TW200418853A - Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics - Google Patents
Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics Download PDFInfo
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- TW200418853A TW200418853A TW092129284A TW92129284A TW200418853A TW 200418853 A TW200418853 A TW 200418853A TW 092129284 A TW092129284 A TW 092129284A TW 92129284 A TW92129284 A TW 92129284A TW 200418853 A TW200418853 A TW 200418853A
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- 239000003814 drug Substances 0.000 title claims abstract description 7
- 125000000623 heterocyclic group Chemical group 0.000 title claims abstract description 5
- 238000002360 preparation method Methods 0.000 title abstract description 22
- YNHGMRWHXVMPEN-UHFFFAOYSA-N pyrrolo[2,3-f]quinolin-2-one Chemical group C1=CC=C2C3=NC(=O)C=C3C=CC2=N1 YNHGMRWHXVMPEN-UHFFFAOYSA-N 0.000 title abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 31
- -1 N-oxidopyridinio Chemical class 0.000 claims abstract description 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 13
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 8
- 125000005843 halogen group Chemical group 0.000 claims abstract description 7
- 125000001041 indolyl group Chemical group 0.000 claims abstract description 5
- 125000003226 pyrazolyl group Chemical group 0.000 claims abstract description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 4
- 239000001257 hydrogen Substances 0.000 claims abstract description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 4
- 125000002950 monocyclic group Chemical group 0.000 claims abstract description 4
- 125000004076 pyridyl group Chemical group 0.000 claims abstract description 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 4
- 125000002541 furyl group Chemical group 0.000 claims abstract description 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims abstract description 3
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- 150000001875 compounds Chemical class 0.000 claims description 102
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- 238000000034 method Methods 0.000 claims description 14
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- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 239000012453 solvate Substances 0.000 claims description 12
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- 150000002148 esters Chemical class 0.000 claims description 6
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0213270A FR2846330B1 (fr) | 2002-10-23 | 2002-10-23 | Derives de pyridoindolone substitues en -3 par groupe heterocyclique, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200418853A true TW200418853A (en) | 2004-10-01 |
Family
ID=32088226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW092129284A TW200418853A (en) | 2002-10-23 | 2003-10-22 | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1556380B1 (enExample) |
| JP (1) | JP4599164B2 (enExample) |
| AR (1) | AR041690A1 (enExample) |
| AT (1) | ATE323091T1 (enExample) |
| AU (1) | AU2003292285A1 (enExample) |
| CY (1) | CY1105158T1 (enExample) |
| DE (1) | DE60304596T2 (enExample) |
| DK (1) | DK1556380T3 (enExample) |
| ES (1) | ES2263033T3 (enExample) |
| FR (1) | FR2846330B1 (enExample) |
| PT (1) | PT1556380E (enExample) |
| TW (1) | TW200418853A (enExample) |
| WO (1) | WO2004037821A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2823975B1 (fr) | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | Nouvelle utilisation de pyridoindolone |
| FR2846329B1 (fr) | 2002-10-23 | 2004-12-03 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique |
| FR2869316B1 (fr) | 2004-04-21 | 2006-06-02 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique. |
| FR2892416B1 (fr) * | 2005-10-20 | 2008-06-27 | Sanofi Aventis Sa | Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique |
| KR102660608B1 (ko) * | 2019-02-01 | 2024-04-26 | 지앙수 아오사이캉 파마수티칼 씨오., 엘티디. | c-Met억제제로서 피리미디닐기를 포함하는 삼환식 화합물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4263304A (en) * | 1978-06-05 | 1981-04-21 | Sumitomo Chemical Company, Limited | 7 H-indolo[2,3-c]isoquinolines |
| FR2765582B1 (fr) * | 1997-07-03 | 1999-08-06 | Synthelabo | Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique |
| FR2765581B1 (fr) * | 1997-07-03 | 1999-08-06 | Synthelabo | Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique |
-
2002
- 2002-10-23 FR FR0213270A patent/FR2846330B1/fr not_active Expired - Fee Related
-
2003
- 2003-10-21 DE DE60304596T patent/DE60304596T2/de not_active Expired - Lifetime
- 2003-10-21 EP EP03767851A patent/EP1556380B1/fr not_active Expired - Lifetime
- 2003-10-21 PT PT03767851T patent/PT1556380E/pt unknown
- 2003-10-21 AT AT03767851T patent/ATE323091T1/de active
- 2003-10-21 ES ES03767851T patent/ES2263033T3/es not_active Expired - Lifetime
- 2003-10-21 DK DK03767851T patent/DK1556380T3/da active
- 2003-10-21 AU AU2003292285A patent/AU2003292285A1/en not_active Abandoned
- 2003-10-21 WO PCT/FR2003/003111 patent/WO2004037821A1/fr not_active Ceased
- 2003-10-21 JP JP2004546105A patent/JP4599164B2/ja not_active Expired - Fee Related
- 2003-10-22 AR ARP030103841A patent/AR041690A1/es unknown
- 2003-10-22 TW TW092129284A patent/TW200418853A/zh unknown
-
2006
- 2006-07-12 CY CY20061100971T patent/CY1105158T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2263033T3 (es) | 2006-12-01 |
| CY1105158T1 (el) | 2010-03-03 |
| FR2846330A1 (fr) | 2004-04-30 |
| DE60304596D1 (de) | 2006-05-24 |
| AU2003292285A1 (en) | 2004-05-13 |
| EP1556380B1 (fr) | 2006-04-12 |
| JP2006505577A (ja) | 2006-02-16 |
| DE60304596T2 (de) | 2007-05-10 |
| DK1556380T3 (da) | 2006-08-14 |
| WO2004037821A1 (fr) | 2004-05-06 |
| JP4599164B2 (ja) | 2010-12-15 |
| ATE323091T1 (de) | 2006-04-15 |
| FR2846330B1 (fr) | 2004-12-03 |
| AR041690A1 (es) | 2005-05-26 |
| PT1556380E (pt) | 2006-08-31 |
| EP1556380A1 (fr) | 2005-07-27 |
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