TR201819543T4 - Hareketli hücrelerin analizi ve ayıklanması. - Google Patents
Hareketli hücrelerin analizi ve ayıklanması.Info
- Publication number
- TR201819543T4 TR201819543T4 TR2018/19543T TR201819543T TR201819543T4 TR 201819543 T4 TR201819543 T4 TR 201819543T4 TR 2018/19543 T TR2018/19543 T TR 2018/19543T TR 201819543 T TR201819543 T TR 201819543T TR 201819543 T4 TR201819543 T4 TR 201819543T4
- Authority
- TR
- Turkey
- Prior art keywords
- motile cells
- sorting
- cell population
- mobile cell
- analysis
- Prior art date
Links
- 210000000947 motile cell Anatomy 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 4
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/0612—Germ cells sorting of gametes, e.g. according to sex or motility
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1484—Electro-optical investigation, e.g. flow cytometers microstructural devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0694—Creating chemical gradients in a fluid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0858—Side walls
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- G01N15/01—
-
- G01N15/149—
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N2015/0003—Determining electric mobility, velocity profile, average speed or velocity of a plurality of particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N2015/0042—Investigating dispersion of solids
- G01N2015/0053—Investigating dispersion of solids in liquids, e.g. trouble
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/367—Infertility, e.g. sperm disorder, ovulatory dysfunction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Dispersion Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Sustainable Development (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Fluid Mechanics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Hareketli hücreleri ayıklamaya yönelik bir yöntem olup, bir ilk hareketli hücre popülasyonunu bir mikro akışkan kanalının bir giriş portuna sokmayı, burada ilk hareketli hücre popülasyonu bir birinci ortalama hareketliliğe sahiptir; hareketli hücre popülasyonunu mikro akışkan kanalında inkübe etmeyi ve ayıklanmış hareketli hücre popülasyonunu mikro akışkan kanalının bir çıkış portunda toplamayı içerir. Ayıklanmış hareketli hücre popülasyonunun, birinci ortalama hareketliliğinden daha yüksek bir ikinci ortalama hareketliliği vardır.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161488300P | 2011-05-20 | 2011-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201819543T4 true TR201819543T4 (tr) | 2019-01-21 |
Family
ID=47217995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2018/19543T TR201819543T4 (tr) | 2011-05-20 | 2012-05-18 | Hareketli hücrelerin analizi ve ayıklanması. |
Country Status (10)
Country | Link |
---|---|
US (3) | US20140248656A1 (tr) |
EP (1) | EP2710139B2 (tr) |
JP (2) | JP6196614B2 (tr) |
CN (2) | CN103781916A (tr) |
AU (1) | AU2012258999B2 (tr) |
BR (1) | BR112013029824A2 (tr) |
CA (1) | CA2836774C (tr) |
ES (1) | ES2702793T5 (tr) |
TR (1) | TR201819543T4 (tr) |
WO (1) | WO2012162181A2 (tr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102242055B (zh) * | 2011-06-03 | 2013-08-14 | 博奥生物有限公司 | 一种精子活力评价及筛选的方法及其专用微流控芯片装置 |
US9222874B2 (en) * | 2012-06-27 | 2015-12-29 | The United States Of America As Represented By The Secretary Of The Army | Systems and methods for individually trapping particles from air and measuring the optical spectra or other properties of individual trapped particles |
FR3002634B1 (fr) * | 2013-02-28 | 2015-04-10 | Commissariat Energie Atomique | Procede d'observation d'au moins un objet, tel qu'une entite biologique, et systeme d'imagerie associe |
US9757726B2 (en) | 2013-03-14 | 2017-09-12 | Inguran, Llc | System for high throughput sperm sorting |
US10662408B2 (en) | 2013-03-14 | 2020-05-26 | Inguran, Llc | Methods for high throughput sperm sorting |
KR101920732B1 (ko) * | 2013-03-14 | 2018-11-22 | 인구란, 엘엘씨 | 높은 처리량의 정자 분류 장치 및 방법 |
US10371622B2 (en) | 2013-03-14 | 2019-08-06 | Inguran, Llc | Device for high throughput sperm sorting |
WO2014177157A1 (en) | 2013-05-03 | 2014-11-06 | Motilitycount Aps | Device for analysis of cellular motility |
AU2014353050B2 (en) | 2013-11-20 | 2019-10-03 | Brigham And Women's Hospital, Inc. | System and method for sperm sorting |
US9574991B2 (en) * | 2014-10-14 | 2017-02-21 | Omnivision Technologies, Inc. | High-throughput fluorescence imaging system and device with sample heating capability, and associated methods |
CN105403499A (zh) * | 2015-12-31 | 2016-03-16 | 中国人民解放军第三军医大学第一附属医院 | 用于光学检测的单细胞流道装置 |
EP3239689B1 (en) * | 2016-04-26 | 2021-10-06 | Atten2 Advanced Monitoring Technologies S.L. | Fluid monitoring system |
WO2018104819A1 (en) | 2016-12-08 | 2018-06-14 | Sigtuple Technologies Private Limited | A method and system for evaluating quality of semen sample |
JP2020506699A (ja) | 2017-01-31 | 2020-03-05 | ジェネア アイピー ホールディングス ピーティーワイ リミテッド | 生体試料を処理するための方法およびシステム |
JP6871116B2 (ja) * | 2017-09-15 | 2021-05-12 | 株式会社東芝 | セルソータ |
WO2019064040A1 (en) * | 2017-09-29 | 2019-04-04 | Nanovare Sas | DEVICES AND METHODS FOR ANALYZING MALE INFERTILITY |
US11491485B2 (en) | 2018-04-09 | 2022-11-08 | Cornell University | Rheotaxis-based separation of motile sperm and bacteria using a microfluidic corral system |
CN109932290B (zh) * | 2019-01-16 | 2020-10-20 | 中国科学院水生生物研究所 | 一种基于流式影像运动目标追踪的颗粒计数方法 |
CN109828423A (zh) * | 2019-02-28 | 2019-05-31 | 西安理工大学 | 应用于无透镜成像装置的光源系统 |
JP6661039B1 (ja) * | 2019-03-28 | 2020-03-11 | 国立大学法人 東京大学 | 運動性細胞の選択装置 |
WO2021124111A1 (en) * | 2019-12-16 | 2021-06-24 | King Abdullah University Of Science And Technology | Microfluidic device for highly motile sperm selection |
CN111339904B (zh) * | 2020-02-21 | 2023-11-03 | 腾讯科技(深圳)有限公司 | 动物精子图像识别方法和装置 |
CN111323361B (zh) * | 2020-03-17 | 2022-05-10 | 南通大学 | 一种快速分离精子头、精子尾和正常有活力精子的方法 |
EP4005672A1 (en) * | 2020-11-25 | 2022-06-01 | Pera Labs Medikal Arastirma ve Gelistirme Limited Sirketi | A device for separating and analyzing seminal sample, system and method |
US20220397513A1 (en) * | 2021-06-14 | 2022-12-15 | Becton, Dickinson And Company | Clamps for applying an immobilizing force to a photodetector, and systems and methods for using the same |
FR3136479A1 (fr) | 2022-06-13 | 2023-12-15 | Béez Biotech | Dispositif d’isolement de cellules de sperme et procédé de sélection de cellules de sperme de haute qualité |
WO2024026018A2 (en) * | 2022-07-27 | 2024-02-01 | The Trustees Of The University Of Columbia In The City Of New York | Systems and methods for identifying and recovering rare biological cells from a sample |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5296375A (en) * | 1992-05-01 | 1994-03-22 | Trustees Of The University Of Pennsylvania | Mesoscale sperm handling devices |
IT1307787B1 (it) * | 1999-07-26 | 2001-11-19 | Univ Firenze | Processo per incrementare la motilita' degli spermatozoi e spermatozoia motilita' superiore cosi' ottenuti. |
AT410280B (de) † | 2001-10-05 | 2003-03-25 | Zech Josef Dr | Einrichtung zur gewinnung von samenzellen aus samenflüssigkeit |
AU2003219836A1 (en) * | 2002-02-27 | 2003-09-09 | The Regents Of The University Of Michigan | Process for sorting motile particles from lesser-motile particles and apparatus suitable therefor |
EP1641411A1 (en) * | 2003-06-06 | 2006-04-05 | The Regents Of The University Of Michigan | Integrated microfluidic sperm isolation and insemination device |
US20060270021A1 (en) | 2004-06-07 | 2006-11-30 | Shuichi Takayama | Integrated microfluidic sperm isolation and insemination device |
US8369141B2 (en) * | 2007-03-12 | 2013-02-05 | Apple Inc. | Adaptive estimation of memory cell read thresholds |
CA2740113C (en) † | 2008-10-10 | 2019-12-24 | The Governing Council Of The University Of Toronto | Hybrid digital and channel microfluidic devices and methods of use thereof |
EP2414539B1 (en) * | 2009-04-03 | 2020-12-16 | The Regents of The University of California | Apparatus and method for sorting cells and other biological particulates |
TW201040524A (en) | 2009-05-15 | 2010-11-16 | Nat Univ Tsing Hua | Method of using microfluidic chip to sort high motility sperm |
-
2012
- 2012-05-18 CA CA2836774A patent/CA2836774C/en active Active
- 2012-05-18 ES ES12790268T patent/ES2702793T5/es active Active
- 2012-05-18 JP JP2014511597A patent/JP6196614B2/ja active Active
- 2012-05-18 CN CN201280035984.6A patent/CN103781916A/zh active Pending
- 2012-05-18 CN CN201810447060.6A patent/CN108889345B/zh active Active
- 2012-05-18 BR BR112013029824A patent/BR112013029824A2/pt not_active Application Discontinuation
- 2012-05-18 US US14/118,809 patent/US20140248656A1/en not_active Abandoned
- 2012-05-18 TR TR2018/19543T patent/TR201819543T4/tr unknown
- 2012-05-18 EP EP12790268.2A patent/EP2710139B2/en active Active
- 2012-05-18 WO PCT/US2012/038680 patent/WO2012162181A2/en active Application Filing
- 2012-05-18 AU AU2012258999A patent/AU2012258999B2/en active Active
-
2017
- 2017-04-13 JP JP2017079547A patent/JP2017169570A/ja active Pending
-
2019
- 2019-04-23 US US16/392,146 patent/US20190316084A1/en not_active Abandoned
-
2021
- 2021-08-20 US US17/407,609 patent/US20220073872A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2710139B2 (en) | 2022-04-13 |
ES2702793T3 (es) | 2019-03-05 |
BR112013029824A2 (pt) | 2016-09-06 |
AU2012258999B2 (en) | 2016-11-17 |
JP2017169570A (ja) | 2017-09-28 |
ES2702793T5 (es) | 2022-07-15 |
EP2710139A4 (en) | 2014-10-29 |
JP6196614B2 (ja) | 2017-09-13 |
WO2012162181A2 (en) | 2012-11-29 |
WO2012162181A3 (en) | 2013-01-17 |
US20190316084A1 (en) | 2019-10-17 |
US20140248656A1 (en) | 2014-09-04 |
CN108889345B (zh) | 2020-10-09 |
CN103781916A (zh) | 2014-05-07 |
EP2710139A2 (en) | 2014-03-26 |
EP2710139B1 (en) | 2018-09-19 |
CA2836774C (en) | 2023-07-04 |
CA2836774A1 (en) | 2012-11-29 |
CN108889345A (zh) | 2018-11-27 |
US20220073872A1 (en) | 2022-03-10 |
JP2014518627A (ja) | 2014-08-07 |
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