TW200621795A - 15β-substituted steroids having selective estrogenic activity - Google Patents

15β-substituted steroids having selective estrogenic activity

Info

Publication number
TW200621795A
TW200621795A TW094130148A TW94130148A TW200621795A TW 200621795 A TW200621795 A TW 200621795A TW 094130148 A TW094130148 A TW 094130148A TW 94130148 A TW94130148 A TW 94130148A TW 200621795 A TW200621795 A TW 200621795A
Authority
TW
Taiwan
Prior art keywords
estrogenic activity
substituted steroids
5alkyl
selective estrogenic
substituted
Prior art date
Application number
TW094130148A
Other languages
English (en)
Inventor
Hubert Jan Jozef Loozen
Antonius Gerardus Hendrikus Ederveen
Fredericus Antonius Dijcks
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of TW200621795A publication Critical patent/TW200621795A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW094130148A 2004-09-08 2005-09-02 15β-substituted steroids having selective estrogenic activity TW200621795A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04104334 2004-09-08

Publications (1)

Publication Number Publication Date
TW200621795A true TW200621795A (en) 2006-07-01

Family

ID=34929554

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094130148A TW200621795A (en) 2004-09-08 2005-09-02 15β-substituted steroids having selective estrogenic activity

Country Status (20)

Country Link
US (1) US7838516B2 (zh)
EP (1) EP1805201B1 (zh)
JP (1) JP4889644B2 (zh)
AR (1) AR050732A1 (zh)
AT (1) ATE414710T1 (zh)
AU (1) AU2005281705B2 (zh)
BR (1) BRPI0514976A (zh)
CA (1) CA2577497C (zh)
DK (1) DK1805201T3 (zh)
ES (1) ES2317312T3 (zh)
NZ (1) NZ553266A (zh)
PE (1) PE20060590A1 (zh)
PL (1) PL1805201T3 (zh)
PT (1) PT1805201E (zh)
RS (1) RS51640B (zh)
RU (1) RU2386637C2 (zh)
SI (1) SI1805201T1 (zh)
TW (1) TW200621795A (zh)
UA (1) UA89964C2 (zh)
WO (1) WO2006027347A1 (zh)

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US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
US8080540B2 (en) 2006-09-19 2011-12-20 Abbott Products Gmbh Therapeutically active triazoles and their use
US8288367B2 (en) 2006-11-30 2012-10-16 Solvay Pharmaceuticals Gmbh Substituted estratriene derivatives as 17BETA HSD inhibitors
CA2765609A1 (en) * 2009-06-29 2011-01-06 Merz Pharma Gmbh & Co. Kgaa Method of preparing neramexane
US20130123541A1 (en) * 2009-06-29 2013-05-16 Merz Pharma Gmbh & Co. Kgaa Method of preparing 3,3,5,5-tetramethylcyclohexanone
JP5738854B2 (ja) * 2009-06-29 2015-06-24 メルツ・ファルマ・ゲーエムベーハー・ウント・コ・カーゲーアーアー ネラメキサンの製造方法
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
US8987484B2 (en) * 2011-10-07 2015-03-24 Estetra S.P.R.L. Process for the production of estetrol
EA201690077A1 (ru) 2013-06-25 2016-09-30 Форендо Фарма Лтд. Терапевтически активные производные эстратриен-тиазола
JP6456373B2 (ja) 2013-06-25 2019-01-23 フォレンド ファーマ リミテッド １７β−ヒドロキシステロイドデヒドロゲナーゼ タイプ１の阻害剤として治療活性のあるエストラトリエンチアゾール誘導体
EP3013845B1 (en) 2013-06-25 2020-03-18 Forendo Pharma Ltd Therapeutically active estratrienthiazole derivatives as inhibitors of 17b-hydroxysteroid dehydrogenase, type 1
US10413557B2 (en) 2014-12-23 2019-09-17 Forendo Pharma Ltd. Prodrugs of 17.BETA.-HSD1-inhibitors
JP6545266B2 (ja) 2014-12-23 2019-07-17 フォレンド ファーマ リミテッド １７β‐ＨＳＤ１抑制剤のプロドラッグ
DK3310345T3 (da) 2015-06-18 2021-05-25 Estetra Sprl Orodispersibel tablet indeholdende estetrol
EP3310346B1 (en) 2015-06-18 2021-03-24 Estetra SPRL Orodispersible tablet containing estetrol
UA123098C2 (uk) 2015-06-18 2021-02-17 Естетра Спрл Диспергована у порожнині рота одиниця дозування, що містить естетрольний компонент
EA035687B1 (ru) 2015-06-18 2020-07-27 Эстетра Спрл Диспергируемая в полости рта единица дозирования, содержащая эстетрольный компонент
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
IL294140B2 (en) 2017-06-08 2024-09-01 Forendo Pharma Ltd 15beta-(3-propanamido)-converted ester-1, 3, 5(10)-triane-17-oximes used in the inhibition of 17beta-hydroxysteroid dehydrogenases
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
BR112021010598A2 (pt) 2018-12-05 2021-08-24 Forendo Pharma Ltd Compostos, método para preparação de um composto e composição farmacêutica

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US3257429A (en) * 1957-11-12 1966-06-21 Syntex Corp 16-methylene derivatives of estrone and estradiol
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CZ293319B6 (cs) 1998-06-19 2004-04-14 Akzo Nobel N. V. Derivát testosteronu a farmaceutický prostředek s jeho obsahem
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TW548277B (en) 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
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Also Published As

Publication number Publication date
WO2006027347A1 (en) 2006-03-16
RS20070075A (en) 2008-09-29
US20070254860A1 (en) 2007-11-01
RS51640B (en) 2011-10-31
NZ553266A (en) 2009-06-26
EP1805201A1 (en) 2007-07-11
DK1805201T3 (da) 2009-01-12
JP4889644B2 (ja) 2012-03-07
SI1805201T1 (sl) 2009-04-30
RU2007112939A (ru) 2008-11-10
US7838516B2 (en) 2010-11-23
EP1805201B1 (en) 2008-11-19
PE20060590A1 (es) 2006-07-14
PT1805201E (pt) 2008-12-31
AR050732A1 (es) 2006-11-15
JP2008512426A (ja) 2008-04-24
AU2005281705B2 (en) 2011-03-10
PL1805201T3 (pl) 2009-04-30
UA89964C2 (ru) 2010-03-25
ATE414710T1 (de) 2008-12-15
BRPI0514976A (pt) 2008-07-01
AU2005281705A1 (en) 2006-03-16
CA2577497A1 (en) 2006-03-16
RU2386637C2 (ru) 2010-04-20
CA2577497C (en) 2012-03-20
ES2317312T3 (es) 2009-04-16

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