EA200100300A1 - DRY POWDER CONTAINING EXISTING SUBSTANCE, AND METHOD OF DELIVERY TO LIGHT PATIENT OF EXISTING SUBSTANCE - Google Patents
DRY POWDER CONTAINING EXISTING SUBSTANCE, AND METHOD OF DELIVERY TO LIGHT PATIENT OF EXISTING SUBSTANCEInfo
- Publication number
- EA200100300A1 EA200100300A1 EA200100300A EA200100300A EA200100300A1 EA 200100300 A1 EA200100300 A1 EA 200100300A1 EA 200100300 A EA200100300 A EA 200100300A EA 200100300 A EA200100300 A EA 200100300A EA 200100300 A1 EA200100300 A1 EA 200100300A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- existing substance
- dry powder
- delivery
- powder containing
- patient
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
В изобретении предложены порошковые композиции и способы доставки действующего вещества в легкие пациента. Состав действующего вещества в виде сухого порошка имеет как низкую сорбцию влаги, так и стойкость к гигроскопическому росту, в особенности при имитации условий в легких пациента.Международная заявка была опубликована вместе с отчетом о международном поиске.The invention provides powder compositions and methods for delivering the active substance to the patient’s lungs. The composition of the active substance in the form of a dry powder has both low moisture sorption and resistance to hygroscopic growth, especially when simulating conditions in the patient's lungs. The international application was published along with an international search report.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10016398P | 1998-09-14 | 1998-09-14 | |
PCT/US1999/021109 WO2000015262A1 (en) | 1998-09-14 | 1999-09-13 | Dry powder active agent pulmonary delivery |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200100300A1 true EA200100300A1 (en) | 2001-10-22 |
EA003476B1 EA003476B1 (en) | 2003-06-26 |
Family
ID=22278404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100300A EA003476B1 (en) | 1998-09-14 | 1999-09-13 | Dry powder active agent pulmonary delivery |
Country Status (44)
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4874483B2 (en) | 1999-06-09 | 2012-02-15 | ロバート イー. シーバース | Supercritical fluid assisted nebulization and bubble drying |
US6475468B2 (en) * | 2001-02-15 | 2002-11-05 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
JP2005503425A (en) * | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | Delivery of drug ester by the prescribed inhalation route |
EG24184A (en) * | 2001-06-15 | 2008-10-08 | Otsuka Pharma Co Ltd | Dry powder inhalation system for transpulmonary |
US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
NZ535323A (en) | 2002-02-25 | 2008-02-29 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
AU2003232081B2 (en) * | 2002-07-03 | 2009-02-05 | Brandeis University | Central airway administration for systemic delivery of therapeutics |
JP2006513238A (en) * | 2002-12-19 | 2006-04-20 | ファルマシア・コーポレーション | Non-hygroscopic formulations containing hygroscopic drugs |
DE10338403A1 (en) * | 2003-08-18 | 2005-03-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder formulation containing the CGRP antagonist 1- [N 2 - [3,5-dibromo-N - [[4- (3,4-dihydro-2 (1 H) -oxoquinazolin-3-yl] -1-piperidinyl] carbonyl] -D-tyrosyl] -L-lysyl] -4- (4-pyrindinyl) piperazine, process for its preparation and its use as inhalant |
GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
CN101098678A (en) | 2004-04-23 | 2008-01-02 | 锡德克斯公司 | Dpi formulation containing sulfoalkyl ether cyclodextrin |
EP2540696B1 (en) | 2005-02-24 | 2020-01-01 | Diffusion Pharmaceuticals LLC | Trans carotenoids, formulation and uses |
RU2007137121A (en) * | 2005-03-09 | 2009-04-20 | Оно Фармасьютикал Ко., Лтд. (Jp) | PARTICLE AND PREPARATION CONTAINING THE SPECIFIED PARTICLE |
US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
EP2581078B1 (en) | 2005-10-26 | 2014-12-10 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
US20080035143A1 (en) * | 2006-08-14 | 2008-02-14 | Sievers Robert E | Human-powered dry powder inhaler and dry powder inhaler compositions |
US20100093875A1 (en) * | 2006-10-25 | 2010-04-15 | Dainippon Sumitomo Pharma Co., Ltd. | Granular preparation prevented from caking |
EP1925295A1 (en) * | 2006-11-22 | 2008-05-28 | Boehringer Ingelheim Pharma GmbH & Co. KG | Stable powder formulation containing a new antichinolinergic agent |
MX2009010988A (en) | 2007-04-13 | 2010-03-15 | Diffusion Pharmaceuticals Llc | Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease. |
JP2011502125A (en) | 2007-10-31 | 2011-01-20 | ディフュージョン・ファーマシューティカルズ・エルエルシー | A new class of treatments that promote small molecule diffusion |
ES2661215T3 (en) | 2009-05-20 | 2018-03-28 | Aeras | Viral compositions; immunogens; spray dried; stable |
CA2765697C (en) | 2009-06-22 | 2019-11-12 | Diffusion Pharmaceuticals Llc | Diffusion enhancing compounds and their use alone or with thrombolytics |
AU2011262361A1 (en) | 2010-06-02 | 2013-01-10 | Diffusion Pharmaceuticals Llc | Oral formulations of bipolar trans carotenoids |
IN2014MN02359A (en) * | 2012-05-03 | 2015-08-14 | Janssen R & D Ireland | |
WO2014074797A1 (en) * | 2012-11-09 | 2014-05-15 | Civitas Therapeutics, Inc. | Ultra low density pulmonary powders |
US20180043585A9 (en) * | 2013-09-20 | 2018-02-15 | Virginia Commonwealth University | Delivery of particles using hygroscopic excipients |
MX2017005692A (en) | 2014-10-31 | 2017-08-07 | Glaxosmithkline Ip Dev Ltd | Powder formulation. |
CN115089569A (en) | 2016-03-24 | 2022-09-23 | 扩散药品有限公司 | Use of bipolar trans carotenoids in conjunction with chemotherapy and radiation therapy for the treatment of cancer |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3155573A (en) * | 1958-05-06 | 1964-11-03 | Benger Lab Ltd | Inhalant composition and method of making same |
EP0611567B1 (en) * | 1992-06-12 | 2002-08-28 | Teijin Limited | Ultrafine powder for inhalation and production thereof |
US6524557B1 (en) * | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
PT954282E (en) * | 1997-01-16 | 2005-06-30 | Massachusetts Inst Technology | PREPARATION OF PARTICLES FOR INHALATION |
US6086376A (en) * | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
-
1999
- 1999-09-09 MA MA25762A patent/MA25590A1/en unknown
- 1999-09-13 AR ARP990104587A patent/AR022090A1/en unknown
- 1999-09-13 BR BR9913722-4A patent/BR9913722A/en not_active IP Right Cessation
- 1999-09-13 TR TR2001/01182T patent/TR200101182T2/en unknown
- 1999-09-13 PE PE1999000925A patent/PE20001061A1/en not_active Application Discontinuation
- 1999-09-13 GE GEAP19995857A patent/GEP20043257B/en unknown
- 1999-09-13 OA OA1200100063A patent/OA11781A/en unknown
- 1999-09-13 MY MYPI99003947A patent/MY129282A/en unknown
- 1999-09-13 CA CA002343920A patent/CA2343920A1/en not_active Abandoned
- 1999-09-13 CN CN99810871A patent/CN1317977A/en active Pending
- 1999-09-13 ZA ZA200101995A patent/ZA200101995B/en unknown
- 1999-09-13 EE EEP200100151A patent/EE200100151A/en unknown
- 1999-09-13 AU AU60397/99A patent/AU753014B2/en not_active Ceased
- 1999-09-13 UA UA2001031707A patent/UA76085C2/en unknown
- 1999-09-13 HU HU0103837A patent/HUP0103837A3/en unknown
- 1999-09-13 ID IDW20010582A patent/ID28845A/en unknown
- 1999-09-13 IL IL14156299A patent/IL141562A0/en not_active IP Right Cessation
- 1999-09-13 CZ CZ2001829A patent/CZ2001829A3/en unknown
- 1999-09-13 AP APAP/P/2001/002093A patent/AP1374A/en active
- 1999-09-13 NZ NZ510168A patent/NZ510168A/en unknown
- 1999-09-13 EA EA200100300A patent/EA003476B1/en active IP Right Revival
- 1999-09-13 JP JP2000569846A patent/JP2002524535A/en not_active Withdrawn
- 1999-09-13 SK SK344-2001A patent/SK3442001A3/en unknown
- 1999-09-13 HN HN1999000159A patent/HN1999000159A/en unknown
- 1999-09-13 YU YU24201A patent/YU24201A/en unknown
- 1999-09-13 KR KR1020017003208A patent/KR20010075063A/en not_active Application Discontinuation
- 1999-09-13 PL PL99346768A patent/PL195574B1/en not_active IP Right Cessation
- 1999-09-13 WO PCT/US1999/021109 patent/WO2000015262A1/en not_active Application Discontinuation
- 1999-09-13 EP EP99969035A patent/EP1117442A1/en not_active Withdrawn
- 1999-09-13 TW TW088115876A patent/TWI226248B/en not_active IP Right Cessation
- 1999-09-13 DZ DZ990192A patent/DZ2892A1/en active
- 1999-09-14 CO CO99058265A patent/CO5130023A1/en unknown
- 1999-09-14 GT GT199900156A patent/GT199900156A/en unknown
- 1999-09-14 PA PA19998481901A patent/PA8481901A1/en unknown
- 1999-09-14 UY UY25711A patent/UY25711A1/en not_active Application Discontinuation
- 1999-09-14 TN TNTNSN99173A patent/TNSN99173A1/en unknown
- 1999-10-31 SA SA99200718A patent/SA99200718B1/en unknown
-
2001
- 2001-02-21 IL IL141562A patent/IL141562A/en unknown
- 2001-03-05 IS IS5878A patent/IS5878A/en unknown
- 2001-03-13 NO NO20011251A patent/NO20011251L/en not_active Application Discontinuation
- 2001-03-14 HR HR20010189A patent/HRP20010189A2/en not_active Application Discontinuation
- 2001-03-14 LT LT2001021A patent/LT4897B/en not_active IP Right Cessation
- 2001-03-14 LV LV010041A patent/LV12658B/en unknown
- 2001-04-10 BG BG105430A patent/BG105430A/en unknown
-
2002
- 2002-03-06 HK HK02101738.3A patent/HK1042231A1/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title | ||
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |
|
NF4A | Restoration of lapsed right to a eurasian patent |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |