TR200001669T2 - Piperidin türevleri. - Google Patents

Piperidin türevleri.

Info

Publication number
TR200001669T2
TR200001669T2 TR2000/01669T TR200001669T TR200001669T2 TR 200001669 T2 TR200001669 T2 TR 200001669T2 TR 2000/01669 T TR2000/01669 T TR 2000/01669T TR 200001669 T TR200001669 T TR 200001669T TR 200001669 T2 TR200001669 T2 TR 200001669T2
Authority
TR
Turkey
Prior art keywords
disorders
compounds
formula
memory
piperidine derivatives
Prior art date
Application number
TR2000/01669T
Other languages
English (en)
Inventor
Adam Geo
Cesura Andera
Galley Guido
Jenck Fran�Ois
R�Ver Stephan
Wichmann J�Rgen
Original Assignee
H.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Hoffmann-La Roche Ag filed Critical H.Hoffmann-La Roche Ag
Publication of TR200001669T2 publication Critical patent/TR200001669T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Bu bulus formül (I-1)'i havi bilesikler ve bunlarin farmasötik yönden kabul edilebilir asit adisyon tuzlariyla ile ilgilidir. Bu bulusun bilesikleri OFQ reseptörünün antagonistleridir. Dolayisiyla, hafiza ve dikkat yetersizligi, psikiyatrik, nörolojik ve fizyolojik bozukliklar, özellikle de /ancak bunlarla kisitli olmamak üzere) anksiyete ve strese iliskin bozukluklar, depresyon, Alzheimer hastaligi sebebiyle hafiza kaybi ve sair dementiyalar, epilesi ve konvülsiyonlar, akut ve/veya kronik sanci/agri durumlari, uyusturucu maddenin birakilmasindan sonraki semptomlar, su dengesinin kontrolu, Na+ ekskresyonu ve kan basinci bozukluklari ve oburluk gibi metabolik bozukluklarin tedavisinde faydali olacaklardir. Formül.
TR2000/01669T 1997-12-11 1998-12-03 Piperidin türevleri. TR200001669T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97121844 1997-12-11

Publications (1)

Publication Number Publication Date
TR200001669T2 true TR200001669T2 (tr) 2001-01-22

Family

ID=8227781

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01669T TR200001669T2 (tr) 1997-12-11 1998-12-03 Piperidin türevleri.

Country Status (16)

Country Link
US (1) US6166209A (tr)
EP (1) EP1037892B1 (tr)
JP (1) JP3453121B2 (tr)
KR (1) KR100369689B1 (tr)
CN (1) CN1112365C (tr)
AR (1) AR016431A1 (tr)
AT (1) ATE278695T1 (tr)
AU (1) AU744192B2 (tr)
BR (1) BR9813543A (tr)
CA (1) CA2310458C (tr)
DE (1) DE69826891T2 (tr)
ES (1) ES2229557T3 (tr)
PT (1) PT1037892E (tr)
TR (1) TR200001669T2 (tr)
WO (1) WO1999029696A1 (tr)
ZA (1) ZA9811345B (tr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6462053B1 (en) 1999-08-20 2002-10-08 Banyu Pharmaceutical Co., Ltd. Spiro compounds
TWI279402B (en) 1999-08-20 2007-04-21 Banyu Pharma Co Ltd Spiro compounds having NPY antagonistic activities and agents containing the same
US6803372B2 (en) 1999-08-20 2004-10-12 Banyu Pharmaceutical Co., Ltd. Spiro compounds
WO2001039723A2 (en) 1999-12-06 2001-06-07 Euro-Celtique, S.A. Triazospiro compounds having nociceptin receptor affinity
EP1244437A4 (en) 1999-12-06 2005-02-09 Euro Celtique Sa TERTIARY AMINO COMPOUNDS HAVING AFFINITY FOR OPIOID RECEPTOR
DE60022226D1 (de) 1999-12-06 2005-09-29 Euro Celtique Sa Benzimidazolverbindungen die nociceptinrezeptoraffinität haben
EP1256575B1 (en) * 2000-02-18 2005-08-17 Meiji Seika Kaisha Ltd. Phenoxyalkylamine derivatives useful as opioid delta receptor agonists
MXPA03009604A (es) 2001-04-18 2004-04-02 Euro Celtique Sa Compuestos de espiropirazol.
RU2268883C2 (ru) 2001-04-18 2006-01-27 Эро-Селтик, С.А. Аналоги ноницептина и фармацевтическая композиция на их основе
EP1385518B1 (en) 2001-04-18 2008-08-06 Euro-Celtique S.A. Benzimidazolone compounds
SI1598340T1 (sl) 2001-04-18 2009-08-31 Euro Celtique Sa Derivati 1-(4-piperidinil)-1,3-dihidro-2H-benzoksazol-2-ona in sorodne spojine kot analogi nociceptina in ligandi ORL1 za zdravljenje bolečine
DK1385514T5 (da) * 2001-04-18 2009-03-09 Euro Celtique Sa Spiroinden- og spiroindanforbindelser
WO2002088089A1 (fr) * 2001-04-19 2002-11-07 Banyu Pharmaceutical Co., Ltd. Derives de spiropiperidine, antagonistes du recepteur de nociceptine les contenant en tant qu'ingredient actif et compositions medicinales
WO2002094825A1 (fr) * 2001-05-22 2002-11-28 Banyu Pharmaceutical Co., Ltd. Nouveau derive de spiropiperidine
US20030078278A1 (en) * 2001-06-26 2003-04-24 Pfizer Inc. Spiropiperidine compounds as ligands for ORL-1 receptor
PT1491212E (pt) 2002-03-29 2012-11-16 Mitsubishi Tanabe Pharma Corp Medicamento para distúrbios de sono
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
WO2005085228A1 (ja) * 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd. シクロアルカノピリジン誘導体
BRPI0518859A2 (pt) * 2004-12-09 2008-12-09 Virochem Pharma Inc compostos de espirotropano e mÉtodos para a modulaÇço de atividade de receptor de quimiocina
EP1824853A4 (en) 2004-12-09 2010-06-09 Virochem Pharma Inc NEW SPIROTROPAN COMPOUNDS AND METHOD FOR MODULATING THE ACTIVITY OF THE CHEMOKIN RECEPTOR
JP2008543826A (ja) * 2005-06-17 2008-12-04 ファイザー株式会社 ＯＲＬ１−受容体アンタゴニストとしてのα−（アリール−またはヘテロアリール−メチル）−β−ピペリジノプロパン酸化合物
US8193208B2 (en) * 2005-09-09 2012-06-05 Purdue Pharma L.P. Fused and spirocycle compounds and the use thereof
WO2007085357A1 (en) * 2006-01-30 2007-08-02 Euro-Celtique S.A. Cyclourea compounds as calcium channel blockers
BRPI0720004A2 (pt) 2006-12-07 2013-12-17 Hoffmann La Roche Derivados de espiro-piperidina como antagonista de receptor v1a
RU2009123133A (ru) 2006-12-22 2011-01-27 Ф.Хоффманн-Ля Рош Аг (Ch) Производные спиро-пиперидина
US7501432B2 (en) 2006-12-22 2009-03-10 Hoffman-La Roche Inc. Spiro-piperidine derivatives
US8728275B2 (en) 2012-07-27 2014-05-20 Ecolab Usa Inc. Glycerol-based polymers for reducing deposition of organic contaminants in papermaking processes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962259A (en) * 1973-12-12 1976-06-08 American Hoechst Corporation 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
CA2226058C (en) * 1997-01-30 2008-01-29 F. Hoffmann-La Roche Ag 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives

Also Published As

Publication number Publication date
CN1112365C (zh) 2003-06-25
CN1281459A (zh) 2001-01-24
CA2310458A1 (en) 1999-06-17
PT1037892E (pt) 2005-01-31
KR20010032958A (ko) 2001-04-25
AU744192B2 (en) 2002-02-21
CA2310458C (en) 2008-11-04
EP1037892B1 (en) 2004-10-06
WO1999029696A1 (en) 1999-06-17
DE69826891D1 (de) 2004-11-11
EP1037892A1 (en) 2000-09-27
ATE278695T1 (de) 2004-10-15
BR9813543A (pt) 2000-10-10
JP3453121B2 (ja) 2003-10-06
US6166209A (en) 2000-12-26
KR100369689B1 (ko) 2003-01-30
ES2229557T3 (es) 2005-04-16
DE69826891T2 (de) 2005-11-24
ZA9811345B (en) 1999-06-11
AR016431A1 (es) 2001-07-04
AU2157899A (en) 1999-06-28
JP2001525414A (ja) 2001-12-11

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