TR201909574T4 - METHOD FOR PRODUCING HYDROXYETHYL STARCH DERIVATIVES. - Google Patents
METHOD FOR PRODUCING HYDROXYETHYL STARCH DERIVATIVES. Download PDFInfo
- Publication number
- TR201909574T4 TR201909574T4 TR2019/09574T TR201909574T TR201909574T4 TR 201909574 T4 TR201909574 T4 TR 201909574T4 TR 2019/09574 T TR2019/09574 T TR 2019/09574T TR 201909574 T TR201909574 T TR 201909574T TR 201909574 T4 TR201909574 T4 TR 201909574T4
- Authority
- TR
- Turkey
- Prior art keywords
- temperature
- value
- solution
- adjusting
- hydroxyethyl starch
- Prior art date
Links
- 229920001612 Hydroxyethyl starch Polymers 0.000 title claims abstract 9
- 229940050526 hydroxyethylstarch Drugs 0.000 title claims abstract 9
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- 229920002472 Starch Polymers 0.000 claims abstract 3
- 235000019698 starch Nutrition 0.000 claims abstract 3
- 239000008107 starch Substances 0.000 claims abstract 3
- KWMLJOLKUYYJFJ-UHFFFAOYSA-N 2,3,4,5,6,7-Hexahydroxyheptanoic acid Chemical group OCC(O)C(O)C(O)C(O)C(O)C(O)=O KWMLJOLKUYYJFJ-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 10
- 238000010438 heat treatment Methods 0.000 claims 8
- 238000001816 cooling Methods 0.000 claims 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 150000002505 iron Chemical class 0.000 claims 2
- 150000002506 iron compounds Chemical class 0.000 claims 2
- 238000001542 size-exclusion chromatography Methods 0.000 claims 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical group [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 1
- -1 cyanide compound Chemical class 0.000 claims 1
- 238000001825 field-flow fractionation Methods 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 229920001592 potato starch Polymers 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C08B31/10—Alkyl or cycloalkyl ethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/18—Oxidised starch
- C08B31/185—Derivatives of oxidised starch, e.g. crosslinked oxidised starch
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11170761A EP2537866A1 (en) | 2011-06-21 | 2011-06-21 | Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201909574T4 true TR201909574T4 (en) | 2019-08-21 |
Family
ID=44799422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/09574T TR201909574T4 (en) | 2011-06-21 | 2012-06-21 | METHOD FOR PRODUCING HYDROXYETHYL STARCH DERIVATIVES. |
Country Status (22)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6616725B2 (ja) * | 2016-03-31 | 2019-12-04 | 日本製紙株式会社 | 塗工紙用澱粉 |
| WO2020144667A1 (en) | 2019-01-10 | 2020-07-16 | Pharmacosmos Holding A/S | Treating iron deficiency in subjects at risk of cardiovascular adverse events and iron for the management of atrial fibrillation |
| CN114286682A (zh) | 2019-02-09 | 2022-04-05 | 法码科思莫斯控股有限公司 | 治疗具有心血管不良事件风险的个体的铁缺乏以及用于治疗心房颤动的铁 |
| KR20240041957A (ko) | 2021-08-03 | 2024-04-01 | 파르마코스모스 홀딩 에이/에스 | 반려동물의 철 결핍증 치료방법에서 피하 사용을 위한 철 착화합물 |
| CN117547549A (zh) * | 2023-11-09 | 2024-02-13 | 黑龙江八一农垦大学 | 适用于犬arf的腹膜透析液与助清除剂的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3639588A (en) * | 1966-10-22 | 1972-02-01 | Fisons Pharmaceuticals Ltd | Pharmaceutical compositions containing ferric hydroxide complexed with dextran or dextrin heptonic acids |
| US4370476A (en) * | 1979-07-17 | 1983-01-25 | Usher Thomas C | Dextran polycarboxylic acids, ferric hydroxide complexes |
| GB8902894D0 (en) * | 1989-02-09 | 1989-03-30 | Fisons Plc | Compositions |
| JPH0566372A (ja) * | 1991-09-10 | 1993-03-19 | Fukui Megane Kogyo Kk | 金属製眼鏡フレーム部品の製造方法 |
| JPH0776524A (ja) * | 1993-07-13 | 1995-03-20 | Takeda Chem Ind Ltd | 動物用抗貧血剤 |
| DK172860B1 (da) * | 1998-03-25 | 1999-08-16 | Pharmacosmos Holding As | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
| DK173138B1 (da) * | 1998-11-20 | 2000-02-07 | Pharmacosmos Holding As | Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma |
| EP1762250A1 (en) * | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine |
| EP2176215B1 (en) * | 2007-08-17 | 2014-10-08 | Akzo Nobel N.V. | Glutamic acid n,n-diacetic amide, glutamic acid n-acetic amide n-acetonitrile, alkali metal salts thereof, process to prepare them and their use |
| TWI469965B (zh) * | 2008-12-22 | 2015-01-21 | Ono Pharmaceutical Co | 乙炔基吲哚化合物 |
| JP5397991B2 (ja) * | 2009-04-01 | 2014-01-22 | 学校法人東京農業大学 | 乳酸菌を用いたビタミンｂ１２の定量方法 |
-
2011
- 2011-06-21 EP EP11170761A patent/EP2537866A1/en not_active Withdrawn
-
2012
- 2012-06-21 HR HRP20191173TT patent/HRP20191173T1/hr unknown
- 2012-06-21 US US14/127,766 patent/US9181353B2/en active Active
- 2012-06-21 RS RS20190850A patent/RS59021B1/sr unknown
- 2012-06-21 EP EP12737229.0A patent/EP2723774B1/en active Active
- 2012-06-21 JP JP2014516345A patent/JP6370217B2/ja active Active
- 2012-06-21 MX MX2013015075A patent/MX337682B/es active IP Right Grant
- 2012-06-21 CN CN201280029882.3A patent/CN103649128B/zh active Active
- 2012-06-21 SM SM20190430T patent/SMT201900430T1/it unknown
- 2012-06-21 ES ES12737229T patent/ES2733767T3/es active Active
- 2012-06-21 SI SI201231627T patent/SI2723774T1/sl unknown
- 2012-06-21 PT PT12737229T patent/PT2723774T/pt unknown
- 2012-06-21 CA CA2837784A patent/CA2837784C/en active Active
- 2012-06-21 PL PL12737229T patent/PL2723774T3/pl unknown
- 2012-06-21 TR TR2019/09574T patent/TR201909574T4/en unknown
- 2012-06-21 CN CN201510909616.5A patent/CN105348401A/zh active Pending
- 2012-06-21 WO PCT/EP2012/061958 patent/WO2012175608A1/en not_active Ceased
- 2012-06-21 BR BR112013032901A patent/BR112013032901A2/pt not_active Application Discontinuation
- 2012-06-21 LT LTEP12737229.0T patent/LT2723774T/lt unknown
- 2012-06-21 DK DK12737229.0T patent/DK2723774T3/da active
- 2012-06-21 HU HUE12737229 patent/HUE044428T2/hu unknown
- 2012-06-21 TW TW101122208A patent/TWI564010B/zh active
-
2015
- 2015-10-26 US US14/922,897 patent/US9631032B2/en active Active
-
2016
- 2016-07-12 HK HK16108112.8A patent/HK1220218A1/zh unknown
-
2018
- 2018-03-27 JP JP2018059264A patent/JP2018100424A/ja active Pending
-
2019
- 2019-07-03 CY CY20191100704T patent/CY1121976T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2013015075A (es) | 2014-04-14 |
| US20160046733A1 (en) | 2016-02-18 |
| MX337682B (es) | 2016-03-15 |
| RS59021B1 (sr) | 2019-08-30 |
| HK1220218A1 (zh) | 2017-04-28 |
| CA2837784C (en) | 2019-10-15 |
| ES2733767T3 (es) | 2019-12-02 |
| WO2012175608A1 (en) | 2012-12-27 |
| PL2723774T3 (pl) | 2019-10-31 |
| DK2723774T3 (da) | 2019-07-15 |
| CA2837784A1 (en) | 2012-12-27 |
| TWI564010B (zh) | 2017-01-01 |
| JP2014520188A (ja) | 2014-08-21 |
| BR112013032901A2 (pt) | 2017-01-24 |
| US9181353B2 (en) | 2015-11-10 |
| HRP20191173T1 (hr) | 2019-10-04 |
| EP2723774A1 (en) | 2014-04-30 |
| SI2723774T1 (sl) | 2019-08-30 |
| SMT201900430T1 (it) | 2019-09-09 |
| HUE044428T2 (hu) | 2019-10-28 |
| EP2723774B1 (en) | 2019-04-03 |
| CY1121976T1 (el) | 2020-10-14 |
| US9631032B2 (en) | 2017-04-25 |
| EP2537866A1 (en) | 2012-12-26 |
| CN103649128A (zh) | 2014-03-19 |
| CN105348401A (zh) | 2016-02-24 |
| JP6370217B2 (ja) | 2018-08-08 |
| TW201315474A (zh) | 2013-04-16 |
| PT2723774T (pt) | 2019-07-15 |
| CN103649128B (zh) | 2016-02-10 |
| JP2018100424A (ja) | 2018-06-28 |
| LT2723774T (lt) | 2019-08-12 |
| US20140128594A1 (en) | 2014-05-08 |
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