TR200101756T2 - Protein kinaz inhibitörleri olarak 4,5-pirazinoksindoller. - Google Patents

Protein kinaz inhibitörleri olarak 4,5-pirazinoksindoller.

Info

Publication number
TR200101756T2
TR200101756T2 TR2001/01756T TR200101756T TR200101756T2 TR 200101756 T2 TR200101756 T2 TR 200101756T2 TR 2001/01756 T TR2001/01756 T TR 2001/01756T TR 200101756 T TR200101756 T TR 200101756T TR 200101756 T2 TR200101756 T2 TR 200101756T2
Authority
TR
Turkey
Prior art keywords
pyrazinoxindoles
protein kinase
kinase inhibitors
protein kinases
formula
Prior art date
Application number
TR2001/01756T
Other languages
English (en)
Turkish (tr)
Inventor
Luk Kin-Chun
Michoud Christophe
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200101756T2 publication Critical patent/TR200101756T2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TR2001/01756T 1998-12-17 1999-12-11 Protein kinaz inhibitörleri olarak 4,5-pirazinoksindoller. TR200101756T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11265398P 1998-12-17 1998-12-17

Publications (1)

Publication Number Publication Date
TR200101756T2 true TR200101756T2 (tr) 2001-10-22

Family

ID=22345140

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01756T TR200101756T2 (tr) 1998-12-17 1999-12-11 Protein kinaz inhibitörleri olarak 4,5-pirazinoksindoller.

Country Status (17)

Country Link
US (1) US6221867B1 (https=)
EP (1) EP1149105B1 (https=)
JP (1) JP2002532503A (https=)
KR (1) KR20010108024A (https=)
CN (1) CN1158283C (https=)
AR (1) AR021695A1 (https=)
AT (1) ATE387448T1 (https=)
AU (1) AU767138B2 (https=)
BR (1) BR9916324A (https=)
CA (1) CA2354402A1 (https=)
DE (1) DE69938258T2 (https=)
ES (1) ES2301255T3 (https=)
PE (1) PE20001385A1 (https=)
TR (1) TR200101756T2 (https=)
UY (1) UY25854A1 (https=)
WO (1) WO2000035921A1 (https=)
ZA (1) ZA200104505B (https=)

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JP4414219B2 (ja) 2001-07-23 2010-02-10 メルク セローノ ソシエテ アノニム Ｃ−ｊｕｎ−ｎ−末端キナーゼ（ｊｎｋ）インヒビターとしてのアリールスルホンアミド誘導体
ATE465153T1 (de) 2002-02-28 2010-05-15 Eisai R&D Man Co Ltd Neue indazolverbindungen mit kondensiertem ring
DE60316542T2 (de) 2002-03-28 2008-07-03 Eisai R&D Management Co., Ltd. 7-azaindole als inhibitoren c-jun n-terminaler kinasen zur behandlung neurodegenerativer störungen
WO2003082869A1 (en) 2002-03-28 2003-10-09 Eisai Co., Ltd. Azaindoles as inhibitors of c-jun n-terminal kinases
CA2486183C (en) * 2002-05-23 2012-01-10 Cytopia Pty Ltd. Protein kinase inhibitors
US7429609B2 (en) 2002-05-31 2008-09-30 Eisai R & D Management Co., Ltd. Pyrazole compound and medicinal composition containing the same
WO2003106455A1 (en) 2002-06-14 2003-12-24 Applied Research Systems Ars Holding N.V. Azole methylidene cyanide derivatives and their use as protein kinase modulators
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
BRPI0410071A (pt) * 2003-05-08 2006-05-23 Wyeth Corp métodos para usar no diagnóstico e prognóstico da artrite em um paciente, para usar no monitoramento do curso da artrite em um paciente, para avaliar a eficácia de um tratamento para artrite em um paciente, para triar um composto capaz de inibir a artrite em um paciente e para tratar artrite em um paciente, e, molécula de sirna
US7612086B2 (en) 2003-05-16 2009-11-03 Eisai R & D Management Co. Ltd. JNK inhibitors
RU2006117635A (ru) 2003-10-24 2007-12-10 Шеринг Акциенгезельшафт (De) Производные индолинона и их применение для лечения патологических состояний, таких как злокачественное новообразование
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
US7968572B2 (en) 2005-10-03 2011-06-28 Ono Pharmaceuticals Co., Ltd. Nitrogen-containing heterocyclic compound and pharmaceutical application thereof
CA2633980A1 (en) 2005-12-29 2007-07-12 Anthrogenesis Corporation Improved composition for collecting and preserving placental stem cells and methods of using the composition

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GB9115160D0 (en) 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
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GB9507298D0 (en) * 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
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AU709191B2 (en) 1995-09-11 1999-08-26 Osteoarthritis Sciences, Inc. Protein tyrosine kinase inhibitors for treating osteoarthritis
US5733920A (en) 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
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GB9610964D0 (en) 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors
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Also Published As

Publication number Publication date
ES2301255T3 (es) 2008-06-16
CN1158283C (zh) 2004-07-21
DE69938258D1 (de) 2008-04-10
WO2000035921A1 (en) 2000-06-22
UY25854A1 (es) 2001-07-31
ZA200104505B (en) 2002-10-04
ATE387448T1 (de) 2008-03-15
US6221867B1 (en) 2001-04-24
EP1149105A1 (en) 2001-10-31
AU767138B2 (en) 2003-10-30
AU1977300A (en) 2000-07-03
CN1330653A (zh) 2002-01-09
JP2002532503A (ja) 2002-10-02
CA2354402A1 (en) 2000-06-22
EP1149105B1 (en) 2008-02-27
BR9916324A (pt) 2001-10-02
KR20010108024A (ko) 2001-12-07
PE20001385A1 (es) 2000-12-14
DE69938258T2 (de) 2009-02-26
AR021695A1 (es) 2002-07-31

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