TR200202439T2 - Sodium hydrogen exchanger type 1 inhibitor (NHE-1) - Google Patents

Sodium hydrogen exchanger type 1 inhibitor (NHE-1)

Info

Publication number
TR200202439T2
TR200202439T2 TR2002/02439T TR200202439T TR200202439T2 TR 200202439 T2 TR200202439 T2 TR 200202439T2 TR 2002/02439 T TR2002/02439 T TR 2002/02439T TR 200202439 T TR200202439 T TR 200202439T TR 200202439 T2 TR200202439 T2 TR 200202439T2
Authority
TR
Turkey
Prior art keywords
inhibitor
nhe
sodium hydrogen
exchanger type
hydrogen exchanger
Prior art date
Application number
TR2002/02439T
Other languages
Turkish (tr)
Inventor
George Chen Weichao
David Cox Eric
Guzman-Perez Angel
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of TR200202439T2 publication Critical patent/TR200202439T2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NHE-1 önleyici, NHE-1 önleyici kullanma yöntemleri ve NHE-1 önleyici içeren farmasötik bilesikler. NHE-1 önleyici, doku iskemisinden kaynaklanan doku hasarinin azaltilmasinda yararlidir.Pharmaceutical compounds containing NHE-1 inhibitor, methods of using NHE-1 inhibitor, and NHE-1 inhibitor. The NHE-1 inhibitor is useful in reducing tissue damage caused by tissue ischemia.

TR2002/02439T 2000-04-28 2001-02-28 Sodium hydrogen exchanger type 1 inhibitor (NHE-1) TR200202439T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20043200P 2000-04-28 2000-04-28

Publications (1)

Publication Number Publication Date
TR200202439T2 true TR200202439T2 (en) 2003-02-21

Family

ID=22741697

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/02439T TR200202439T2 (en) 2000-04-28 2001-02-28 Sodium hydrogen exchanger type 1 inhibitor (NHE-1)

Country Status (40)

Country Link
EP (1) EP1276737A1 (en)
JP (1) JP2003531900A (en)
KR (1) KR20020093079A (en)
CN (1) CN1225466C (en)
AP (1) AP2002002651A0 (en)
AR (1) AR028375A1 (en)
AU (1) AU2001235896A1 (en)
BG (1) BG107139A (en)
BR (1) BR0110268A (en)
CA (1) CA2407535A1 (en)
CO (1) CO5221125A1 (en)
CR (1) CR6797A (en)
CZ (1) CZ20023408A3 (en)
DZ (1) DZ3310A1 (en)
EA (1) EA004882B1 (en)
EE (1) EE200200615A (en)
GT (1) GT200100064A (en)
HN (1) HN2001000042A (en)
HR (1) HRP20020851A2 (en)
HU (1) HUP0300651A2 (en)
IL (1) IL152075A0 (en)
IS (2) IS6567A (en)
MA (1) MA26897A1 (en)
MX (1) MXPA02010600A (en)
MY (1) MY133842A (en)
NO (1) NO20025132L (en)
NZ (1) NZ521348A (en)
OA (1) OA12256A (en)
PA (1) PA8513301A1 (en)
PE (1) PE20011270A1 (en)
PL (1) PL357765A1 (en)
SK (1) SK14872002A3 (en)
SV (1) SV2002000418A (en)
TN (1) TNSN01065A1 (en)
TR (1) TR200202439T2 (en)
UA (1) UA73348C2 (en)
UY (1) UY26680A1 (en)
WO (1) WO2001083470A1 (en)
YU (1) YU79602A (en)
ZA (1) ZA200208605B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060892A1 (en) * 2001-01-31 2002-08-08 Pfizer Products Inc. Ethanolates of sodium-hydrogen exchanger type-1 inhibitor
CA2469305A1 (en) * 2001-12-19 2003-06-26 Frank Robert Busch Methods for preparing sodium-hydrogen exchanger type-1 inhibitors
CA2483927A1 (en) * 2002-05-02 2003-11-13 Pfizer Products Inc. Treatment of diabetes and diabetic complications with nhe-1 inhibitors
FR2840302B1 (en) * 2002-06-03 2004-07-16 Aventis Pharma Sa ISOINDOLONE DERIVATIVES, PREPARATION METHOD AND INTERMEDIARY THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
ES2220185B1 (en) * 2002-07-16 2006-04-01 Consejo Sup. De Investig. Cientificas NEW INHIBITOR PEPTIDE OF THE NA + / H + EXCHANGER (PINHE), AND ITS APPLICATIONS.
EP1596860A4 (en) * 2003-02-14 2009-05-27 Smithkline Beecham Corp Novel compounds
RU2518741C1 (en) * 2013-03-22 2014-06-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" MEDICATION, INHIBITING Na+/H+-EXCHANGE, AND HALOGENIDES OF 1-DIALKYLAMINOETHYL-3-[SUBSTITUTED(DISUBSTITUTED)PHENACYL]-2-AMINOBENZIMIDAZOLIUM

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU739403B2 (en) * 1998-02-27 2001-10-11 Pfizer Products Inc. N-((substituted five-membered di- or triaza diunsaturated ring)carbonyl) guanidine derivatives for the treatment of ischemia

Also Published As

Publication number Publication date
UY26680A1 (en) 2001-12-28
OA12256A (en) 2003-11-06
CR6797A (en) 2004-05-17
MXPA02010600A (en) 2003-03-10
IS6588A (en) 2002-10-21
TNSN01065A1 (en) 2005-11-10
DZ3310A1 (en) 2001-11-07
IS6567A (en) 2002-09-24
JP2003531900A (en) 2003-10-28
CO5221125A1 (en) 2002-11-28
PL357765A1 (en) 2004-07-26
IL152075A0 (en) 2003-05-29
EP1276737A1 (en) 2003-01-22
NO20025132D0 (en) 2002-10-25
PE20011270A1 (en) 2001-12-12
MA26897A1 (en) 2004-12-20
YU79602A (en) 2006-05-25
NZ521348A (en) 2004-09-24
UA73348C2 (en) 2005-07-15
NO20025132L (en) 2002-12-12
CN1426404A (en) 2003-06-25
KR20020093079A (en) 2002-12-12
AU2001235896A1 (en) 2001-11-12
AP2002002651A0 (en) 2002-12-31
GT200100064A (en) 2002-03-22
HN2001000042A (en) 2001-07-09
EE200200615A (en) 2004-04-15
HUP0300651A2 (en) 2003-07-28
CA2407535A1 (en) 2001-11-08
HRP20020851A2 (en) 2005-02-28
BG107139A (en) 2003-07-31
ZA200208605B (en) 2003-10-24
EA200201023A1 (en) 2003-02-27
SV2002000418A (en) 2002-07-03
WO2001083470A1 (en) 2001-11-08
CN1225466C (en) 2005-11-02
BR0110268A (en) 2003-12-30
SK14872002A3 (en) 2004-03-02
PA8513301A1 (en) 2003-09-05
EA004882B1 (en) 2004-08-26
AR028375A1 (en) 2003-05-07
MY133842A (en) 2007-11-30
CZ20023408A3 (en) 2004-01-14

Similar Documents

Publication Publication Date Title
NO20011023L (en) Arylpiperazines and their Use as Metalloproteinase Inhibitors (MMP)
BR0311132A (en) Hepatitis C Virus Inhibitors
NO971537L (en) Peptidyl compounds and their therapeutic use as inhibitors of metalloproteases
UY27972A1 (en) HIDANTOINE DERIVATIVES
ATE246681T1 (en) SULFONAMIDES
BR0110101A (en) Apoptosis promoting N-acyl sulfonamides
DK0931788T3 (en) metalloprotease
SE0004245D0 (en) Novel compounds and their use
DE60112306D1 (en) CONDENSED PYRAZINDION DERIVATIVES AS PDE5 INHIBITORS
ATE333457T1 (en) CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS
TR200202439T2 (en) Sodium hydrogen exchanger type 1 inhibitor (NHE-1)
TR200001909T2 (en) Matrix metalloprosthesis inhibitors.
NO20015892L (en) Inhibitors of metal proteinases
DK1204659T3 (en) Serotonergic benzofurans
ATE320422T1 (en) METALLOPROTEINASE INHIBITORS
BRPI0415034A (en) aminopyridine derivatives as inducible non-synthase inhibitors
NO20023951L (en) Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibitors
DE60121048D1 (en) PYRAZINOi1'2 ': 1,6öPYRIDOi3,4-BöINDOLDERIVATE
BR0110902A (en) Mmp-9 / mmp-2 inhibitors
ATE348800T1 (en) 4'-METHANSULFONYLBIPHENYL DERIVATIVES AS HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITORS
BR0107204A (en) Hydrazide and alkoxyamide angiogenesis inhibitors
TR200201167T2 (en) Sodium-hydrogen exchanger type 1 inhibitor crystals.
DE60119949D1 (en) 1,2,5,10-TETRAHYDROPYRIDAZINOi4,5-BOCHINOLINE-1,10-DIONE AND THEIR USE IN THE TREATMENT OF PAIN
ATE293605T1 (en) FLUORINATED 3,4-DIHYDROCINOLINE DERIVATIVES AS NOS INHIBITORS
UY26417A1 (en) TYPE 1 SODIUM-HYDROGEN EXCHANGER INHIBITOR CRYSTALS