EA200201023A1 - SODIUM HYDROGEN EXCHANGE TYPE 1 (NHE-1) INHIBITOR - Google Patents

SODIUM HYDROGEN EXCHANGE TYPE 1 (NHE-1) INHIBITOR

Info

Publication number
EA200201023A1
EA200201023A1 EA200201023A EA200201023A EA200201023A1 EA 200201023 A1 EA200201023 A1 EA 200201023A1 EA 200201023 A EA200201023 A EA 200201023A EA 200201023 A EA200201023 A EA 200201023A EA 200201023 A1 EA200201023 A1 EA 200201023A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nhe
inhibitor
sodium hydrogen
exchange type
hydrogen exchange
Prior art date
Application number
EA200201023A
Other languages
Russian (ru)
Other versions
EA004882B1 (en
Inventor
Вейчао Джордж Чен
Эрик Дэвид Кокс
Энджел Гусман-Перес
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200201023A1 publication Critical patent/EA200201023A1/en
Publication of EA004882B1 publication Critical patent/EA004882B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ингибитор NHE-1, способы применения ингибитора NHE-1 и фармацевтические композиции, содержащие ингибитор NHE-1. Ингибитор NHE-1, полезный для снижения поражения ткани в результате ишемии ткани.Международная заявка была опубликована вместе с отчетом о международном поиске.NHE-1 inhibitor, methods of using the NHE-1 inhibitor and pharmaceutical compositions containing the NHE-1 inhibitor. NHE-1 inhibitor, useful for reducing tissue damage due to tissue ischemia. The international application was published along with an international search report.

EA200201023A 2000-04-28 2001-02-28 Sodium-hydrogen-exchanger type 1 inhibitor (nhe-1) EA004882B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20043200P 2000-04-28 2000-04-28
PCT/IB2001/000277 WO2001083470A1 (en) 2000-04-28 2001-02-28 Sodium-hydrogen exchanger type 1 inhibitor (nhe-1)

Publications (2)

Publication Number Publication Date
EA200201023A1 true EA200201023A1 (en) 2003-02-27
EA004882B1 EA004882B1 (en) 2004-08-26

Family

ID=22741697

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200201023A EA004882B1 (en) 2000-04-28 2001-02-28 Sodium-hydrogen-exchanger type 1 inhibitor (nhe-1)

Country Status (40)

Country Link
EP (1) EP1276737A1 (en)
JP (1) JP2003531900A (en)
KR (1) KR20020093079A (en)
CN (1) CN1225466C (en)
AP (1) AP2002002651A0 (en)
AR (1) AR028375A1 (en)
AU (1) AU2001235896A1 (en)
BG (1) BG107139A (en)
BR (1) BR0110268A (en)
CA (1) CA2407535A1 (en)
CO (1) CO5221125A1 (en)
CR (1) CR6797A (en)
CZ (1) CZ20023408A3 (en)
DZ (1) DZ3310A1 (en)
EA (1) EA004882B1 (en)
EE (1) EE200200615A (en)
GT (1) GT200100064A (en)
HN (1) HN2001000042A (en)
HR (1) HRP20020851A2 (en)
HU (1) HUP0300651A2 (en)
IL (1) IL152075A0 (en)
IS (2) IS6567A (en)
MA (1) MA26897A1 (en)
MX (1) MXPA02010600A (en)
MY (1) MY133842A (en)
NO (1) NO20025132L (en)
NZ (1) NZ521348A (en)
OA (1) OA12256A (en)
PA (1) PA8513301A1 (en)
PE (1) PE20011270A1 (en)
PL (1) PL357765A1 (en)
SK (1) SK14872002A3 (en)
SV (1) SV2002000418A (en)
TN (1) TNSN01065A1 (en)
TR (1) TR200202439T2 (en)
UA (1) UA73348C2 (en)
UY (1) UY26680A1 (en)
WO (1) WO2001083470A1 (en)
YU (1) YU79602A (en)
ZA (1) ZA200208605B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2518741C1 (en) * 2013-03-22 2014-06-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" MEDICATION, INHIBITING Na+/H+-EXCHANGE, AND HALOGENIDES OF 1-DIALKYLAMINOETHYL-3-[SUBSTITUTED(DISUBSTITUTED)PHENACYL]-2-AMINOBENZIMIDAZOLIUM

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2436539A1 (en) * 2001-01-31 2002-08-08 Pfizer Products Inc. Ethanolates of sodium-hydrogen exchanger type-1 inhibitor
JP2005511787A (en) * 2001-12-19 2005-04-28 ファイザー・プロダクツ・インク Method for preparing sodium-hydrogen exchange type 1 inhibitor
EP1499317A1 (en) * 2002-05-02 2005-01-26 Pfizer Products Inc. Treatment of diabetes and diabetic complications with nhe-1 inhibitors
FR2840302B1 (en) * 2002-06-03 2004-07-16 Aventis Pharma Sa ISOINDOLONE DERIVATIVES, PREPARATION METHOD AND INTERMEDIARY THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
ES2220185B1 (en) * 2002-07-16 2006-04-01 Consejo Sup. De Investig. Cientificas NEW INHIBITOR PEPTIDE OF THE NA + / H + EXCHANGER (PINHE), AND ITS APPLICATIONS.
AU2004212957A1 (en) * 2003-02-14 2004-09-02 Smithkline Beecham Corporation Novel compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1454902A1 (en) * 1998-02-27 2004-09-08 Pfizer Products Inc. N- (substituted five-membered di-or triaza diunsaturated ring)carbonyl guanidine derivateives for the treatment of ischemia

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2518741C1 (en) * 2013-03-22 2014-06-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" MEDICATION, INHIBITING Na+/H+-EXCHANGE, AND HALOGENIDES OF 1-DIALKYLAMINOETHYL-3-[SUBSTITUTED(DISUBSTITUTED)PHENACYL]-2-AMINOBENZIMIDAZOLIUM

Also Published As

Publication number Publication date
CN1426404A (en) 2003-06-25
ZA200208605B (en) 2003-10-24
NZ521348A (en) 2004-09-24
MXPA02010600A (en) 2003-03-10
PA8513301A1 (en) 2003-09-05
IL152075A0 (en) 2003-05-29
WO2001083470A1 (en) 2001-11-08
NO20025132L (en) 2002-12-12
EE200200615A (en) 2004-04-15
TNSN01065A1 (en) 2005-11-10
CZ20023408A3 (en) 2004-01-14
UA73348C2 (en) 2005-07-15
NO20025132D0 (en) 2002-10-25
SV2002000418A (en) 2002-07-03
EA004882B1 (en) 2004-08-26
AU2001235896A1 (en) 2001-11-12
IS6567A (en) 2002-09-24
EP1276737A1 (en) 2003-01-22
IS6588A (en) 2002-10-21
HUP0300651A2 (en) 2003-07-28
DZ3310A1 (en) 2001-11-07
CA2407535A1 (en) 2001-11-08
UY26680A1 (en) 2001-12-28
BR0110268A (en) 2003-12-30
BG107139A (en) 2003-07-31
CN1225466C (en) 2005-11-02
HRP20020851A2 (en) 2005-02-28
MA26897A1 (en) 2004-12-20
YU79602A (en) 2006-05-25
SK14872002A3 (en) 2004-03-02
OA12256A (en) 2003-11-06
AP2002002651A0 (en) 2002-12-31
TR200202439T2 (en) 2003-02-21
AR028375A1 (en) 2003-05-07
KR20020093079A (en) 2002-12-12
MY133842A (en) 2007-11-30
HN2001000042A (en) 2001-07-09
PE20011270A1 (en) 2001-12-12
GT200100064A (en) 2002-03-22
CO5221125A1 (en) 2002-11-28
JP2003531900A (en) 2003-10-28
PL357765A1 (en) 2004-07-26
CR6797A (en) 2004-05-17

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU