NO995822L - Sulfatsalt av en HIV-proteaseinhibitor som har forbedret oral absorpsjon og biotilgjengelighet - Google Patents

Sulfatsalt av en HIV-proteaseinhibitor som har forbedret oral absorpsjon og biotilgjengelighet

Info

Publication number
NO995822L
NO995822L NO995822A NO995822A NO995822L NO 995822 L NO995822 L NO 995822L NO 995822 A NO995822 A NO 995822A NO 995822 A NO995822 A NO 995822A NO 995822 L NO995822 L NO 995822L
Authority
NO
Norway
Prior art keywords
protease inhibitor
sulfate salt
hiv protease
bioavailability
oral absorption
Prior art date
Application number
NO995822A
Other languages
English (en)
Other versions
NO995822D0 (no
Inventor
David Askin
R Scott Hoerrner
Robert M Purick
Paul Reider
Richard J Varsolona
Ralph P Volante
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9714320.0A external-priority patent/GB9714320D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO995822D0 publication Critical patent/NO995822D0/no
Publication of NO995822L publication Critical patent/NO995822L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Sulfatsaltet av en HIV- proteaseinhibitor, Forbindelse A, ¿H2S04 (A) som er anvendelig for behandling av AIDS, ARC eller HIV-infeksjon hos voksne og barn, nærmere bestemt et sul- fatsalt av HIV-proteaseinhibitoren, Forbindelse A, som oppviser forbedret oppløselighet i fortynnet HCl-oppløs- ning (magesyre), hvorved det oppnås meget bedre oral absorpsjon og biotil- gjengelighet i dyremodeller. Det be- skrives også fremgangsmåter for frem- stilling av sulfatsaltet av de angjeld- ende HIV-proteaseinhibitorforbindelser.
NO995822A 1997-05-29 1999-11-26 Sulfatsalt av en HIV-proteaseinhibitor som har forbedret oral absorpsjon og biotilgjengelighet NO995822L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4795097P 1997-05-29 1997-05-29
GBGB9714320.0A GB9714320D0 (en) 1997-07-07 1997-07-07 Hiv protease inhibitor
PCT/US1998/010633 WO1998054178A1 (en) 1997-05-29 1998-05-26 Sulfate salt of an hiv protease inhibitor having an improved oral absorption and bioavailability

Publications (2)

Publication Number Publication Date
NO995822D0 NO995822D0 (no) 1999-11-26
NO995822L true NO995822L (no) 2000-01-28

Family

ID=26311845

Family Applications (1)

Application Number Title Priority Date Filing Date
NO995822A NO995822L (no) 1997-05-29 1999-11-26 Sulfatsalt av en HIV-proteaseinhibitor som har forbedret oral absorpsjon og biotilgjengelighet

Country Status (22)

Country Link
EP (1) EP0986554A1 (no)
JP (1) JP3267632B2 (no)
KR (1) KR20010013042A (no)
CN (1) CN1257497A (no)
AU (1) AU730245B2 (no)
BG (1) BG103923A (no)
BR (1) BR9809498A (no)
CA (1) CA2291086A1 (no)
EA (1) EA199901095A1 (no)
EE (1) EE9900543A (no)
HR (1) HRP980283A2 (no)
HU (1) HUP0004621A3 (no)
ID (1) ID23858A (no)
IL (1) IL132779A0 (no)
IS (1) IS5240A (no)
NO (1) NO995822L (no)
PE (1) PE75099A1 (no)
PL (1) PL336847A1 (no)
SK (1) SK163299A3 (no)
TR (1) TR199902816T2 (no)
TW (1) TW438799B (no)
WO (1) WO1998054178A1 (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2295068T3 (es) 1999-11-24 2008-04-16 MERCK & CO., INC. Gamma-hidroxi-2-(fluoroalquilaminocarbonil)-1-piperazinpentanamidas como inhibidores de la proteasa del vih.
AU2001290743A1 (en) * 2000-09-14 2002-03-26 Ortho-Mcneil Pharmaceutical, Inc. Solid salt forms of n-(2-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)ethyl)-2-oxo-1-piperidineacetamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU692509B2 (en) * 1993-12-15 1998-06-11 Merck & Co., Inc. HIV protease inhibitors

Also Published As

Publication number Publication date
ID23858A (id) 2000-05-25
PL336847A1 (en) 2000-07-17
SK163299A3 (en) 2000-07-11
WO1998054178A1 (en) 1998-12-03
HUP0004621A2 (hu) 2002-03-28
JP3267632B2 (ja) 2002-03-18
IS5240A (is) 1999-11-09
IL132779A0 (en) 2001-03-19
AU7595998A (en) 1998-12-30
PE75099A1 (es) 1999-08-11
NO995822D0 (no) 1999-11-26
EA199901095A1 (ru) 2000-08-28
AU730245B2 (en) 2001-03-01
BR9809498A (pt) 2000-06-20
CN1257497A (zh) 2000-06-21
JP2000513747A (ja) 2000-10-17
BG103923A (en) 2000-06-30
EP0986554A1 (en) 2000-03-22
HUP0004621A3 (en) 2002-04-29
TW438799B (en) 2001-06-07
TR199902816T2 (xx) 2000-02-21
HRP980283A2 (en) 1999-08-31
KR20010013042A (ko) 2001-02-26
CA2291086A1 (en) 1998-12-03
EE9900543A (et) 2000-06-15

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application