PE75099A1 - HIV PROTEASE INHIBITOR - Google Patents
HIV PROTEASE INHIBITORInfo
- Publication number
- PE75099A1 PE75099A1 PE1998000432A PE00043298A PE75099A1 PE 75099 A1 PE75099 A1 PE 75099A1 PE 1998000432 A PE1998000432 A PE 1998000432A PE 00043298 A PE00043298 A PE 00043298A PE 75099 A1 PE75099 A1 PE 75099A1
- Authority
- PE
- Peru
- Prior art keywords
- hiv protease
- crystalline
- refers
- compound
- protease inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I), CRISTALINO O SU MONOETANOLATO, HEMIETANOLATO, SESQUIETANOLATO CRISTALINO; CARACTERIZADO POR SU CURVA DE BARRIDO DIFERENCIAL DE CALORIMETRIA (DSC); PATRON DE DIFRACCION DEL POLVO A LOS RAYOS X. TAMBIEN SE REFIERE AL PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I EN FORMA DE SAL DE SULFATO INHIBE LA PROTEASA DEL VIH POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO O PREVENIR LA INFECCION POR VIH MOSTRANDO UNA MAYOR SOLUBILIDAD EN HCl DILUIDO, ASI COMO UNA ABSORCION ORAL Y BIODISPONIBILIDAD MEJORADAREFERS TO A COMPOUND OF FORMULA (I), CRYSTALLINE OR ITS MONOETHANOLATE, HEMIETHANOLATE, CRYSTALLINE SQUIETHANOLATE; CHARACTERIZED BY ITS DIFFERENTIAL SWEEPING CALORIMETRY CURVE (DSC); DIFFERENCE PATTERN OF DUST TO X-RAYS. ALSO REFERS TO THE PREPARATION PROCEDURE. COMPOUND I IN THE FORM OF SULPHATE SALT INHIBITS HIV PROTEASE SO IT CAN BE USEFUL FOR TREATMENT OR PREVENT HIV INFECTION BY SHOWING MORE SOLUBILITY IN DILUTED HCl, AS WELL AS ORAL ABSORPTION AND BIOAVAILABILITY
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4795097P | 1997-05-29 | 1997-05-29 | |
| GBGB9714320.0A GB9714320D0 (en) | 1997-07-07 | 1997-07-07 | Hiv protease inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE75099A1 true PE75099A1 (en) | 1999-08-11 |
Family
ID=26311845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998000432A PE75099A1 (en) | 1997-05-29 | 1998-05-28 | HIV PROTEASE INHIBITOR |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0986554A1 (en) |
| JP (1) | JP3267632B2 (en) |
| KR (1) | KR20010013042A (en) |
| CN (1) | CN1257497A (en) |
| AU (1) | AU730245B2 (en) |
| BG (1) | BG103923A (en) |
| BR (1) | BR9809498A (en) |
| CA (1) | CA2291086A1 (en) |
| EA (1) | EA199901095A1 (en) |
| EE (1) | EE9900543A (en) |
| HR (1) | HRP980283A2 (en) |
| HU (1) | HUP0004621A3 (en) |
| ID (1) | ID23858A (en) |
| IL (1) | IL132779A0 (en) |
| IS (1) | IS5240A (en) |
| NO (1) | NO995822L (en) |
| PE (1) | PE75099A1 (en) |
| PL (1) | PL336847A1 (en) |
| SK (1) | SK163299A3 (en) |
| TR (1) | TR199902816T2 (en) |
| TW (1) | TW438799B (en) |
| WO (1) | WO1998054178A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003514910A (en) * | 1999-11-24 | 2003-04-22 | メルク エンド カムパニー インコーポレーテッド | Gamma-hydroxy-2- (fluoroalkylaminocarbonyl) -1-piperazinepentanamides as HIV protease inhibitors |
| WO2002022582A2 (en) * | 2000-09-14 | 2002-03-21 | Ortho-Mcneil Pharmaceutical, Inc. | Solid salt forms of n-[2-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]ethyl]-2-oxo-1-piperidineacetamide |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ278201A (en) * | 1993-12-15 | 1998-01-26 | Merck & Co Inc | Bicyclic heterocyclically substituted piperazine derivatives as hiv protease inhibitors |
-
1998
- 1998-05-20 TW TW087107834A patent/TW438799B/en active
- 1998-05-26 TR TR1999/02816T patent/TR199902816T2/en unknown
- 1998-05-26 ID IDW991462A patent/ID23858A/en unknown
- 1998-05-26 PL PL98336847A patent/PL336847A1/en unknown
- 1998-05-26 EE EEP199900543A patent/EE9900543A/en unknown
- 1998-05-26 EP EP98923741A patent/EP0986554A1/en not_active Withdrawn
- 1998-05-26 IL IL13277998A patent/IL132779A0/en unknown
- 1998-05-26 BR BR9809498-0A patent/BR9809498A/en not_active Application Discontinuation
- 1998-05-26 KR KR1019997011018A patent/KR20010013042A/en not_active Application Discontinuation
- 1998-05-26 JP JP50079999A patent/JP3267632B2/en not_active Expired - Fee Related
- 1998-05-26 WO PCT/US1998/010633 patent/WO1998054178A1/en not_active Application Discontinuation
- 1998-05-26 CN CN98805372A patent/CN1257497A/en active Pending
- 1998-05-26 HU HU0004621A patent/HUP0004621A3/en unknown
- 1998-05-26 CA CA002291086A patent/CA2291086A1/en not_active Abandoned
- 1998-05-26 SK SK1632-99A patent/SK163299A3/en unknown
- 1998-05-26 EA EA199901095A patent/EA199901095A1/en unknown
- 1998-05-26 AU AU75959/98A patent/AU730245B2/en not_active Ceased
- 1998-05-28 PE PE1998000432A patent/PE75099A1/en not_active Application Discontinuation
- 1998-05-28 HR HR9714320.0A patent/HRP980283A2/en not_active Application Discontinuation
-
1999
- 1999-11-09 IS IS5240A patent/IS5240A/en unknown
- 1999-11-24 BG BG103923A patent/BG103923A/en unknown
- 1999-11-26 NO NO995822A patent/NO995822L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998054178A1 (en) | 1998-12-03 |
| KR20010013042A (en) | 2001-02-26 |
| BG103923A (en) | 2000-06-30 |
| HRP980283A2 (en) | 1999-08-31 |
| IL132779A0 (en) | 2001-03-19 |
| NO995822D0 (en) | 1999-11-26 |
| HUP0004621A2 (en) | 2002-03-28 |
| NO995822L (en) | 2000-01-28 |
| SK163299A3 (en) | 2000-07-11 |
| AU7595998A (en) | 1998-12-30 |
| EE9900543A (en) | 2000-06-15 |
| EA199901095A1 (en) | 2000-08-28 |
| PL336847A1 (en) | 2000-07-17 |
| CN1257497A (en) | 2000-06-21 |
| TW438799B (en) | 2001-06-07 |
| BR9809498A (en) | 2000-06-20 |
| ID23858A (en) | 2000-05-25 |
| CA2291086A1 (en) | 1998-12-03 |
| TR199902816T2 (en) | 2000-02-21 |
| EP0986554A1 (en) | 2000-03-22 |
| JP2000513747A (en) | 2000-10-17 |
| HUP0004621A3 (en) | 2002-04-29 |
| IS5240A (en) | 1999-11-09 |
| JP3267632B2 (en) | 2002-03-18 |
| AU730245B2 (en) | 2001-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |