | 2011-10-27 | 2016-04-12 | Rosemount Inc. | Power supply for industrial process field device |
| US8859584B2 (en) | 2011-12-19 | 2014-10-14 | Abbvie, Inc. | TRPV1 antagonists |
| US8969325B2 (en) | 2011-12-19 | 2015-03-03 | Abbvie Inc. | TRPV1 antagonists |
| US8796328B2 (en) | 2012-06-20 | 2014-08-05 | Abbvie Inc. | TRPV1 antagonists |
| CN103739547B (zh) * | 2014-01-03 | 2015-09-02 | 沈阳药科大学 | 2-[6-甲氧基-3-(2,3-二氯苯基)甲基-4-氧代-1,4-二氢-1(4h)-喹啉基]乙酸的合成方法 |
| US9783527B2 (en) * | 2014-09-16 | 2017-10-10 | Abbvie Inc. | Indazole ureas and method of use |
| CN109574972A (zh) * | 2018-07-13 | 2019-04-05 | 郑州大学 | 一种3-烷基取代-4-色满酮类化合物及其制备方法 |
| US20240025856A1 (en) * | 2020-09-30 | 2024-01-25 | Katholieke Universiteit Leuven | 1,2,3,4-tetrahydroquinoline derivatives as inhibitors of the yap/taz-tead activation for treating cancer |
| WO2025161263A1 (zh) * | 2024-01-31 | 2025-08-07 | 深圳晶蛋生物医药科技有限公司 | 一种苯并吗啉类化合物及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8900565A (nl) | 1989-03-08 | 1990-10-01 | Philips Nv | Methode voor de verwerking van een radio data signaal, alsmede ontvanger voor de uitvoering van deze methode. |
| EP0386839B1 (en) * | 1989-03-08 | 1997-01-15 | Merck Sharp & Dohme Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
| US5374643A (en) * | 1992-09-11 | 1994-12-20 | E. R. Squibb & Sons, Inc. | Aryl urea (thiourea) and cyanoguanidine derivatives |
| EP0922028A1 (en) * | 1996-08-26 | 1999-06-16 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
| CA2389360C (en) | 1999-11-16 | 2008-06-03 | Steffen Breitfelder | Urea derivatives as anti-inflammatory agents |
| CA2486092A1 (en) * | 2002-05-17 | 2003-11-27 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid vr1 receptor |
| US7514562B2 (en) * | 2003-03-07 | 2009-04-07 | Glaxo Group Limited | Urea derivatives and their use as vanilloid receptor antagonists in the treatment of pain |
| CN102161653A (zh) * | 2004-11-24 | 2011-08-24 | 雅培制药有限公司 | 抑制香草素受体亚型1(vr1)受体的苯并二氢吡喃基脲化合物及其用途 |
| KR20080067361A (ko) * | 2005-10-28 | 2008-07-18 | 아보트 러보러터리즈 | Ｔｒｐｖ1 수용체를 억제하는 인다졸 유도체 |
-
2005
- 2005-11-22 CN CN2011100508496A patent/CN102161653A/zh active Pending
- 2005-11-22 NZ NZ555318A patent/NZ555318A/en not_active IP Right Cessation
- 2005-11-22 JP JP2007543471A patent/JP4932730B2/ja not_active Expired - Fee Related
- 2005-11-22 EP EP05825417A patent/EP1844038A2/en not_active Withdrawn
- 2005-11-22 KR KR1020077014371A patent/KR101250824B1/ko not_active Expired - Fee Related
- 2005-11-22 BR BRPI0518581-5A patent/BRPI0518581A2/pt not_active IP Right Cessation
- 2005-11-22 EP EP12181173A patent/EP2527339A1/en not_active Withdrawn
- 2005-11-22 US US11/285,448 patent/US7812019B2/en not_active Expired - Fee Related
- 2005-11-22 CA CA002588909A patent/CA2588909A1/en not_active Abandoned
- 2005-11-22 WO PCT/US2005/042545 patent/WO2006065484A2/en not_active Ceased
- 2005-11-22 KR KR1020127028557A patent/KR20120137420A/ko not_active Withdrawn
- 2005-11-22 AU AU2005316972A patent/AU2005316972B2/en not_active Ceased
- 2005-11-22 CN CNA2005800467732A patent/CN101443327A/zh active Pending
- 2005-11-22 MX MX2007006205A patent/MX2007006205A/es active IP Right Grant
- 2005-11-24 TW TW094141323A patent/TW200633712A/zh unknown
-
2007
- 2007-05-20 IL IL183321A patent/IL183321A0/en unknown
-
2010
- 2010-09-03 US US12/875,839 patent/US8440691B2/en not_active Expired - Fee Related
-
2012
- 2012-01-11 JP JP2012003232A patent/JP2012111766A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US7812019B2 (en) | 2010-10-12 |
| JP2012111766A (ja) | 2012-06-14 |
| US20110152250A1 (en) | 2011-06-23 |
| IL183321A0 (en) | 2008-04-13 |
| EP1844038A2 (en) | 2007-10-17 |
| AU2005316972A1 (en) | 2006-06-22 |
| JP4932730B2 (ja) | 2012-05-16 |
| US20060128689A1 (en) | 2006-06-15 |
| JP2008532925A (ja) | 2008-08-21 |
| CA2588909A1 (en) | 2006-06-22 |
| US8440691B2 (en) | 2013-05-14 |
| CN102161653A (zh) | 2011-08-24 |
| KR20120137420A (ko) | 2012-12-20 |
| CN101443327A (zh) | 2009-05-27 |
| MX2007006205A (es) | 2009-02-13 |
| NZ555318A (en) | 2011-01-28 |
| EP2527339A1 (en) | 2012-11-28 |
| WO2006065484A3 (en) | 2009-02-19 |
| KR20070086607A (ko) | 2007-08-27 |
| BRPI0518581A2 (pt) | 2008-11-25 |
| WO2006065484A2 (en) | 2006-06-22 |
| AU2005316972B2 (en) | 2011-11-10 |
| KR101250824B1 (ko) | 2013-04-05 |
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