TR201910644T4 - CMV'ye yönelik bir aşı olarak koşullu bir replike edici sitomegalovirüs. - Google Patents
CMV'ye yönelik bir aşı olarak koşullu bir replike edici sitomegalovirüs. Download PDFInfo
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- TR201910644T4 TR201910644T4 TR2019/10644T TR201910644T TR201910644T4 TR 201910644 T4 TR201910644 T4 TR 201910644T4 TR 2019/10644 T TR2019/10644 T TR 2019/10644T TR 201910644 T TR201910644 T TR 201910644T TR 201910644 T4 TR201910644 T4 TR 201910644T4
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- cmv
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- replication
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- cytomegalvirus
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- 241000701022 Cytomegalovirus Species 0.000 title 1
- 230000003362 replicative effect Effects 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 230000010076 replication Effects 0.000 abstract 2
- 206010011831 Cytomegalovirus infection Diseases 0.000 abstract 1
- 206010042566 Superinfection Diseases 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007420 reactivation Effects 0.000 abstract 1
- 230000029812 viral genome replication Effects 0.000 abstract 1
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- C07K14/01—DNA viruses
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- C12N15/62—DNA sequences coding for fusion proteins
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- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Life Sciences & Earth Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract
Mevcut buluş, koşullu olarak replikasyon yeteneğinden yoksun olan genetiği değiştirilmiş bir sitomegalvirüs CMV kullanarak sitomegalvirüse (CMV) bir immün yanıt indükleme yöntemleri ile ilgilidir. Buluşun yöntemleri primer CMV enfeksiyonunu, bir latent CMV?nin yeniden aktif hale gelmesinden kaynaklanan enfeksiyonu ve daha önce karşılaşılmış olan CMV?nin farklı bir suşunun bir süperenfeksiyonunu tedavi etmek ve/veya önlemek amacı ile kullanılabilir. Mevcut buluş aynı zamanda, viral replikasyonun harici olarak kontrol edilmesine olanak verecek şekilde rekombinant olarak değiştirilmiş olan bir replikasyon yeteneğinden yoksun CMV ile de ilgilidir. Replikasyon yeteneğinden yoksun CMV içeren bileşimler de aynı zamanda mevcut buluşun kapsamı içerisindedir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161532667P | 2011-09-09 | 2011-09-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201910644T4 true TR201910644T4 (tr) | 2019-08-21 |
Family
ID=47832753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/10644T TR201910644T4 (tr) | 2011-09-09 | 2012-09-04 | CMV'ye yönelik bir aşı olarak koşullu bir replike edici sitomegalovirüs. |
Country Status (33)
Country | Link |
---|---|
US (1) | US9546355B2 (tr) |
EP (3) | EP3251700B1 (tr) |
JP (1) | JP5926804B2 (tr) |
KR (1) | KR101668163B1 (tr) |
CN (1) | CN103889462B (tr) |
AR (1) | AR087772A1 (tr) |
AU (1) | AU2012304783B2 (tr) |
BR (1) | BR112014005404A8 (tr) |
CA (1) | CA2846870C (tr) |
CL (1) | CL2014000541A1 (tr) |
CY (2) | CY1119107T1 (tr) |
DK (2) | DK2753364T3 (tr) |
ES (2) | ES2633190T3 (tr) |
HR (2) | HRP20171120T1 (tr) |
HU (2) | HUE035322T2 (tr) |
IL (1) | IL231272B (tr) |
IN (1) | IN2014CN01809A (tr) |
LT (2) | LT3251700T (tr) |
ME (2) | ME03488B (tr) |
MX (1) | MX353037B (tr) |
NZ (1) | NZ622156A (tr) |
PE (1) | PE20141525A1 (tr) |
PL (2) | PL3251700T3 (tr) |
PT (2) | PT3251700T (tr) |
RS (2) | RS58891B1 (tr) |
RU (2) | RU2670012C1 (tr) |
SG (1) | SG11201400419YA (tr) |
SI (2) | SI2753364T1 (tr) |
TR (1) | TR201910644T4 (tr) |
TW (1) | TWI570240B (tr) |
UA (1) | UA114896C2 (tr) |
WO (1) | WO2013036465A2 (tr) |
ZA (1) | ZA201401708B (tr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2016501023A (ja) * | 2012-12-04 | 2016-01-18 | メルク・シャープ・アンド・ドーム・コーポレーションM | 条件付き複製ウイルスベクター |
MX2015016978A (es) * | 2013-06-10 | 2016-04-25 | Merck Sharp & Dohme | Proteinas de union a antigeno neutralizantes de citomegalovirus. |
WO2016011293A1 (en) | 2014-07-16 | 2016-01-21 | Oregon Health & Science University | Human cytomegalovirus comprising exogenous antigens |
EP3048114A1 (en) * | 2015-01-22 | 2016-07-27 | Novartis AG | Cytomegalovirus antigens and uses thereof |
WO2017070613A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Human cytomegalovirus vaccine |
US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
WO2018075980A1 (en) | 2016-10-21 | 2018-04-26 | Modernatx, Inc. | Human cytomegalovirus vaccine |
BR112020008482A8 (pt) * | 2017-11-01 | 2023-01-31 | Merck Sharp & Dohme | Composto leuco |
US20210047626A1 (en) * | 2018-04-24 | 2021-02-18 | Merck Sharp & Dohme Corp. | Scalable chromatography process for purification of human cytomegalovirus |
US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
US20220090005A1 (en) | 2019-01-03 | 2022-03-24 | Merck Sharp & Dohme Corp. | Supplemented Serum-Containing Culture Medium for Enhanced Arpe-19 Growth and Human Cytomegalovirus Vaccine Production |
CA3146798A1 (en) * | 2019-07-12 | 2021-01-21 | Kobenhavns Universitet | Fusion toxin proteins for treatment of diseases related to cmv infections |
US11857622B2 (en) | 2020-06-21 | 2024-01-02 | Pfizer Inc. | Human cytomegalovirus GB polypeptide |
US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
CN112481222B (zh) * | 2020-11-30 | 2024-01-02 | 中国医学科学院医学生物学研究所 | 一种条件复制型重组单纯疱疹病毒、疫苗及其应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1150712T3 (da) * | 1999-02-05 | 2009-02-02 | Merck & Co Inc | Vaccineformuleringer mod human papillomavirus |
ES2429338T3 (es) | 2002-12-23 | 2013-11-14 | Vical Incorporated | Vacuna basada en polinucleótidos optimizados por codones contra infección por citomegalovirus humano |
US20060110406A1 (en) * | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
WO2004076645A2 (en) * | 2003-02-27 | 2004-09-10 | University Of Massachusetts | Compositions and methods for cytomegalovirus treatment |
NZ560929A (en) * | 2005-02-18 | 2009-12-24 | Novartis Vaccines & Diagnostic | Immunogens from uropathogenic escherichia coli |
EP2037959B1 (en) * | 2006-06-07 | 2016-01-27 | The Trustees Of Princeton University | Cytomegalovirus surface protein complex for use in vaccines and as a drug target |
US8173792B2 (en) * | 2007-02-09 | 2012-05-08 | The Board Of Trustees Of The Leland Stanford Junior University | Method for regulating protein function in cells using synthetic small molecules |
US9439960B2 (en) * | 2007-10-10 | 2016-09-13 | The Trustees Of Princeton University | Cytomegalovirus vaccines and methods of production |
US8530636B2 (en) * | 2008-05-07 | 2013-09-10 | The Board Of Trustees Of The Leland Stanford Junior University | Method for regulating protein function in cells in vivo using synthetic small molecules |
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