TR201820474T4 - Spesifik immün modülatör profilleri indükleyen tanımlı nükleotitler arası bağlar bağlamında rna sekansı motifleri. - Google Patents

Spesifik immün modülatör profilleri indükleyen tanımlı nükleotitler arası bağlar bağlamında rna sekansı motifleri.

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Publication number
TR201820474T4
TR201820474T4 TR2018/20474T TR201820474T TR201820474T4 TR 201820474 T4 TR201820474 T4 TR 201820474T4 TR 2018/20474 T TR2018/20474 T TR 2018/20474T TR 201820474 T TR201820474 T TR 201820474T TR 201820474 T4 TR201820474 T4 TR 201820474T4
Authority
TR
Turkey
Prior art keywords
context
rna sequence
specific immune
internucleotide linkages
sequence motifs
Prior art date
Application number
TR2018/20474T
Other languages
English (en)
Turkish (tr)
Inventor
Jurk Marion
Jorg Vollmer Heinz
Original Assignee
Zoetis Belgium S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40351228&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201820474(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zoetis Belgium S A filed Critical Zoetis Belgium S A
Publication of TR201820474T4 publication Critical patent/TR201820474T4/tr

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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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TR2018/20474T 2007-08-13 2008-08-08 Spesifik immün modülatör profilleri indükleyen tanımlı nükleotitler arası bağlar bağlamında rna sekansı motifleri. TR201820474T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96444807P 2007-08-13 2007-08-13

Publications (1)

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TR201820474T4 true TR201820474T4 (tr) 2019-01-21

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ID=40351228

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TR2018/20474T TR201820474T4 (tr) 2007-08-13 2008-08-08 Spesifik immün modülatör profilleri indükleyen tanımlı nükleotitler arası bağlar bağlamında rna sekansı motifleri.

Country Status (22)

Country Link
US (3) US8128944B2 (enExample)
EP (1) EP2179039B1 (enExample)
JP (1) JP4847609B2 (enExample)
KR (1) KR20100045508A (enExample)
CN (1) CN101821392B (enExample)
AR (1) AR067928A1 (enExample)
AU (1) AU2008288241B2 (enExample)
BR (1) BRPI0814260B8 (enExample)
CA (1) CA2696630C (enExample)
CL (1) CL2008002371A1 (enExample)
CO (1) CO6260153A2 (enExample)
DK (1) DK2179039T3 (enExample)
ES (1) ES2703876T3 (enExample)
MX (1) MX2010001014A (enExample)
NZ (1) NZ582972A (enExample)
PL (1) PL2179039T3 (enExample)
PT (1) PT2179039T (enExample)
RU (1) RU2435851C2 (enExample)
SI (1) SI2179039T1 (enExample)
TR (1) TR201820474T4 (enExample)
TW (1) TW200916106A (enExample)
WO (1) WO2009022216A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4847609B2 (ja) 2007-08-13 2011-12-28 コーリー ファーマシューティカル ゲーエムベーハー 特異的な免疫修飾プロフィールを誘発する規定されたヌクレオチド間結合との関連におけるrna配列モチーフ
JP2010536907A (ja) * 2007-08-31 2010-12-02 ニューリミューン セラピューティクス エイジー 患者にアミロイドーシスおよびタンパク質凝集性障害における特異的免疫応答をもたらす方法
WO2009105641A2 (en) 2008-02-20 2009-08-27 New York University Preventing and treating amyloid-beta deposition by stimulation of innate immunity
WO2013012875A2 (en) 2011-07-18 2013-01-24 Mount Sinai School Of Medicine Bacterial rnas as vaccine adjuvants
US10434064B2 (en) 2014-06-04 2019-10-08 Exicure, Inc. Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
EP3220895B1 (en) 2014-11-21 2022-08-31 Northwestern University The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
MX2020006243A (es) 2017-12-15 2020-09-03 Bayer Animal Health Gmbh Oligonucleotidos inmunoestimulantes.
WO2024030844A1 (en) * 2022-08-01 2024-02-08 University Of Mississippi Choline carboxylic acid based ionic liquids as antimicrobial agents

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817321A (en) * 1992-10-08 1998-10-06 Supratek Pharma, Inc. Biological agent compositions
IL112920A (en) * 1994-03-07 2003-04-10 Dow Chemical Co Composition comprising a dendritic polymer complexed with at least one unit of biological response modifier and a process for the preparation thereof
ID29546A (id) * 1999-02-15 2001-09-06 Nippon Shinyaku Co Ltd Polinukleotida dengan rantai yang diperpendek dan metode pembuatannya
RU2288921C2 (ru) * 2000-12-19 2006-12-10 Калифорниа Инститьют оф Текнолоджи Композиции, содержащие комплексы включения
RU2289410C2 (ru) * 2001-04-04 2006-12-20 Корикса Корпорейшн Профилактика и лечение инфекционных и других заболеваний с помощью соединений, основанных на моно- и дисахаридах
RU2185818C1 (ru) * 2001-07-10 2002-07-27 НИИ "Молекулярной медицины" Московской медицинской академии им. И.М. Сеченова Композиция для лечения легочных инфекций
IL160157A0 (en) * 2001-08-17 2004-07-25 Coley Pharm Group Inc Combination motif immune stimulation oligonucleotides with improved activity
EP1499187B1 (en) * 2002-04-04 2015-06-17 Zoetis Belgium S.A. Immunostimulatory g,u-containing oligoribonucleotides
CN1302948C (zh) 2002-04-12 2007-03-07 爱信艾达株式会社 车载装置用电源管理系统
DE10229872A1 (de) * 2002-07-03 2004-01-29 Curevac Gmbh Immunstimulation durch chemisch modifizierte RNA
US7956043B2 (en) * 2002-12-11 2011-06-07 Coley Pharmaceutical Group, Inc. 5′ CpG nucleic acids and methods of use
AU2004259204B2 (en) * 2003-07-15 2010-08-19 Idera Pharmaceuticals, Inc. Synergistic stimulation of the immune system using immunostimulatory oligonucleotides and/or immunomer compounds in conjunction with cytokines and/or chemotherapeutic agents or radiation therapy
US20050239733A1 (en) * 2003-10-31 2005-10-27 Coley Pharmaceutical Gmbh Sequence requirements for inhibitory oligonucleotides
CA2555390C (en) * 2004-02-19 2014-08-05 Coley Pharmaceutical Group, Inc. Immunostimulatory viral rna oligonucleotides
MY159370A (en) * 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
US8076068B2 (en) * 2005-09-14 2011-12-13 Gunther Hartmann Method for determining immunostimulatory activity of RNA oligonucleotides
ES2536103T3 (es) * 2005-11-25 2015-05-20 Zoetis Belgium S.A. Oligorribonucleótidos inmunoestimuladores
JP4847609B2 (ja) * 2007-08-13 2011-12-28 コーリー ファーマシューティカル ゲーエムベーハー 特異的な免疫修飾プロフィールを誘発する規定されたヌクレオチド間結合との関連におけるrna配列モチーフ

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JP2010536739A (ja) 2010-12-02
MX2010001014A (es) 2010-03-01
BRPI0814260B8 (pt) 2021-05-25
PL2179039T3 (pl) 2019-03-29
DK2179039T3 (en) 2019-01-07
WO2009022216A3 (en) 2009-06-04
BRPI0814260A2 (pt) 2015-03-31
EP2179039A2 (en) 2010-04-28
US8227447B2 (en) 2012-07-24
CN101821392A (zh) 2010-09-01
RU2435851C2 (ru) 2011-12-10
CL2008002371A1 (es) 2009-07-03
CO6260153A2 (es) 2011-03-22
HK1143741A1 (en) 2011-01-14
CA2696630C (en) 2014-04-01
RU2010104618A (ru) 2011-09-20
AR067928A1 (es) 2009-10-28
WO2009022216A9 (en) 2009-04-30
CN101821392B (zh) 2013-04-17
CA2696630A1 (en) 2009-02-19
US20120258140A1 (en) 2012-10-11
PT2179039T (pt) 2019-01-11
WO2009022216A2 (en) 2009-02-19
US20100272785A1 (en) 2010-10-28
SI2179039T1 (sl) 2019-01-31
AU2008288241A1 (en) 2009-02-19
US8128944B2 (en) 2012-03-06
US20120121648A1 (en) 2012-05-17
NZ582972A (en) 2011-09-30
TW200916106A (en) 2009-04-16
BRPI0814260B1 (pt) 2019-11-12
US8466124B2 (en) 2013-06-18
KR20100045508A (ko) 2010-05-03
ES2703876T3 (es) 2019-03-12
AU2008288241B2 (en) 2011-12-01
JP4847609B2 (ja) 2011-12-28
EP2179039B1 (en) 2018-10-31

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