PE75099A1 - Inhibidor de proteasa de vih - Google Patents

Inhibidor de proteasa de vih

Info

Publication number
PE75099A1
PE75099A1 PE1998000432A PE00043298A PE75099A1 PE 75099 A1 PE75099 A1 PE 75099A1 PE 1998000432 A PE1998000432 A PE 1998000432A PE 00043298 A PE00043298 A PE 00043298A PE 75099 A1 PE75099 A1 PE 75099A1
Authority
PE
Peru
Prior art keywords
hiv protease
crystalline
refers
compound
protease inhibitor
Prior art date
Application number
PE1998000432A
Other languages
English (en)
Inventor
Richard J Varsolona
David Askin
Robert M Purick
Ralph P Volante
Paul Reider
R Scott Hoerrner
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9714320.0A external-priority patent/GB9714320D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PE75099A1 publication Critical patent/PE75099A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I), CRISTALINO O SU MONOETANOLATO, HEMIETANOLATO, SESQUIETANOLATO CRISTALINO; CARACTERIZADO POR SU CURVA DE BARRIDO DIFERENCIAL DE CALORIMETRIA (DSC); PATRON DE DIFRACCION DEL POLVO A LOS RAYOS X. TAMBIEN SE REFIERE AL PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I EN FORMA DE SAL DE SULFATO INHIBE LA PROTEASA DEL VIH POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO O PREVENIR LA INFECCION POR VIH MOSTRANDO UNA MAYOR SOLUBILIDAD EN HCl DILUIDO, ASI COMO UNA ABSORCION ORAL Y BIODISPONIBILIDAD MEJORADA
PE1998000432A 1997-05-29 1998-05-28 Inhibidor de proteasa de vih PE75099A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4795097P 1997-05-29 1997-05-29
GBGB9714320.0A GB9714320D0 (en) 1997-07-07 1997-07-07 Hiv protease inhibitor

Publications (1)

Publication Number Publication Date
PE75099A1 true PE75099A1 (es) 1999-08-11

Family

ID=26311845

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000432A PE75099A1 (es) 1997-05-29 1998-05-28 Inhibidor de proteasa de vih

Country Status (22)

Country Link
EP (1) EP0986554A1 (es)
JP (1) JP3267632B2 (es)
KR (1) KR20010013042A (es)
CN (1) CN1257497A (es)
AU (1) AU730245B2 (es)
BG (1) BG103923A (es)
BR (1) BR9809498A (es)
CA (1) CA2291086A1 (es)
EA (1) EA199901095A1 (es)
EE (1) EE9900543A (es)
HR (1) HRP980283A2 (es)
HU (1) HUP0004621A3 (es)
ID (1) ID23858A (es)
IL (1) IL132779A0 (es)
IS (1) IS5240A (es)
NO (1) NO995822L (es)
PE (1) PE75099A1 (es)
PL (1) PL336847A1 (es)
SK (1) SK163299A3 (es)
TR (1) TR199902816T2 (es)
TW (1) TW438799B (es)
WO (1) WO1998054178A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003514910A (ja) * 1999-11-24 2003-04-22 メルク エンド カムパニー インコーポレーテッド Ｈｉｖプロテアーゼ阻害剤としてのガンマ−ヒドロキシ−２−（フルオロアルキルアミノカルボニル）−１−ピペラジンペンタンアミド類
WO2002022582A2 (en) * 2000-09-14 2002-03-21 Ortho-Mcneil Pharmaceutical, Inc. Solid salt forms of n-[2-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]ethyl]-2-oxo-1-piperidineacetamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ278201A (en) * 1993-12-15 1998-01-26 Merck & Co Inc Bicyclic heterocyclically substituted piperazine derivatives as hiv protease inhibitors

Also Published As

Publication number Publication date
WO1998054178A1 (en) 1998-12-03
KR20010013042A (ko) 2001-02-26
BG103923A (en) 2000-06-30
HRP980283A2 (en) 1999-08-31
IL132779A0 (en) 2001-03-19
NO995822D0 (no) 1999-11-26
HUP0004621A2 (hu) 2002-03-28
NO995822L (no) 2000-01-28
SK163299A3 (en) 2000-07-11
AU7595998A (en) 1998-12-30
EE9900543A (et) 2000-06-15
EA199901095A1 (ru) 2000-08-28
PL336847A1 (en) 2000-07-17
CN1257497A (zh) 2000-06-21
TW438799B (en) 2001-06-07
BR9809498A (pt) 2000-06-20
ID23858A (id) 2000-05-25
CA2291086A1 (en) 1998-12-03
TR199902816T2 (xx) 2000-02-21
EP0986554A1 (en) 2000-03-22
JP2000513747A (ja) 2000-10-17
HUP0004621A3 (en) 2002-04-29
IS5240A (is) 1999-11-09
JP3267632B2 (ja) 2002-03-18
AU730245B2 (en) 2001-03-01

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Legal Events

Date Code Title Description
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