TR199902816T2 - Gelistirilmis bir oral emilmesi ve biyolojik yararlanimi olan bir HIV proteaz inhibitörünün sülfat tuzu. - Google Patents

Gelistirilmis bir oral emilmesi ve biyolojik yararlanimi olan bir HIV proteaz inhibitörünün sülfat tuzu.

Info

Publication number
TR199902816T2
TR199902816T2 TR1999/02816T TR9902816T TR199902816T2 TR 199902816 T2 TR199902816 T2 TR 199902816T2 TR 1999/02816 T TR1999/02816 T TR 1999/02816T TR 9902816 T TR9902816 T TR 9902816T TR 199902816 T2 TR199902816 T2 TR 199902816T2
Authority
TR
Turkey
Prior art keywords
protease inhibitor
hiv protease
sulfate salt
bioavailability
oral absorption
Prior art date
Application number
TR1999/02816T
Other languages
English (en)
Inventor
Askin David
Scott Hoerrner R.
M. Purick Robert
Reider Paul
J. Varsolona Richard
P. Volante Ralph
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9714320.0A external-priority patent/GB9714320D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of TR199902816T2 publication Critical patent/TR199902816T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Bu bulus bir HIV proteaz inhibitörünün bir sülfat tuzu, bilesik A, ile ilgilidir, ki bu eriskinlerde ve çocuklarda, AIDS,ARC veya HIV enfeksiyonunun tedavisinde kullanislidir. Daha özel olarak, bulus, hayvan modellerinde, daha fazla oral emilme ve biyolojik yararlanim ile sonuçlanan, seyreltik HCI (gastrik asit) çözeltisi içinde büyük ölçüde gelistirilmis çözünürlügü olan HIV proteaz inhibitörünün bir sülfat tuzunu, bilesik A, yi saglar. Özel HIV proteaz inhibitör bilesiklerinin sülfat tuzlarinin yapilmasi için yöntemler de tarif edilmistir.
TR1999/02816T 1997-05-29 1998-05-26 Gelistirilmis bir oral emilmesi ve biyolojik yararlanimi olan bir HIV proteaz inhibitörünün sülfat tuzu. TR199902816T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4795097P 1997-05-29 1997-05-29
GBGB9714320.0A GB9714320D0 (en) 1997-07-07 1997-07-07 Hiv protease inhibitor

Publications (1)

Publication Number Publication Date
TR199902816T2 true TR199902816T2 (tr) 2000-02-21

Family

ID=26311845

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/02816T TR199902816T2 (tr) 1997-05-29 1998-05-26 Gelistirilmis bir oral emilmesi ve biyolojik yararlanimi olan bir HIV proteaz inhibitörünün sülfat tuzu.

Country Status (22)

Country Link
EP (1) EP0986554A1 (tr)
JP (1) JP3267632B2 (tr)
KR (1) KR20010013042A (tr)
CN (1) CN1257497A (tr)
AU (1) AU730245B2 (tr)
BG (1) BG103923A (tr)
BR (1) BR9809498A (tr)
CA (1) CA2291086A1 (tr)
EA (1) EA199901095A1 (tr)
EE (1) EE9900543A (tr)
HR (1) HRP980283A2 (tr)
HU (1) HUP0004621A3 (tr)
ID (1) ID23858A (tr)
IL (1) IL132779A0 (tr)
IS (1) IS5240A (tr)
NO (1) NO995822L (tr)
PE (1) PE75099A1 (tr)
PL (1) PL336847A1 (tr)
SK (1) SK163299A3 (tr)
TR (1) TR199902816T2 (tr)
TW (1) TW438799B (tr)
WO (1) WO1998054178A1 (tr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU777824B2 (en) * 1999-11-24 2004-11-04 Merck Sharp & Dohme Corp. Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1- piperazinepentanamides as HIV protease inhibitors
AU2001290743A1 (en) * 2000-09-14 2002-03-26 Ortho-Mcneil Pharmaceutical, Inc. Solid salt forms of n-(2-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)ethyl)-2-oxo-1-piperidineacetamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995016688A1 (en) * 1993-12-15 1995-06-22 Merck & Co., Inc. Hiv protease inhibitors

Also Published As

Publication number Publication date
AU730245B2 (en) 2001-03-01
HRP980283A2 (en) 1999-08-31
IS5240A (is) 1999-11-09
AU7595998A (en) 1998-12-30
BR9809498A (pt) 2000-06-20
IL132779A0 (en) 2001-03-19
TW438799B (en) 2001-06-07
NO995822D0 (no) 1999-11-26
BG103923A (en) 2000-06-30
KR20010013042A (ko) 2001-02-26
EP0986554A1 (en) 2000-03-22
EA199901095A1 (ru) 2000-08-28
SK163299A3 (en) 2000-07-11
JP2000513747A (ja) 2000-10-17
HUP0004621A3 (en) 2002-04-29
PE75099A1 (es) 1999-08-11
EE9900543A (et) 2000-06-15
CA2291086A1 (en) 1998-12-03
WO1998054178A1 (en) 1998-12-03
NO995822L (no) 2000-01-28
PL336847A1 (en) 2000-07-17
CN1257497A (zh) 2000-06-21
HUP0004621A2 (hu) 2002-03-28
JP3267632B2 (ja) 2002-03-18
ID23858A (id) 2000-05-25

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