TR201903815T4 - Nanoyapılar ve bunların uygulamaları. - Google Patents

Nanoyapılar ve bunların uygulamaları. Download PDF

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Publication number
TR201903815T4
TR201903815T4 TR2019/03815T TR201903815T TR201903815T4 TR 201903815 T4 TR201903815 T4 TR 201903815T4 TR 2019/03815 T TR2019/03815 T TR 2019/03815T TR 201903815 T TR201903815 T TR 201903815T TR 201903815 T4 TR201903815 T4 TR 201903815T4
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TR
Turkey
Prior art keywords
compositions
monomer residues
polymeric framework
middle portion
crosslinked
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TR2019/03815T
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English (en)
Inventor
Axelsson Oskar
Bäckström Sania
Petoral Rodrigo Jr
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Spago Nanomedical Ab
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Publication date
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Publication of TR201903815T4 publication Critical patent/TR201903815T4/tr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A61K51/1251—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles micro- or nanospheres, micro- or nanobeads, micro- or nanocapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/30—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen phosphorus-containing groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Burada 8-100 nm'lik bir hidrodinamik çapa (Dh) sahip olan, bir orta kısım ve bir çevresel kısım içeren bir globüler nanoyapı açıklanmakta olup, burada; söz konusu orta kısım 6-90 nm'lik bir hesaplanmış çapa (Dc) sahiptir ve söz konusu çevresel kısım Dh=Dc+2Tp olacak şekilde tahmini bir kalınlığa (Tp) sahip olması, burada söz konusu orta kısım aşağıdaki unsurları içermektedir: (i) monomer kalıntıları içeren bir çapraz bağlı polimerik çerçeve, burada monomer kalıntılarının sayıca en az %30'u çapraz bağlanmaktadır böylelikle çapraz bağlı polimerik çerçeve oluşturmaktadır ve/veya (ii) monomer kalıntıları içeren bir dallanmış polimerik çerçeve, burada dal noktalarının sayısı monomer kalıntılarının en az %30'udur, burada söz konusu orta kısım en az 4'ü çok yüklü en az bir katyonun şelasyonuna olanak sağlayan şelatlayıcı gruplar içermektedir, burada söz konusu şelatlayıcı gruplar -COOR1, -P=O(OR1)(OR2) ve -S(=O)2OR1'den oluşan gruptan bağımsız olarak seçilmektedir, burada R1 ve R2, bir negatif yük, H, düşük alkiller ve arilden oluşan gruptan bağımsız olarak seçilmektedir ve burada söz konusu çevresel kısım orta kısma kovalent olarak eklenen bir sentetik polimer malzeme içermektedir, burada sentetik polimer malzeme hidrofilik ve biyoinerttür ve elektriksel olarak nötr veya zwitteriyoniktir. Ayrıca bu nanoparçacıkları ve opsiyonel olarak bir radyonüklidi içeren bileşimler, bu bileşimlerin kullanımı, bu bileşimleri içeren kitler ve bu bileşimleri elde etmeye yönelik yöntemler açıklanmaktadır.
TR2019/03815T 2014-03-28 2015-03-27 Nanoyapılar ve bunların uygulamaları. TR201903815T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14162399.1A EP2923712A1 (en) 2014-03-28 2014-03-28 Nanostructures and applications thereof

Publications (1)

Publication Number Publication Date
TR201903815T4 true TR201903815T4 (tr) 2019-04-22

Family

ID=50478704

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/03815T TR201903815T4 (tr) 2014-03-28 2015-03-27 Nanoyapılar ve bunların uygulamaları.

Country Status (14)

Country Link
US (1) US9999693B2 (tr)
EP (2) EP2923712A1 (tr)
JP (1) JP6707074B2 (tr)
KR (1) KR102347377B1 (tr)
CN (1) CN106232146B (tr)
AU (1) AU2015238208B2 (tr)
CA (1) CA2943852C (tr)
DK (1) DK3122383T3 (tr)
ES (1) ES2715885T3 (tr)
IL (1) IL248014B (tr)
PL (1) PL3122383T3 (tr)
RU (1) RU2684777C2 (tr)
TR (1) TR201903815T4 (tr)
WO (1) WO2015144891A1 (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3348560A1 (en) 2017-01-16 2018-07-18 Spago Nanomedical AB Chemical compounds for coating of nanostructures
CN112316151B (zh) * 2020-10-30 2023-01-13 天津大学 一种基于共价三嗪环骨架化合物的纳米载体及其制备方法
EP4241793A1 (en) 2022-03-08 2023-09-13 Spago Nanomedical AB Globular nanostructures
EP4242250A1 (en) * 2022-03-08 2023-09-13 Spago Nanomedical AB Compounds for coating of nanostructures
EP4241765A1 (en) 2022-03-08 2023-09-13 Spago Nanomedical AB Globular nanostructures having an anchoring layer
EP4241792A1 (en) 2022-03-08 2023-09-13 Spago Nanomedical AB Nanostructures and applications thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803106B2 (en) 2002-04-16 2004-10-12 William Henry Campbell Multi-layered macromolecules and methods for their use
JP2004067703A (ja) 2002-04-24 2004-03-04 Japan Science & Technology Corp 架橋ポリマー、微粒子および製造方法
AU2003285905A1 (en) 2002-11-04 2004-06-07 Biosphere Medical, Inc. Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same
US20040258614A1 (en) 2003-06-20 2004-12-23 University Of Maryland, Baltimore Microparticles for microarterial imaging and radiotherapy
US20080095699A1 (en) * 2006-10-20 2008-04-24 Shiying Zheng Imaging contrast agents using nanoparticles
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
CN101663050A (zh) * 2007-02-07 2010-03-03 斯帕果图像有限公司 通过使用涂敷的造影剂的生物材料显像
US9468607B2 (en) * 2007-10-09 2016-10-18 Washington University Ligand directed toroidal nanoparticles for therapy and diagnostic imaging
WO2009110939A2 (en) * 2007-12-10 2009-09-11 Massachusetts Institute Of Technology Drug delivery system for pharmaceuticals and radiation
WO2009110936A2 (en) 2007-12-28 2009-09-11 Spring Bioscience Corporation Antigen retrieval methods for immunohistochemistry
IE20080211A1 (en) 2008-03-20 2009-11-25 Nat Univ Ireland Biodegradable nanoshells for delivery of therapeutic and/or imaging molecules
WO2009124388A1 (en) 2008-04-09 2009-10-15 Mcmaster University Hydrogel with covalently crosslinked core
EP2210616A1 (en) * 2009-01-21 2010-07-28 Centre National de la Recherche Scientifique Multifunctional stealth nanoparticles for biomedical use
US8470891B2 (en) 2009-12-23 2013-06-25 International Business Machines Corporation Biodegradable block polymers for drug delivery, and methods related thereto
EP2572736A1 (en) 2011-09-23 2013-03-27 Spago Imaging AB Nanostructures comprising manganese
US9415123B2 (en) * 2011-10-10 2016-08-16 The Regents Of The University Of Michigan Polymeric nanoparticles for ultrasound imaging and therapy
US9555132B2 (en) 2012-06-20 2017-01-31 The Trustees Of The University Of Pennsylvania Water-soluble nanoparticles

Also Published As

Publication number Publication date
JP2017509708A (ja) 2017-04-06
DK3122383T3 (en) 2019-04-08
KR20160137634A (ko) 2016-11-30
WO2015144891A1 (en) 2015-10-01
RU2684777C2 (ru) 2019-04-15
US20170106105A1 (en) 2017-04-20
ES2715885T3 (es) 2019-06-06
CN106232146A (zh) 2016-12-14
RU2016140159A (ru) 2018-04-28
EP3122383B1 (en) 2018-12-26
AU2015238208A1 (en) 2016-09-29
PL3122383T3 (pl) 2019-08-30
KR102347377B1 (ko) 2022-01-07
EP3122383B8 (en) 2019-03-13
CA2943852C (en) 2022-07-19
JP6707074B2 (ja) 2020-06-10
EP3122383A1 (en) 2017-02-01
CN106232146B (zh) 2019-07-30
BR112016022054A2 (pt) 2017-08-15
EP2923712A1 (en) 2015-09-30
CA2943852A1 (en) 2015-10-01
RU2016140159A3 (tr) 2018-10-08
US9999693B2 (en) 2018-06-19
AU2015238208B2 (en) 2019-11-07
IL248014B (en) 2018-07-31

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