PE75099A1 - HIV PROTEASE INHIBITOR - Google Patents
HIV PROTEASE INHIBITORInfo
- Publication number
- PE75099A1 PE75099A1 PE1998000432A PE00043298A PE75099A1 PE 75099 A1 PE75099 A1 PE 75099A1 PE 1998000432 A PE1998000432 A PE 1998000432A PE 00043298 A PE00043298 A PE 00043298A PE 75099 A1 PE75099 A1 PE 75099A1
- Authority
- PE
- Peru
- Prior art keywords
- hiv protease
- crystalline
- refers
- compound
- protease inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I), CRISTALINO O SU MONOETANOLATO, HEMIETANOLATO, SESQUIETANOLATO CRISTALINO; CARACTERIZADO POR SU CURVA DE BARRIDO DIFERENCIAL DE CALORIMETRIA (DSC); PATRON DE DIFRACCION DEL POLVO A LOS RAYOS X. TAMBIEN SE REFIERE AL PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I EN FORMA DE SAL DE SULFATO INHIBE LA PROTEASA DEL VIH POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO O PREVENIR LA INFECCION POR VIH MOSTRANDO UNA MAYOR SOLUBILIDAD EN HCl DILUIDO, ASI COMO UNA ABSORCION ORAL Y BIODISPONIBILIDAD MEJORADAREFERS TO A COMPOUND OF FORMULA (I), CRYSTALLINE OR ITS MONOETHANOLATE, HEMIETHANOLATE, CRYSTALLINE SQUIETHANOLATE; CHARACTERIZED BY ITS DIFFERENTIAL SWEEPING CALORIMETRY CURVE (DSC); DIFFERENCE PATTERN OF DUST TO X-RAYS. ALSO REFERS TO THE PREPARATION PROCEDURE. COMPOUND I IN THE FORM OF SULPHATE SALT INHIBITS HIV PROTEASE SO IT CAN BE USEFUL FOR TREATMENT OR PREVENT HIV INFECTION BY SHOWING MORE SOLUBILITY IN DILUTED HCl, AS WELL AS ORAL ABSORPTION AND BIOAVAILABILITY
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4795097P | 1997-05-29 | 1997-05-29 | |
| GBGB9714320.0A GB9714320D0 (en) | 1997-07-07 | 1997-07-07 | Hiv protease inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE75099A1 true PE75099A1 (en) | 1999-08-11 |
Family
ID=26311845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998000432A PE75099A1 (en) | 1997-05-29 | 1998-05-28 | HIV PROTEASE INHIBITOR |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0986554A1 (en) |
| JP (1) | JP3267632B2 (en) |
| KR (1) | KR20010013042A (en) |
| CN (1) | CN1257497A (en) |
| AU (1) | AU730245B2 (en) |
| BG (1) | BG103923A (en) |
| BR (1) | BR9809498A (en) |
| CA (1) | CA2291086A1 (en) |
| EA (1) | EA199901095A1 (en) |
| EE (1) | EE9900543A (en) |
| HR (1) | HRP980283A2 (en) |
| HU (1) | HUP0004621A3 (en) |
| ID (1) | ID23858A (en) |
| IL (1) | IL132779A0 (en) |
| IS (1) | IS5240A (en) |
| NO (1) | NO995822L (en) |
| PE (1) | PE75099A1 (en) |
| PL (1) | PL336847A1 (en) |
| SK (1) | SK163299A3 (en) |
| TR (1) | TR199902816T2 (en) |
| TW (1) | TW438799B (en) |
| WO (1) | WO1998054178A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003514910A (en) | 1999-11-24 | 2003-04-22 | メルク エンド カムパニー インコーポレーテッド | Gamma-hydroxy-2- (fluoroalkylaminocarbonyl) -1-piperazinepentanamides as HIV protease inhibitors |
| US20020082421A1 (en) * | 2000-09-14 | 2002-06-27 | Abdel-Magid Ahmed F. | Novel solid salt forms of N-[2-[4-[2-(1- methylethoxy)phenyl]-1-piperazinyl]-2-oxo-1piperidineacetamide |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0734387B1 (en) * | 1993-12-15 | 2002-04-10 | Merck & Co. Inc. | Hiv protease inhibitors |
-
1998
- 1998-05-20 TW TW087107834A patent/TW438799B/en active
- 1998-05-26 EP EP98923741A patent/EP0986554A1/en not_active Withdrawn
- 1998-05-26 SK SK1632-99A patent/SK163299A3/en unknown
- 1998-05-26 ID IDW991462A patent/ID23858A/en unknown
- 1998-05-26 IL IL13277998A patent/IL132779A0/en unknown
- 1998-05-26 JP JP50079999A patent/JP3267632B2/en not_active Expired - Fee Related
- 1998-05-26 BR BR9809498-0A patent/BR9809498A/en not_active Application Discontinuation
- 1998-05-26 PL PL98336847A patent/PL336847A1/en unknown
- 1998-05-26 TR TR1999/02816T patent/TR199902816T2/en unknown
- 1998-05-26 CN CN98805372A patent/CN1257497A/en active Pending
- 1998-05-26 AU AU75959/98A patent/AU730245B2/en not_active Ceased
- 1998-05-26 EE EEP199900543A patent/EE9900543A/en unknown
- 1998-05-26 CA CA002291086A patent/CA2291086A1/en not_active Abandoned
- 1998-05-26 WO PCT/US1998/010633 patent/WO1998054178A1/en not_active Application Discontinuation
- 1998-05-26 HU HU0004621A patent/HUP0004621A3/en unknown
- 1998-05-26 EA EA199901095A patent/EA199901095A1/en unknown
- 1998-05-26 KR KR1019997011018A patent/KR20010013042A/en not_active Application Discontinuation
- 1998-05-28 HR HR9714320.0A patent/HRP980283A2/en not_active Application Discontinuation
- 1998-05-28 PE PE1998000432A patent/PE75099A1/en not_active Application Discontinuation
-
1999
- 1999-11-09 IS IS5240A patent/IS5240A/en unknown
- 1999-11-24 BG BG103923A patent/BG103923A/en unknown
- 1999-11-26 NO NO995822A patent/NO995822L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0986554A1 (en) | 2000-03-22 |
| KR20010013042A (en) | 2001-02-26 |
| HRP980283A2 (en) | 1999-08-31 |
| BG103923A (en) | 2000-06-30 |
| IS5240A (en) | 1999-11-09 |
| HUP0004621A3 (en) | 2002-04-29 |
| EA199901095A1 (en) | 2000-08-28 |
| EE9900543A (en) | 2000-06-15 |
| AU7595998A (en) | 1998-12-30 |
| WO1998054178A1 (en) | 1998-12-03 |
| CN1257497A (en) | 2000-06-21 |
| IL132779A0 (en) | 2001-03-19 |
| JP3267632B2 (en) | 2002-03-18 |
| NO995822L (en) | 2000-01-28 |
| TR199902816T2 (en) | 2000-02-21 |
| JP2000513747A (en) | 2000-10-17 |
| TW438799B (en) | 2001-06-07 |
| CA2291086A1 (en) | 1998-12-03 |
| ID23858A (en) | 2000-05-25 |
| SK163299A3 (en) | 2000-07-11 |
| PL336847A1 (en) | 2000-07-17 |
| BR9809498A (en) | 2000-06-20 |
| NO995822D0 (en) | 1999-11-26 |
| HUP0004621A2 (en) | 2002-03-28 |
| AU730245B2 (en) | 2001-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0307267A (en) | Heterocyclic compounds, active as inhibitors of beta-lactams | |
| CY1106801T1 (en) | NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE AS DRUGS, PARTICULARLY AS ANTI-BACTERIALS | |
| BR0111263A (en) | 2-Aminocarbonyl-9h-purine derivatives | |
| MX9403380A (en) | HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS. | |
| PE20110388A1 (en) | CRYSTALLINE FORMS OF A PEPTIDE DERIVATIVE AS HCV INHIBITORS | |
| CY1108559T1 (en) | SALTS of Valsartan | |
| CO5261589A1 (en) | HETEROCICLIC COMPOUNDS, ITS PRODUCTION AND ITS USE | |
| BR0212477A (en) | 7-aza [2.2.1] Substituted bicycloheptanes for the treatment of disease | |
| TR200200579T2 (en) | Amino-thyrazolpyridine derivatives. | |
| ECSP045221A (en) | SALTS OF VALSARTAN | |
| DE60142891D1 (en) | AZETIDINE DERIVATIVES PHARMACEUTICAL COMPOSITIONS, THE AZETIDINE DERIVATIVES AND THEIR PREPARATION | |
| BR0109836A (en) | Synthesis process of perindopril and its pharmaceutically acceptable salts | |
| ES2191977T3 (en) | SOLUTIONS AND DISPERSIONS IN SOLID STATE OF PHARMACOS LITTLE SOLUBLES IN WATER. | |
| ES2061309T3 (en) | CATALYST TO PREPARE ETHYLENE OXIDE AND PROCEDURE FOR ITS PREPARATION AND USE. | |
| ECSP044992A (en) | INHIBITORS OF THE ALQUÍN-ARIL FOSFODIESTERASA-4 | |
| AR034985A1 (en) | BICYCLE COMPOUND; PRODUCTION AND USE OF THE SAME | |
| BR9908470A (en) | Compound, pharmaceutical composition, and process to treat conditions mediated by avb3 inegrin in a mammal in need of such treatment | |
| UY26780A1 (en) | CYCLALQUIL AVB3 ANTAGONISTS | |
| NO20052907D0 (en) | Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferative agents. | |
| AR031940A1 (en) | HERBICIDE AGENT | |
| BR0101230A (en) | Process for the preparation of 11-amino-3-chloro-6,11-dihydro-5-5-dioxo-6-methyl-dibenzo [c, f] [1,2] thiazepine and application for the synthesis of detianeptine | |
| UY27980A1 (en) | INDOLES 2,7-REPLACED | |
| UY27577A1 (en) | HIV INTEGRAS INHIBITORS | |
| BR0309028A (en) | Polycyclic compounds as potent alpha2-adrenoceptor antagonists | |
| CO5570696A2 (en) | 1-AMINO-ALQUILCICLOHEXANOS INSATURATED AS ANTAGONISTS OF NMDA, 5HT3 AND NEURONAL NICOTINIC RECEPTORS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |