TR200002376T2 - 5-İkameli pirimidin-2-iloksi karbon asidi türevleri/imalatları/endotelin-antagonistleri olarak kullanımları - Google Patents

5-İkameli pirimidin-2-iloksi karbon asidi türevleri/imalatları/endotelin-antagonistleri olarak kullanımları

Info

Publication number
TR200002376T2
TR200002376T2 TR2000/02376T TR200002376T TR200002376T2 TR 200002376 T2 TR200002376 T2 TR 200002376T2 TR 2000/02376 T TR2000/02376 T TR 2000/02376T TR 200002376 T TR200002376 T TR 200002376T TR 200002376 T2 TR200002376 T2 TR 200002376T2
Authority
TR
Turkey
Prior art keywords
alkyl
heteroaromate
naphthyl
ring
endothelin
Prior art date
Application number
TR2000/02376T
Other languages
English (en)
Inventor
Amberg Wilhelm
Jansen Rolf
Kling Andreas
Klinge Dagmar
Riechers Hartmut
Hergenr�Der Stefan
Raschack Manfred
Unger Liliane
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of TR200002376T2 publication Critical patent/TR200002376T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Formül (I)' in karbonasidi türevlerinin ikame maddeleri: R1 Tetrazol veya bir grup (I), R bir OR7 (2), (3), artigi, pirrolil,, pirazolil, imidazolil ve triyazolil gibi bir nitrojen atomu üzerinden baglanmis olan 5 halkali bir heteroaromat; R2, R3 hidrojen, hidroksi, NH2, NH(C1-C4-alkil), N(C1-C4-alkil)2, halojen, C1-C4-alkil, C2-C4-alkenil, C2-C4-alkinil, C1-C4-hidroksialkil, C1-C4-halojenalkil, C1-C4-alkoksi, C1-C4-halojenalkoksi veya C1-C4-alkiltiyo; x halojen, C1-C4-halojenalkil, hidroksi; R4 ve R5 fenil veya naftil, C3-C7-sikoalkil, orto konumlu dogrudan bir bag, metilen, etilen veya etenilen grubu, bir oksijen veya kükürt atomu veya bir SO2-, NH- veya N-alkil grubu üzerinden birbirine baglanmis olan veya naftil, bes-alti halkali bir heteroaromat; R6 hidrojen, fenil veya naftil, bes-alti halkali bir heteroaromat, C1-C8-alkil, C3-C6-alkenil, C3-C6-alkinil veya C3-C8-sikloalkil; Z kükürt, oksijen veya basit bir bag ayrica fizyolojik hazmedilen tuzlar ve enansiyomer'den DEVAMI VAR...
TR2000/02376T 1998-02-17 1999-02-05 5-İkameli pirimidin-2-iloksi karbon asidi türevleri/imalatları/endotelin-antagonistleri olarak kullanımları TR200002376T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19806438A DE19806438A1 (de) 1998-02-17 1998-02-17 Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
TR200002376T2 true TR200002376T2 (tr) 2000-12-21

Family

ID=7857948

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02376T TR200002376T2 (tr) 1998-02-17 1999-02-05 5-İkameli pirimidin-2-iloksi karbon asidi türevleri/imalatları/endotelin-antagonistleri olarak kullanımları

Country Status (20)

Country Link
EP (1) EP1066268A1 (tr)
JP (1) JP2002503726A (tr)
KR (1) KR20010086247A (tr)
CN (1) CN1291190A (tr)
AR (1) AR014960A1 (tr)
AU (1) AU3027199A (tr)
BG (1) BG104577A (tr)
BR (1) BR9907911A (tr)
CA (1) CA2321182A1 (tr)
DE (1) DE19806438A1 (tr)
HR (1) HRP20000602A2 (tr)
HU (1) HUP0100957A3 (tr)
IL (1) IL137038A0 (tr)
NO (1) NO20004075D0 (tr)
PL (1) PL342311A1 (tr)
SK (1) SK11512000A3 (tr)
TR (1) TR200002376T2 (tr)
TW (1) TW579376B (tr)
WO (1) WO1999042453A1 (tr)
ZA (1) ZA991214B (tr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924892A1 (de) * 1999-06-01 2000-12-07 Basf Ag Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten
US8217155B2 (en) 2007-07-31 2012-07-10 Gilead Colorado, Inc. Metabolites and derivatives of ambrisentan
JP5749017B2 (ja) 2008-01-22 2015-07-15 ダウ アグロサイエンシィズ エルエルシー ５−フルオロピリミジン誘導体
EP2317851B1 (en) * 2008-08-01 2014-01-15 Dow AgroSciences LLC Use of 5-fluorocytosine as a fungicide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4411225A1 (de) * 1994-03-31 1995-10-05 Basf Ag Verwendung von Carbonsäurederivaten als Arzneimittel
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19614534A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19614533A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung
CN1247533A (zh) * 1996-12-18 2000-03-15 Basf公司 杂环羧酸衍生物,它们的制备方法和它们作为内皮素(endothelin)受体拮抗剂的用途
DE19726146A1 (de) * 1997-06-19 1998-12-24 Basf Ag Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten
BR9814951A (pt) * 1997-10-31 2000-10-03 Basf Ag Derivado de ácido carboxìlico, uso do mesmo, preparação de medicamento para o uso oral, parenteral, combinação, uso de compostos, fragmento estrutural, uso do mesmo, antagonista de receptor de endotelina, e, composto

Also Published As

Publication number Publication date
CN1291190A (zh) 2001-04-11
AR014960A1 (es) 2001-04-11
JP2002503726A (ja) 2002-02-05
AU3027199A (en) 1999-09-06
TW579376B (en) 2004-03-11
HUP0100957A3 (en) 2002-03-28
PL342311A1 (en) 2001-06-04
HUP0100957A2 (hu) 2002-02-28
BR9907911A (pt) 2000-10-24
IL137038A0 (en) 2001-06-14
ZA991214B (en) 2000-08-16
HRP20000602A2 (en) 2001-06-30
WO1999042453A1 (de) 1999-08-26
CA2321182A1 (en) 1999-08-26
NO20004075L (no) 2000-08-15
EP1066268A1 (de) 2001-01-10
KR20010086247A (ko) 2001-09-10
DE19806438A1 (de) 1999-08-19
NO20004075D0 (no) 2000-08-15
SK11512000A3 (sk) 2001-04-09
BG104577A (bg) 2001-03-30

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