WO2018050942A8 - Nanopartículas con interiores protegidos, y métodos de uso de las mismas - Google Patents
Nanopartículas con interiores protegidos, y métodos de uso de las mismas Download PDFInfo
- Publication number
- WO2018050942A8 WO2018050942A8 PCT/ES2017/070617 ES2017070617W WO2018050942A8 WO 2018050942 A8 WO2018050942 A8 WO 2018050942A8 ES 2017070617 W ES2017070617 W ES 2017070617W WO 2018050942 A8 WO2018050942 A8 WO 2018050942A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nanoparticles
- methods
- same
- therapeutic molecules
- peptide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Nanopartículas con interiores protegidos, y métodos de uso de las mismas. La presente invención se refiere en general a partículas, incluyendo nanopartículas, por ejemplo, para la administración de fármacos u otras aplicaciones. Ciertos aspectos de la presente invención se dirigen generalmente a partículas, tales como nanopartículas, que comprende una parte interior y un recubrimiento. La parte interior puede contener insulina u otras moléculas terapéuticas para la administración a un ser vivo. En algunos casos, las moléculas pueden estar electrostáticamente complejadas con un péptido de carga opuesta, tal como un oligoarginina, u otras especies. Las especies típicamente están cargadas positivamente, por ejemplo, para moléculas terapéuticas ionizados negativamente a pH neutro. Las moléculas terapéuticas pueden ser también soluble en agua. En algunos casos, el péptido puede conjugarse con una porción hidrófoba, tales como colesterol, ácido láurico, o una cadena de ácido graso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201631221A ES2664584B2 (es) | 2016-09-19 | 2016-09-19 | Nanoparticulas con interiores protegidos, y métodos de uso de las mismas |
ESP201631221 | 2016-09-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2018050942A1 WO2018050942A1 (es) | 2018-03-22 |
WO2018050942A8 true WO2018050942A8 (es) | 2018-05-11 |
Family
ID=61617373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2017/070617 WO2018050942A1 (es) | 2016-09-19 | 2017-09-18 | Nanopartículas con interiores protegidos, y métodos de uso de las mismas |
Country Status (3)
Country | Link |
---|---|
US (1) | US10471020B2 (es) |
ES (1) | ES2664584B2 (es) |
WO (1) | WO2018050942A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2664584B2 (es) | 2016-09-19 | 2018-12-13 | Universidade De Santiago De Compostela | Nanoparticulas con interiores protegidos, y métodos de uso de las mismas |
CN109260174B (zh) * | 2018-09-04 | 2021-10-15 | 中山大学 | 一种治疗性蛋白纳米颗粒的高通量制备方法 |
JP2022540665A (ja) * | 2019-07-12 | 2022-09-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 機能化されたナノ粒子および細菌感染症の治療におけるその使用 |
CN113075342B (zh) * | 2020-01-04 | 2024-02-27 | 东莞市东阳光仿制药研发有限公司 | 一种分离检测德谷胰岛素侧链有关物质的方法 |
CN114617974B (zh) * | 2020-12-10 | 2023-10-03 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种多肽白蛋白纳米粒及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005032593A1 (ja) | 2003-10-01 | 2005-04-14 | Japan Science And Technology Agency | 核移行能を有するポリアルギニン修飾リポソーム |
US8709472B1 (en) | 2007-11-13 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Bioactive agent-loaded heart-targeting nanoparticles |
US9566349B2 (en) | 2010-10-14 | 2017-02-14 | Rutgers, The State University Of New Jersey | Intestinal peptide targeting ligands |
ES2385995B2 (es) | 2011-01-10 | 2013-05-21 | Universidade De Santiago De Compostela | Nanocápsulas con cubierta polimérica |
EP2886128A1 (en) | 2013-12-20 | 2015-06-24 | Nanobiotix | Pharmaceutical composition comprising nanoparticles, preparation and uses thereof |
CN104434806B (zh) | 2014-11-06 | 2017-05-03 | 中国人民解放军第四军医大学 | 一种具有高载药量及主动靶向效应的脂质混合plga纳米粒 |
CN104497147B (zh) | 2014-12-23 | 2018-07-03 | 四川大学 | 一种双受体识别的串联型穿膜肽修饰的肿瘤靶向纳米递药系统 |
ES2664584B2 (es) | 2016-09-19 | 2018-12-13 | Universidade De Santiago De Compostela | Nanoparticulas con interiores protegidos, y métodos de uso de las mismas |
-
2016
- 2016-09-19 ES ES201631221A patent/ES2664584B2/es active Active
- 2016-11-14 US US15/350,653 patent/US10471020B2/en active Active
-
2017
- 2017-09-18 WO PCT/ES2017/070617 patent/WO2018050942A1/es active Application Filing
Also Published As
Publication number | Publication date |
---|---|
ES2664584B2 (es) | 2018-12-13 |
ES2664584A1 (es) | 2018-04-20 |
US10471020B2 (en) | 2019-11-12 |
US20180078510A1 (en) | 2018-03-22 |
WO2018050942A1 (es) | 2018-03-22 |
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