TR200101182T2 - Delivery of dry powder active substance to the lung. - Google Patents

Delivery of dry powder active substance to the lung.

Info

Publication number
TR200101182T2
TR200101182T2 TR2001/01182T TR200101182T TR200101182T2 TR 200101182 T2 TR200101182 T2 TR 200101182T2 TR 2001/01182 T TR2001/01182 T TR 2001/01182T TR 200101182 T TR200101182 T TR 200101182T TR 200101182 T2 TR200101182 T2 TR 200101182T2
Authority
TR
Turkey
Prior art keywords
active substance
lung
dry powder
delivery
powder active
Prior art date
Application number
TR2001/01182T
Other languages
Turkish (tr)
Inventor
Clark Andrew
Kuo Mei-Chang
Lalor Cecily
John Aldous Barry
Original Assignee
Inhale Therapeutic Systems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhale Therapeutic Systems, Inc. filed Critical Inhale Therapeutic Systems, Inc.
Publication of TR200101182T2 publication Critical patent/TR200101182T2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Bu bulus partikülat terkipleriyle ve bir aktif maddenin, bir hastanin akcigerine iletim yöntemleriyle ilgilidir. Aktif madde kuru toz halinde olup, özellikle simüle akciger kosullari altinda, (i) düsük nem emme, ve (ii) hidroskopik büyümeye direnç gösterme özellikleri vardir.This invention relates to particulate preparations and methods of delivering an active substance to the lung of a patient. The active substance is in dry powder form, especially under simulated lung conditions, it has (i) low moisture absorption and (ii) resistance to hydroscopic growth.

TR2001/01182T 1998-09-14 1999-09-13 Delivery of dry powder active substance to the lung. TR200101182T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10016398P 1998-09-14 1998-09-14

Publications (1)

Publication Number Publication Date
TR200101182T2 true TR200101182T2 (en) 2001-09-21

Family

ID=22278404

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01182T TR200101182T2 (en) 1998-09-14 1999-09-13 Delivery of dry powder active substance to the lung.

Country Status (44)

Country Link
EP (1) EP1117442A1 (en)
JP (1) JP2002524535A (en)
KR (1) KR20010075063A (en)
CN (1) CN1317977A (en)
AP (1) AP1374A (en)
AR (1) AR022090A1 (en)
AU (1) AU753014B2 (en)
BG (1) BG105430A (en)
BR (1) BR9913722A (en)
CA (1) CA2343920A1 (en)
CO (1) CO5130023A1 (en)
CZ (1) CZ2001829A3 (en)
DZ (1) DZ2892A1 (en)
EA (1) EA003476B1 (en)
EE (1) EE200100151A (en)
GE (1) GEP20043257B (en)
GT (1) GT199900156A (en)
HK (1) HK1042231A1 (en)
HN (1) HN1999000159A (en)
HR (1) HRP20010189A2 (en)
HU (1) HUP0103837A3 (en)
ID (1) ID28845A (en)
IL (2) IL141562A0 (en)
IS (1) IS5878A (en)
LT (1) LT4897B (en)
LV (1) LV12658B (en)
MA (1) MA25590A1 (en)
MY (1) MY129282A (en)
NO (1) NO20011251L (en)
NZ (1) NZ510168A (en)
OA (1) OA11781A (en)
PA (1) PA8481901A1 (en)
PE (1) PE20001061A1 (en)
PL (1) PL195574B1 (en)
SA (1) SA99200718B1 (en)
SK (1) SK3442001A3 (en)
TN (1) TNSN99173A1 (en)
TR (1) TR200101182T2 (en)
TW (1) TWI226248B (en)
UA (1) UA76085C2 (en)
UY (1) UY25711A1 (en)
WO (1) WO2000015262A1 (en)
YU (1) YU24201A (en)
ZA (1) ZA200101995B (en)

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US6630121B1 (en) 1999-06-09 2003-10-07 The Regents Of The University Of Colorado Supercritical fluid-assisted nebulization and bubble drying
US6475468B2 (en) * 2001-02-15 2002-11-05 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
US6737042B2 (en) * 2001-05-24 2004-05-18 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
PL373780A1 (en) 2002-02-25 2005-09-19 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
WO2004004798A2 (en) * 2002-07-03 2004-01-15 The Brigham And Women's Hospital, Inc. Central airway administration for systemic delivery of therapeutics
CA2511385A1 (en) * 2002-12-19 2004-07-22 Pharmacia Corporation Non-hygroscopic formulation comprising a hydroscopic drug
DE10338403A1 (en) * 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder formulation containing the CGRP antagonist 1- [N 2 - [3,5-dibromo-N - [[4- (3,4-dihydro-2 (1 H) -oxoquinazolin-3-yl] -1-piperidinyl] carbonyl] -D-tyrosyl] -L-lysyl] -4- (4-pyrindinyl) piperazine, process for its preparation and its use as inhalant
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
HUE042304T2 (en) * 2004-04-23 2019-06-28 Cydex Pharmaceuticals Inc DPI Formulation Containing Sulfoalkyl Ether Cyclodextrin
EP1853544A4 (en) 2005-02-24 2010-06-16 Diffusion Pharmaceuticals Llc Trans carotenoids, their synthesis, formulation and uses
JPWO2006095788A1 (en) * 2005-03-09 2008-08-14 小野薬品工業株式会社 Particles and formulations containing the particles
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
JP5465432B2 (en) 2005-10-26 2014-04-09 サイデックス・ファーマシューティカルズ・インコーポレイテッド Sulfoalkyl ether cyclodextrin composition and process for producing the same
US20100269819A1 (en) * 2006-08-14 2010-10-28 Sievers Robert E Human Powered Dry Powder Inhaler and Dry Powder Inhaler Compositions
WO2008050847A1 (en) * 2006-10-25 2008-05-02 Dainippon Sumitomo Pharma Co., Ltd. Granular preparation prevented from caking
EP1925295A1 (en) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stable powder formulation containing a new antichinolinergic agent
AU2008246305B2 (en) 2007-04-13 2013-03-21 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
US8206751B2 (en) 2007-10-31 2012-06-26 Diffusion Pharmaceuticals Llc Class of therapeutics that enhance small molecule diffusion
ES2661215T3 (en) * 2009-05-20 2018-03-28 Aeras Viral compositions; immunogens; spray dried; stable
EP2445339B1 (en) 2009-06-22 2019-08-07 Diffusion Pharmaceuticals LLC Diffusion enhancing compound and its use with a thrombolytic
ES2654945T3 (en) 2010-06-02 2018-02-15 Diffusion Pharmaceuticals Llc Oral formulations of trans bipolar carotenoids
AU2013255885C1 (en) * 2012-05-03 2018-04-26 Janssen Sciences Ireland Uc Polyinosinic-polycytidylic acid (poly (I:C)) formulations for the treatment of upper respiratory tract infections
WO2014074797A1 (en) * 2012-11-09 2014-05-15 Civitas Therapeutics, Inc. Ultra low density pulmonary powders
US20180043585A9 (en) * 2013-09-20 2018-02-15 Virginia Commonwealth University Delivery of particles using hygroscopic excipients
CN107106641B (en) 2014-10-31 2021-12-21 葛兰素史密斯克莱知识产权发展有限公司 Powder formulation
CN109152839A (en) 2016-03-24 2019-01-04 扩散药品有限公司 Purposes of the bipolarity trans-carotenoid together with chemotherapy and radiotherapy in treating cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
ES2177544T3 (en) * 1992-06-12 2002-12-16 Teijin Ltd ULTRAFININE POWDER TO INHALATE AND METHOD FOR PREPARATION.
US6524557B1 (en) * 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
ES2236832T3 (en) * 1997-01-16 2005-07-16 Massachusetts Institute Of Technology PREPARATION OF PARTICLES FOR INHALATION.
US6086376A (en) * 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant

Also Published As

Publication number Publication date
EA200100300A1 (en) 2001-10-22
TWI226248B (en) 2005-01-11
GT199900156A (en) 2001-03-07
NZ510168A (en) 2003-09-26
PA8481901A1 (en) 2002-04-25
NO20011251L (en) 2001-04-17
HUP0103837A3 (en) 2002-11-28
ID28845A (en) 2001-07-05
UY25711A1 (en) 1999-11-17
HRP20010189A2 (en) 2005-04-30
OA11781A (en) 2005-07-26
SK3442001A3 (en) 2001-11-06
AP1374A (en) 2005-02-28
WO2000015262A1 (en) 2000-03-23
LV12658B (en) 2001-09-20
DZ2892A1 (en) 2003-12-15
CZ2001829A3 (en) 2001-09-12
TNSN99173A1 (en) 2005-11-10
SA99200718B1 (en) 2006-11-04
HN1999000159A (en) 1999-11-11
CO5130023A1 (en) 2002-02-27
BG105430A (en) 2001-12-29
LT2001021A (en) 2001-11-26
LT4897B (en) 2002-02-25
LV12658A (en) 2001-05-20
AP2001002093A0 (en) 2001-03-31
NO20011251D0 (en) 2001-03-13
YU24201A (en) 2003-08-29
IL141562A (en) 2007-07-24
EE200100151A (en) 2002-06-17
AR022090A1 (en) 2002-09-04
MY129282A (en) 2007-03-30
IL141562A0 (en) 2002-03-10
AU753014B2 (en) 2002-10-03
JP2002524535A (en) 2002-08-06
PE20001061A1 (en) 2000-10-08
MA25590A1 (en) 2002-12-31
EP1117442A1 (en) 2001-07-25
HUP0103837A2 (en) 2002-05-29
GEP20043257B (en) 2004-06-25
PL346768A1 (en) 2002-02-25
AU6039799A (en) 2000-04-03
PL195574B1 (en) 2007-10-31
KR20010075063A (en) 2001-08-09
CN1317977A (en) 2001-10-17
CA2343920A1 (en) 2000-03-23
ZA200101995B (en) 2002-03-11
HK1042231A1 (en) 2002-08-09
BR9913722A (en) 2001-05-29
EA003476B1 (en) 2003-06-26
UA76085C2 (en) 2006-07-17
IS5878A (en) 2001-03-05

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