TW200500357A - Method for the synthesis of a benzimidazole compound - Google Patents

Method for the synthesis of a benzimidazole compound

Info

Publication number
TW200500357A
TW200500357A TW092128112A TW92128112A TW200500357A TW 200500357 A TW200500357 A TW 200500357A TW 092128112 A TW092128112 A TW 092128112A TW 92128112 A TW92128112 A TW 92128112A TW 200500357 A TW200500357 A TW 200500357A
Authority
TW
Taiwan
Prior art keywords
synthesis
carried out
benzimidazole compound
reaction sequence
whole reaction
Prior art date
Application number
TW092128112A
Other languages
English (en)
Other versions
TWI310382B (en
Inventor
Anders Gustavsson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20289310&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200500357(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of TW200500357A publication Critical patent/TW200500357A/zh
Application granted granted Critical
Publication of TWI310382B publication Critical patent/TWI310382B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW092128112A 2002-10-18 2003-10-09 Method for the synthesis of a benzimidazole compound TWI310382B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0203092A SE0203092D0 (en) 2002-10-18 2002-10-18 Method for the synthesis of a benzimidazole compound

Publications (2)

Publication Number Publication Date
TW200500357A true TW200500357A (en) 2005-01-01
TWI310382B TWI310382B (en) 2009-06-01

Family

ID=20289310

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092128112A TWI310382B (en) 2002-10-18 2003-10-09 Method for the synthesis of a benzimidazole compound

Country Status (32)

Country Link
US (2) US7227024B2 (zh)
EP (1) EP1556370B1 (zh)
JP (1) JP4551221B2 (zh)
KR (1) KR101065885B1 (zh)
CN (2) CN101230057B (zh)
AR (1) AR041639A1 (zh)
AT (1) ATE398118T1 (zh)
AU (1) AU2003269773B2 (zh)
BR (1) BR0315254A (zh)
CA (1) CA2501542C (zh)
CY (1) CY1108255T1 (zh)
DE (1) DE60321588D1 (zh)
DK (1) DK1556370T3 (zh)
ES (1) ES2306883T3 (zh)
HK (1) HK1078852A1 (zh)
IL (1) IL167795A (zh)
IS (1) IS2590B (zh)
MX (1) MXPA05003994A (zh)
MY (1) MY133573A (zh)
NO (1) NO330785B1 (zh)
NZ (1) NZ539370A (zh)
PL (1) PL376819A1 (zh)
PT (1) PT1556370E (zh)
RU (1) RU2324691C2 (zh)
SA (1) SA03240344B1 (zh)
SE (1) SE0203092D0 (zh)
SI (1) SI1556370T1 (zh)
TW (1) TWI310382B (zh)
UA (1) UA79147C2 (zh)
UY (1) UY28025A1 (zh)
WO (1) WO2004035565A1 (zh)
ZA (1) ZA200502577B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111943883A (zh) * 2020-08-21 2020-11-17 抚州三和医药化工有限公司 一种奥美氯化物的生产工艺

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
US8691995B2 (en) 2004-12-16 2014-04-08 Cipla Limited Process
WO2010134099A1 (en) 2009-05-21 2010-11-25 Cadila Healthcare Limited One pot process for preparing omeprazole and related compounds
SG181535A1 (en) 2009-12-08 2012-07-30 Codexis Inc Synthesis of prazole compounds
US9267159B2 (en) 2010-12-08 2016-02-23 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
CN103570681A (zh) * 2012-07-24 2014-02-12 江苏柯菲平医药有限公司 一种埃索美拉唑关键中间体的制备方法
CN103232389A (zh) * 2013-05-08 2013-08-07 浙江新三和医药化工股份有限公司 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的制备方法
CN103524494A (zh) * 2013-11-07 2014-01-22 安徽国星生物化学有限公司 含甲基吡啶基团的巯基咪唑类衍生物及合成方法
CN108251466B (zh) * 2016-12-28 2021-07-02 浙江京新药业股份有限公司 一种酶法合成埃索美拉唑的方法
CN107400118B (zh) * 2017-08-29 2020-07-28 信泰制药（苏州）有限公司 埃索美拉唑中间体的制备方法
KR20220084718A (ko) 2020-12-14 2022-06-21 메디케어제약 주식회사 기능성 소화 불량을 동반한 위식도 역류 질환을 치료하는 약제학적 복합제제
KR20230090184A (ko) 2021-12-14 2023-06-21 메디케어제약 주식회사 에스오메프라졸 및 레바미피드를 포함하는 약제학적 복합제제

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4619997A (en) 1984-09-06 1986-10-28 The Upjohn Company Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents
SE9002043D0 (sv) 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
NZ244301A (en) 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
CN1080721C (zh) * 1995-07-03 2002-03-13 旭化成株式会社 1－(5－异喹啉磺酰基)高哌嗪盐酸盐水合物
SE521100C2 (sv) 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
SE9704183D0 (sv) * 1997-11-14 1997-11-14 Astra Ab New process
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111943883A (zh) * 2020-08-21 2020-11-17 抚州三和医药化工有限公司 一种奥美氯化物的生产工艺

Also Published As

Publication number Publication date
CN101230057A (zh) 2008-07-30
RU2005109270A (ru) 2006-01-20
AR041639A1 (es) 2005-05-26
CN1705656A (zh) 2005-12-07
DE60321588D1 (de) 2008-07-24
MY133573A (en) 2007-11-30
RU2324691C2 (ru) 2008-05-20
NO20052158L (no) 2005-05-02
MXPA05003994A (es) 2005-06-22
WO2004035565A8 (en) 2005-05-19
WO2004035565A1 (en) 2004-04-29
NZ539370A (en) 2006-11-30
UY28025A1 (es) 2004-05-31
UA79147C2 (en) 2007-05-25
AU2003269773B2 (en) 2007-02-01
US7683178B2 (en) 2010-03-23
BR0315254A (pt) 2005-08-23
SE0203092D0 (en) 2002-10-18
AU2003269773A1 (en) 2004-05-04
JP4551221B2 (ja) 2010-09-22
TWI310382B (en) 2009-06-01
SA03240344B1 (ar) 2008-09-14
EP1556370A1 (en) 2005-07-27
US7227024B2 (en) 2007-06-05
ATE398118T1 (de) 2008-07-15
HK1078852A1 (en) 2006-03-24
IL167795A (en) 2011-02-28
US20060084811A1 (en) 2006-04-20
PT1556370E (pt) 2008-08-06
IS7834A (is) 2005-05-03
NO330785B1 (no) 2011-07-18
ZA200502577B (en) 2005-10-12
CA2501542C (en) 2011-12-06
ES2306883T3 (es) 2008-11-16
PL376819A1 (pl) 2006-01-09
US20080004447A1 (en) 2008-01-03
KR101065885B1 (ko) 2011-09-19
CN100374436C (zh) 2008-03-12
CN101230057B (zh) 2011-09-14
JP2006505567A (ja) 2006-02-16
IS2590B (is) 2010-02-15
CA2501542A1 (en) 2004-04-29
DK1556370T3 (da) 2008-09-01
EP1556370B1 (en) 2008-06-11
SI1556370T1 (sl) 2008-10-31
CY1108255T1 (el) 2014-02-12
KR20050050145A (ko) 2005-05-27

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees