TR201910084T4 - Radyoaktif-etiketli prostat spesifik membran antijen inhibitörleri. - Google Patents
Radyoaktif-etiketli prostat spesifik membran antijen inhibitörleri. Download PDFInfo
- Publication number
- TR201910084T4 TR201910084T4 TR2019/10084T TR201910084T TR201910084T4 TR 201910084 T4 TR201910084 T4 TR 201910084T4 TR 2019/10084 T TR2019/10084 T TR 2019/10084T TR 201910084 T TR201910084 T TR 201910084T TR 201910084 T4 TR201910084 T4 TR 201910084T4
- Authority
- TR
- Turkey
- Prior art keywords
- formula
- radioactive
- prostate specific
- specific membrane
- membrane antigen
- Prior art date
Links
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 title abstract 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000002285 radioactive effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000000694 effects Effects 0.000 abstract 2
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
Abstract
Formül I'e ve Formül II'ye göre bileşikler PSMA aktivitesinin güçlü inhibitörleridir: Buluş ayrıca, bir radyonüklidin ve bir Formül I bileşiğinin veya bir Formül II bileşiğinin bir kompleksinin farmasötik bileşimlerini ve PSMA aktivitesi ile ilişkilendirilmiş bir hastalığı veya bir rahatsızlığı tedavi etme veya bunun tanısı için bir Formül I bileşiğinin veya bir Formül II bileşiğinin radyonüklid kompleksini kullanmanın yöntemlerini de sağlar.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161515674P | 2011-08-05 | 2011-08-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201910084T4 true TR201910084T4 (tr) | 2019-08-21 |
Family
ID=47627059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/10084T TR201910084T4 (tr) | 2011-08-05 | 2012-08-03 | Radyoaktif-etiketli prostat spesifik membran antijen inhibitörleri. |
Country Status (10)
Country | Link |
---|---|
US (2) | US8926944B2 (tr) |
EP (2) | EP3505192A1 (tr) |
JP (1) | JP5843338B2 (tr) |
AU (1) | AU2012294639B2 (tr) |
CA (1) | CA2844151C (tr) |
ES (1) | ES2732060T3 (tr) |
HU (1) | HUE045028T2 (tr) |
PL (1) | PL2739316T3 (tr) |
TR (1) | TR201910084T4 (tr) |
WO (1) | WO2013022797A1 (tr) |
Families Citing this family (63)
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CN101778910B (zh) | 2006-11-08 | 2014-05-28 | 分子制药洞察公司 | 谷氨酸的异质二聚体 |
NZ616957A (en) | 2007-02-19 | 2015-06-26 | Marinepolymer Tech Inc | Hemostatic compositions and therapeutic regimens |
JP2010536790A (ja) | 2007-08-17 | 2010-12-02 | パーデュー・リサーチ・ファウンデーション | Psma結合性リガンド−リンカー結合体及び使用方法 |
WO2010065899A2 (en) * | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof |
WO2017053268A1 (en) * | 2015-09-21 | 2017-03-30 | Serrano-Ojeda Pedro Anastacio | Glutamine-high z element compounds for treating cancer |
US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
WO2013028664A1 (en) * | 2011-08-22 | 2013-02-28 | Siemens Medical Solutions Usa, Inc. | Psma imaging agents |
WO2013103813A1 (en) | 2012-01-06 | 2013-07-11 | Molecular Insight Pharmaceuticals | Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase ix |
BR112015011118B1 (pt) | 2012-11-15 | 2022-12-13 | Endocyte, Inc | Conjugado; composição farmacêutica; e uso de um conjugado |
ES2738474T3 (es) | 2013-01-14 | 2020-01-23 | Molecular Insight Pharm Inc | Radiofármacos a base de triazina y agentes radioimagenológicos |
US10232058B2 (en) | 2013-10-14 | 2019-03-19 | The Johns Hopkins University | Prostate-specific membrane antigen-targeted photosensitizers for photodynamic therapy |
TN2016000137A1 (en) * | 2013-10-18 | 2017-10-06 | Deutsches Krebsforsch | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer. |
EP2862857A1 (en) | 2013-10-18 | 2015-04-22 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
EA035171B1 (ru) * | 2013-11-14 | 2020-05-08 | Эндосайт, Инк. | Конъюгаты на основе связывающихся с psma лигандов или ингибиторов psma для позитронно-эмиссионной томографии |
US20160303258A1 (en) * | 2013-12-03 | 2016-10-20 | Millennium Pharmaceuticals, Inc. | Compounds and compositions for imaging gcc-expressing cells |
EP3536345A1 (en) * | 2014-05-06 | 2019-09-11 | The Johns Hopkins University | Metal/radiometal-labeled psma inhibitors for psma-targeted imaging and radiotherapy |
CA2959726A1 (en) * | 2014-09-08 | 2016-03-17 | Molecular Insight Pharmaceuticals, Inc. | Organ protection in psma-targeted radionuclide therapy of prostate cancer |
EP3011976A1 (en) | 2014-10-20 | 2016-04-27 | Deutsches Krebsforschungszentrum | 18F-tagged inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents |
WO2016062370A1 (en) | 2014-10-20 | 2016-04-28 | Deutsches Krebsforschungszentrum | 18f-tagged inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
US10736974B2 (en) | 2014-10-22 | 2020-08-11 | The Johns Hopkins University | Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy |
US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
US10869940B2 (en) | 2015-06-12 | 2020-12-22 | The Board Of Trustees Of The Leland Stanford Junior University | Targeted photoacoustic compounds, formulations, and uses thereof |
HUE053064T2 (hu) | 2015-09-30 | 2021-06-28 | Deutsches Krebsforsch | Prosztataspecifikus membránantigén (PSMA) 18F-címkézett inhibitorai és azok alkalmazása képalkotó ágensként prosztatarákkal |
KR101639599B1 (ko) * | 2015-11-09 | 2016-07-14 | 서울대학교산학협력단 | 펩타이드 싸이오우레아 유도체, 이를 포함하는 방사성 동위원소 표지 화합물 및 이를 유효 성분으로 함유하는 전립선암 치료 또는 진단용 약학적 조성물 |
US10688200B2 (en) * | 2015-12-31 | 2020-06-23 | Five Eleven Pharma Inc. | Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy |
TR201813644T1 (tr) | 2016-03-22 | 2018-11-21 | Univ Johns Hopkins | Prostat kanserinin endoradyoterapisi için prostat-spesifik membran antijen hedefli yüksek afiniteli ajanlar. |
FI127538B (en) * | 2016-06-22 | 2018-08-31 | Dextech Medical Ab | MODIFIED Dextran Conjugates |
WO2018098390A1 (en) * | 2016-11-23 | 2018-05-31 | Cancer Targeted Technology Llc | Albumin-binding psma inhibitors |
JP7034160B2 (ja) | 2016-11-28 | 2022-03-11 | バイエル・ファルマ・アクティエンゲゼルシャフト | 磁気共鳴画像法に使用するための高緩和度ガドリニウムキレート化合物 |
DE212016000299U1 (de) * | 2016-12-15 | 2019-09-05 | The European Atomic Energy Community (Euratom), Represented By The European Commission | Behandlung vpm PMSA-exprimierenden Krebsarten |
JP7396897B2 (ja) * | 2017-04-05 | 2023-12-12 | コーネル ユニバーシティー | 画像化および抗腫瘍治療において有用な調整可能な薬物動態を有する三官能性構築物 |
WO2018204477A1 (en) | 2017-05-02 | 2018-11-08 | Cornell University | Methods and reagents for tumor targeting with greater efficacy and less toxicity |
US11629201B2 (en) | 2017-05-24 | 2023-04-18 | ITM Isotope Technologies Munich SE | PSMA-binding agents and uses thereof |
WO2018233798A1 (en) | 2017-06-20 | 2018-12-27 | ITM Isotopen Technologien München AG | NOVEL PSMA BINDING AGENTS AND USE THEREOF |
CN111032632B (zh) * | 2017-05-30 | 2024-04-12 | 约翰霍普金斯大学 | 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂 |
MX2019015616A (es) * | 2017-06-19 | 2020-02-26 | Futurechem Co Ltd | Compuesto marcado con 18f para diagnostico de cancer de prostata y uso de este. |
WO2018236115A1 (ko) * | 2017-06-19 | 2018-12-27 | (주)퓨쳐켐 | 전립선암 진단을 위한 18f-표지된 화합물 및 그의 용도 |
WO2019115684A1 (en) * | 2017-12-13 | 2019-06-20 | Sciencons AS | Complex comprising a psma-targeting compound linked to a lead or thorium radionuclide |
MX2020008247A (es) * | 2018-02-06 | 2021-02-26 | Univ Johns Hopkins | Urea-poliaminocarboxilatos radiohalogenados dirigidos a antígeno prostático específico de membrana (psma) para radioterapia de cáncer. |
MX2020010266A (es) * | 2018-03-30 | 2020-11-06 | Futurechem Co Ltd | Radiofarmaco dirigido a antigeno de membrana especifico de prostata (psma) para diagnosticar y tratar el cancer de prostata. |
EP3590911A1 (en) * | 2018-07-01 | 2020-01-08 | Studiengesellschaft Kohle MbH | Reagent and process for the site-specific deoxyfluorination of peptides |
EP3856261A1 (en) | 2018-09-28 | 2021-08-04 | Universität Heidelberg | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of psma-expressing cancers |
US11944690B2 (en) | 2018-11-23 | 2024-04-02 | Bayer Aktiengesellschaft | Formulation of contrast media and process of preparation thereof |
WO2020108753A1 (en) | 2018-11-28 | 2020-06-04 | ITM Isotopen Technologien München AG | Novel tumor antigen binding agents and uses thereof |
CN113710286A (zh) * | 2019-02-14 | 2021-11-26 | 海德堡鲁普雷希特卡尔斯大学 | 具有改善的组织特异性的前列腺特异性膜抗原(psma)配体 |
JP2022520798A (ja) | 2019-02-14 | 2022-04-01 | ドイチェス クレブスフォルシュンクスツェントルム | アミラーゼ切断可能なリンカーを含む前立腺特異的膜抗原(psma)リガンド |
WO2020220023A1 (en) * | 2019-04-26 | 2020-10-29 | Five Eleven Pharma Inc. | Prostate-specific membrane antigen (psma) inhibitors as diagnostic and radionuclide therapeutic agents |
US20230072421A1 (en) | 2019-07-25 | 2023-03-09 | Bayer As | Targeted radiopharmaceuticals for the diagnosis and treatment of prostate cancer |
EP4041213A4 (en) * | 2019-10-29 | 2023-12-27 | The Cleveland Clinic Foundation | CONTRAST AGENTS DIRECTED AGAINST PSMA |
WO2022096103A1 (en) | 2020-11-05 | 2022-05-12 | ITM Isotopen Technologien München AG | Combination of para-aminohippuric acid (pah) and radiolabeled complexes for treating cancer |
US20230406847A1 (en) | 2020-11-12 | 2023-12-21 | Abx Advanced Biochemical Compounds Gmbh | Ligands of prostate specific membrane antigen (psma) containing heteroaromatic linker building blocks |
WO2022111800A1 (en) | 2020-11-25 | 2022-06-02 | Itm Solucin Gmbh | Stable formulations for radionuclide complexes |
JP2024503908A (ja) | 2021-01-22 | 2024-01-29 | バイエル アクチェンゲゼルシャフト | Lrrc15抗体およびそのコンジュゲート |
AU2022293573A1 (en) * | 2021-06-17 | 2023-12-14 | Mayo Foundation For Medical Education And Research | Methods and materials for combining biologics with multiple chelators |
CN115745903A (zh) * | 2021-09-03 | 2023-03-07 | 晶核生物医药科技(南京)有限公司 | 一种肽脲素衍生物、含其的药物组合物及其应用 |
WO2023086833A1 (en) * | 2021-11-09 | 2023-05-19 | Case Western Reserve University | Psma targeted conjugate compounds and uses thereof |
WO2023208928A1 (en) | 2022-04-26 | 2023-11-02 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Dosage of psma-ligands for fluorescence based detection of cancerous tissue |
WO2023222680A1 (en) | 2022-05-17 | 2023-11-23 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Prostate specific membrane antigen (psma) ligands |
WO2023222681A1 (en) | 2022-05-17 | 2023-11-23 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Prostate specific membrane antigen (psma) ligands with improved renal clearance |
WO2023222682A1 (en) | 2022-05-17 | 2023-11-23 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Prostate specific membrane antigen (psma) ligands |
WO2023222679A1 (en) | 2022-05-17 | 2023-11-23 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Prostate specific membrane antigen (psma) ligands |
WO2023231452A1 (zh) * | 2023-02-14 | 2023-12-07 | 北京师范大学 | 含硝基芳香杂环基团的psma靶向放射性金属配合物及其制备 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7408079B2 (en) * | 2002-01-10 | 2008-08-05 | The Johns Hopkins University | Imaging agents and methods of imaging NAALADase or PSMA |
CN101778910B (zh) * | 2006-11-08 | 2014-05-28 | 分子制药洞察公司 | 谷氨酸的异质二聚体 |
EP2921482B1 (en) * | 2007-06-26 | 2018-09-05 | The Johns Hopkins University | Labeled inhibitors of prostate-specific membrane antigen (psma), biological evaluation, and use as imaging agents |
CA2745955C (en) * | 2008-12-05 | 2017-05-23 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium- bis (heteroaryl) complexes and methods of use thereof for inhibiting psma |
HUE059796T2 (hu) | 2009-03-19 | 2022-12-28 | Univ Johns Hopkins | PSMA-t célzó vegyületek és alkalmazásaik |
-
2012
- 2012-08-03 CA CA2844151A patent/CA2844151C/en active Active
- 2012-08-03 PL PL12822647T patent/PL2739316T3/pl unknown
- 2012-08-03 AU AU2012294639A patent/AU2012294639B2/en active Active
- 2012-08-03 WO PCT/US2012/049644 patent/WO2013022797A1/en unknown
- 2012-08-03 US US13/566,849 patent/US8926944B2/en active Active
- 2012-08-03 TR TR2019/10084T patent/TR201910084T4/tr unknown
- 2012-08-03 JP JP2014524142A patent/JP5843338B2/ja active Active
- 2012-08-03 HU HUE12822647A patent/HUE045028T2/hu unknown
- 2012-08-03 EP EP19155531.7A patent/EP3505192A1/en active Pending
- 2012-08-03 ES ES12822647T patent/ES2732060T3/es active Active
- 2012-08-03 EP EP12822647.9A patent/EP2739316B1/en active Active
-
2014
- 2014-11-25 US US14/553,157 patent/US9388144B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2739316A4 (en) | 2015-03-11 |
US9388144B2 (en) | 2016-07-12 |
AU2012294639A1 (en) | 2014-02-27 |
CA2844151C (en) | 2022-11-29 |
HUE045028T2 (hu) | 2019-12-30 |
AU2012294639B2 (en) | 2017-10-26 |
US20150078998A1 (en) | 2015-03-19 |
US20130034494A1 (en) | 2013-02-07 |
JP2014524419A (ja) | 2014-09-22 |
ES2732060T3 (es) | 2019-11-20 |
AU2012294639A8 (en) | 2014-03-06 |
WO2013022797A1 (en) | 2013-02-14 |
EP3505192A1 (en) | 2019-07-03 |
EP2739316B1 (en) | 2019-04-10 |
EP2739316A1 (en) | 2014-06-11 |
JP5843338B2 (ja) | 2016-01-13 |
US8926944B2 (en) | 2015-01-06 |
PL2739316T3 (pl) | 2019-09-30 |
CA2844151A1 (en) | 2013-02-14 |
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