GT199900156A - ADMINISTRATION OF ACTIVE AGENT IN DRY POWDER. - Google Patents
ADMINISTRATION OF ACTIVE AGENT IN DRY POWDER.Info
- Publication number
- GT199900156A GT199900156A GT199900156A GT199900156A GT199900156A GT 199900156 A GT199900156 A GT 199900156A GT 199900156 A GT199900156 A GT 199900156A GT 199900156 A GT199900156 A GT 199900156A GT 199900156 A GT199900156 A GT 199900156A
- Authority
- GT
- Guatemala
- Prior art keywords
- active agent
- dry powder
- administration
- hygroscopic
- development
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
LA PRESENTE INVENCIÒN SE RELACIONA CON LA ADMINISTRACIÒN MEJORADA DE UNA FORMULACIÒN DE AGENTE ACTIVO EN POLVO SECO HACIA LAS PROFUNDIDADES DEL PULMÒN. MÀS ESPECÌFICAMENTE, LA INVENCIÒN SE REFIERE A PARTÌCULAS DE POLVO SECO AEROSOLIZABLES QUE, AL SER INHALADAS, SON RESISTENTES AL DESARROLLO HIGROSCÒPICO. ESTA CARACTERÌSTICA DEL POLVO (SU RESISTENCIA AL DESARROLLO HIGROSCÒPICO) PERMITE QUE UNA MAYOR PROPORCIÒN DE LAS PARTÌCULAS INHALADAS LLEGUE A LA PROFUNDIDAD DEL PULMÒN, AUMENTANDO ASÌ LA BIODISPONIBLIDAD DE UN AGENTE ACTIVO ADMINISTRADO AL PULMÒN.THIS INVENTION IS RELATED TO THE IMPROVED ADMINISTRATION OF A DRY POWDER ACTIVE AGENT FORMULATION TO THE DEPTHS OF THE PULMÒN. MORE SPECIFICALLY, THE INVENTION REFERS TO AEROSOLIZABLE DRY POWDER PARTICLES WHICH, WHEN INHALED, ARE RESISTANT TO HYGROSCOPIC DEVELOPMENT. THIS CHARACTERISTICS OF THE POWDER (ITS RESISTANCE TO HYGROSCOPIC DEVELOPMENT) ALLOWS THAT A GREATER PROPORTION OF THE INHALED PARTICLES COMES TO THE DEPTH OF THE PULM, thus increasing the bioavailability of an active agent administered to the lung.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10016398P | 1998-09-14 | 1998-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT199900156A true GT199900156A (en) | 2001-03-07 |
Family
ID=22278404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT199900156A GT199900156A (en) | 1998-09-14 | 1999-09-14 | ADMINISTRATION OF ACTIVE AGENT IN DRY POWDER. |
Country Status (44)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1185248B1 (en) | 1999-06-09 | 2012-05-02 | Robert E. Sievers | Supercritical fluid-assisted nebulization and bubble drying |
| US6475468B2 (en) * | 2001-02-15 | 2002-11-05 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
| JP2005503425A (en) * | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | Delivery of drug ester by the prescribed inhalation route |
| EG24184A (en) | 2001-06-15 | 2008-10-08 | Otsuka Pharma Co Ltd | Dry powder inhalation system for transpulmonary |
| US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| IL163685A0 (en) | 2002-02-25 | 2005-12-18 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| WO2004004798A2 (en) * | 2002-07-03 | 2004-01-15 | The Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
| ATE353633T1 (en) * | 2002-12-19 | 2007-03-15 | Pharmacia Corp | NON-HYGROSCOPIC FORMULATION CONTAINING A HYGROSCOPIC ACTIVE INGREDIENT |
| DE10338403A1 (en) * | 2003-08-18 | 2005-03-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder formulation containing the CGRP antagonist 1- [N 2 - [3,5-dibromo-N - [[4- (3,4-dihydro-2 (1 H) -oxoquinazolin-3-yl] -1-piperidinyl] carbonyl] -D-tyrosyl] -L-lysyl] -4- (4-pyrindinyl) piperazine, process for its preparation and its use as inhalant |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| DK3520779T3 (en) | 2004-04-23 | 2022-03-21 | Cydex Pharmaceuticals Inc | DPI formulation containing sulfoalkyl ether cyclodextrin |
| KR101315904B1 (en) | 2005-02-24 | 2013-10-08 | 디퓨젼 파마슈티컬즈 엘엘씨 | Trans Carotenoids, Their Synthesis, Formulation and Uses |
| JPWO2006095788A1 (en) * | 2005-03-09 | 2008-08-14 | 小野薬品工業株式会社 | Particles and formulations containing the particles |
| US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| BRPI0520654B8 (en) | 2005-10-26 | 2021-05-25 | Cydex Pharmaceuticals Inc | sulfoalkyl ether cyclodextrin compositions and process for preparing the same |
| WO2008021451A2 (en) * | 2006-08-14 | 2008-02-21 | Aktiv-Dry Llc | Human-powered dry powder inhaler and dry powder inhaler compositions |
| KR20090081407A (en) * | 2006-10-25 | 2009-07-28 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | Granular preparation prevented from caking |
| EP1925295A1 (en) * | 2006-11-22 | 2008-05-28 | Boehringer Ingelheim Pharma GmbH & Co. KG | Stable powder formulation containing a new antichinolinergic agent |
| JP2010524855A (en) | 2007-04-13 | 2010-07-22 | ディフュージョン・ファーマシューティカルズ・エルエルシー | Use of bipolar trans carotenoids as and in the pretreatment of peripheral vascular disease |
| MX2010004803A (en) | 2007-10-31 | 2010-09-09 | Diffusion Pharmaceuticals Llc | A new class of therapeutics that enhance small molecule diffusion. |
| PT2432502T (en) | 2009-05-20 | 2018-03-08 | Aeras | Stable, spray dried, immunogenic, viral compositions |
| US10130689B2 (en) | 2009-06-22 | 2018-11-20 | Diffusion Pharmaceuticals Llc | Diffusion enhancing compounds and their use alone or with thrombolytics |
| CA2801292C (en) | 2010-06-02 | 2019-01-22 | Diffusion Pharmaceuticals Llc | Oral formulations of bipolar trans carotenoids |
| MX2014013256A (en) | 2012-05-03 | 2015-01-16 | Janssen R & D Ireland | Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections. |
| BR112015010601B1 (en) * | 2012-11-09 | 2022-07-19 | Civitas Therapeutics, Inc. | PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOSITION |
| US20180043585A9 (en) * | 2013-09-20 | 2018-02-15 | Virginia Commonwealth University | Delivery of particles using hygroscopic excipients |
| US10806770B2 (en) | 2014-10-31 | 2020-10-20 | Monash University | Powder formulation |
| CN109152839A (en) | 2016-03-24 | 2019-01-04 | 扩散药品有限公司 | Purposes of the bipolarity trans-carotenoid together with chemotherapy and radiotherapy in treating cancer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3155573A (en) * | 1958-05-06 | 1964-11-03 | Benger Lab Ltd | Inhalant composition and method of making same |
| DE69332240T2 (en) * | 1992-06-12 | 2003-04-10 | Teijin Ltd | ULTRA FINE POWDER FOR INHALATION AND PRODUCTION |
| US6524557B1 (en) * | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| EP0954282B1 (en) * | 1997-01-16 | 2005-01-19 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US6086376A (en) * | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
-
1999
- 1999-09-09 MA MA25762A patent/MA25590A1/en unknown
- 1999-09-13 KR KR1020017003208A patent/KR20010075063A/en not_active Application Discontinuation
- 1999-09-13 AR ARP990104587A patent/AR022090A1/en unknown
- 1999-09-13 JP JP2000569846A patent/JP2002524535A/en not_active Withdrawn
- 1999-09-13 PL PL99346768A patent/PL195574B1/en not_active IP Right Cessation
- 1999-09-13 CN CN99810871A patent/CN1317977A/en active Pending
- 1999-09-13 TR TR2001/01182T patent/TR200101182T2/en unknown
- 1999-09-13 SK SK344-2001A patent/SK3442001A3/en unknown
- 1999-09-13 AP APAP/P/2001/002093A patent/AP1374A/en active
- 1999-09-13 ZA ZA200101995A patent/ZA200101995B/en unknown
- 1999-09-13 EA EA200100300A patent/EA003476B1/en active IP Right Revival
- 1999-09-13 BR BR9913722-4A patent/BR9913722A/en not_active IP Right Cessation
- 1999-09-13 CZ CZ2001829A patent/CZ2001829A3/en unknown
- 1999-09-13 NZ NZ510168A patent/NZ510168A/en unknown
- 1999-09-13 AU AU60397/99A patent/AU753014B2/en not_active Ceased
- 1999-09-13 DZ DZ990192A patent/DZ2892A1/en active
- 1999-09-13 OA OA1200100063A patent/OA11781A/en unknown
- 1999-09-13 HU HU0103837A patent/HUP0103837A3/en unknown
- 1999-09-13 IL IL14156299A patent/IL141562A0/en not_active IP Right Cessation
- 1999-09-13 WO PCT/US1999/021109 patent/WO2000015262A1/en not_active Application Discontinuation
- 1999-09-13 UA UA2001031707A patent/UA76085C2/en unknown
- 1999-09-13 EP EP99969035A patent/EP1117442A1/en not_active Withdrawn
- 1999-09-13 TW TW088115876A patent/TWI226248B/en not_active IP Right Cessation
- 1999-09-13 ID IDW20010582A patent/ID28845A/en unknown
- 1999-09-13 MY MYPI99003947A patent/MY129282A/en unknown
- 1999-09-13 YU YU24201A patent/YU24201A/en unknown
- 1999-09-13 CA CA002343920A patent/CA2343920A1/en not_active Abandoned
- 1999-09-13 HN HN1999000159A patent/HN1999000159A/en unknown
- 1999-09-13 EE EEP200100151A patent/EE200100151A/en unknown
- 1999-09-13 GE GEAP19995857A patent/GEP20043257B/en unknown
- 1999-09-13 PE PE1999000925A patent/PE20001061A1/en not_active Application Discontinuation
- 1999-09-14 GT GT199900156A patent/GT199900156A/en unknown
- 1999-09-14 PA PA19998481901A patent/PA8481901A1/en unknown
- 1999-09-14 CO CO99058265A patent/CO5130023A1/en unknown
- 1999-09-14 UY UY25711A patent/UY25711A1/en not_active Application Discontinuation
- 1999-09-14 TN TNTNSN99173A patent/TNSN99173A1/en unknown
- 1999-10-31 SA SA99200718A patent/SA99200718B1/en unknown
-
2001
- 2001-02-21 IL IL141562A patent/IL141562A/en unknown
- 2001-03-05 IS IS5878A patent/IS5878A/en unknown
- 2001-03-13 NO NO20011251A patent/NO20011251L/en not_active Application Discontinuation
- 2001-03-14 LT LT2001021A patent/LT4897B/en not_active IP Right Cessation
- 2001-03-14 HR HR20010189A patent/HRP20010189A2/en not_active Application Discontinuation
- 2001-03-14 LV LV010041A patent/LV12658B/en unknown
- 2001-04-10 BG BG105430A patent/BG105430A/en unknown
-
2002
- 2002-03-06 HK HK02101738.3A patent/HK1042231A1/en unknown
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