BR9809498A - Compound, process for its production, pharmaceutical composition, process for its production, and processes for treating HIV infection, for treating AIDS, for inhibiting a hiv protease, and for producing an ethanolate solvate. - Google Patents
Compound, process for its production, pharmaceutical composition, process for its production, and processes for treating HIV infection, for treating AIDS, for inhibiting a hiv protease, and for producing an ethanolate solvate.Info
- Publication number
- BR9809498A BR9809498A BR9809498-0A BR9809498A BR9809498A BR 9809498 A BR9809498 A BR 9809498A BR 9809498 A BR9809498 A BR 9809498A BR 9809498 A BR9809498 A BR 9809498A
- Authority
- BR
- Brazil
- Prior art keywords
- production
- treating
- compound
- processes
- hiv protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSTO CRISTALINO, PROCESSO PARA SUA PRODUçãO, COMPOSIçãO FARMACêUTICA, PROCESSO PARA SUA PRODUçãO, E, PROCESSOS PARA TRATAMENTO DE INFECçãO PELO HIV, PARA TRATAMENTO DA AIDS E PARA INIBIçãO DE UMA HIV PROTEASE". Esta invenção diz respeito a um sal de sulfato de um inibidor da HIV protease, Composto (A) que é útil no tratamento da infecção de AIDS, ARC ou HIV em adultos e crianças. Mais especificamente, a invenção fornece um sal de sulfato do inibidor da HIV protease, Composto (A), tendo solubilidade substancialmente melhorada em solução diluída de HC1 (ácido gástrico), que resulta em absorção oral e biodisponibilidade muito maiores em modelos de animais. Processos para produzir o sal de sulfato dos compostos específicos inibidores de HIV protease, também são apresentados."CRYSTALLINE COMPOUND, PROCESS FOR ITS PRODUCTION, PHARMACEUTICAL COMPOSITION, PROCESS FOR ITS PRODUCTION, AND, PROCESSES FOR TREATING HIV INFECTION, FOR TREATING AIDS AND FOR INHIBITING HIV PROTEASE". This invention relates to a sulfate salt of an HIV protease inhibitor, Compound (A) which is useful in the treatment of AIDS, ARC or HIV infection in adults and children. More specifically, the invention provides a sulfate salt of the HIV protease inhibitor, Compound (A), having substantially improved solubility in diluted HCl (gastric acid) solution, which results in much greater oral absorption and bioavailability in animal models. Processes for producing the sulfate salt of specific HIV protease inhibitor compounds are also presented.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4795097P | 1997-05-29 | 1997-05-29 | |
| GBGB9714320.0A GB9714320D0 (en) | 1997-07-07 | 1997-07-07 | Hiv protease inhibitor |
| PCT/US1998/010633 WO1998054178A1 (en) | 1997-05-29 | 1998-05-26 | Sulfate salt of an hiv protease inhibitor having an improved oral absorption and bioavailability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9809498A true BR9809498A (en) | 2000-06-20 |
Family
ID=26311845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9809498-0A BR9809498A (en) | 1997-05-29 | 1998-05-26 | Compound, process for its production, pharmaceutical composition, process for its production, and processes for treating HIV infection, for treating AIDS, for inhibiting a hiv protease, and for producing an ethanolate solvate. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0986554A1 (en) |
| JP (1) | JP3267632B2 (en) |
| KR (1) | KR20010013042A (en) |
| CN (1) | CN1257497A (en) |
| AU (1) | AU730245B2 (en) |
| BG (1) | BG103923A (en) |
| BR (1) | BR9809498A (en) |
| CA (1) | CA2291086A1 (en) |
| EA (1) | EA199901095A1 (en) |
| EE (1) | EE9900543A (en) |
| HR (1) | HRP980283A2 (en) |
| HU (1) | HUP0004621A3 (en) |
| ID (1) | ID23858A (en) |
| IL (1) | IL132779A0 (en) |
| IS (1) | IS5240A (en) |
| NO (1) | NO995822L (en) |
| PE (1) | PE75099A1 (en) |
| PL (1) | PL336847A1 (en) |
| SK (1) | SK163299A3 (en) |
| TR (1) | TR199902816T2 (en) |
| TW (1) | TW438799B (en) |
| WO (1) | WO1998054178A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003514910A (en) | 1999-11-24 | 2003-04-22 | メルク エンド カムパニー インコーポレーテッド | Gamma-hydroxy-2- (fluoroalkylaminocarbonyl) -1-piperazinepentanamides as HIV protease inhibitors |
| US20020082421A1 (en) * | 2000-09-14 | 2002-06-27 | Abdel-Magid Ahmed F. | Novel solid salt forms of N-[2-[4-[2-(1- methylethoxy)phenyl]-1-piperazinyl]-2-oxo-1piperidineacetamide |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0734387B1 (en) * | 1993-12-15 | 2002-04-10 | Merck & Co. Inc. | Hiv protease inhibitors |
-
1998
- 1998-05-20 TW TW087107834A patent/TW438799B/en active
- 1998-05-26 EP EP98923741A patent/EP0986554A1/en not_active Withdrawn
- 1998-05-26 SK SK1632-99A patent/SK163299A3/en unknown
- 1998-05-26 ID IDW991462A patent/ID23858A/en unknown
- 1998-05-26 IL IL13277998A patent/IL132779A0/en unknown
- 1998-05-26 JP JP50079999A patent/JP3267632B2/en not_active Expired - Fee Related
- 1998-05-26 BR BR9809498-0A patent/BR9809498A/en not_active Application Discontinuation
- 1998-05-26 PL PL98336847A patent/PL336847A1/en unknown
- 1998-05-26 TR TR1999/02816T patent/TR199902816T2/en unknown
- 1998-05-26 CN CN98805372A patent/CN1257497A/en active Pending
- 1998-05-26 AU AU75959/98A patent/AU730245B2/en not_active Ceased
- 1998-05-26 EE EEP199900543A patent/EE9900543A/en unknown
- 1998-05-26 CA CA002291086A patent/CA2291086A1/en not_active Abandoned
- 1998-05-26 WO PCT/US1998/010633 patent/WO1998054178A1/en not_active Application Discontinuation
- 1998-05-26 HU HU0004621A patent/HUP0004621A3/en unknown
- 1998-05-26 EA EA199901095A patent/EA199901095A1/en unknown
- 1998-05-26 KR KR1019997011018A patent/KR20010013042A/en not_active Application Discontinuation
- 1998-05-28 HR HR9714320.0A patent/HRP980283A2/en not_active Application Discontinuation
- 1998-05-28 PE PE1998000432A patent/PE75099A1/en not_active Application Discontinuation
-
1999
- 1999-11-09 IS IS5240A patent/IS5240A/en unknown
- 1999-11-24 BG BG103923A patent/BG103923A/en unknown
- 1999-11-26 NO NO995822A patent/NO995822L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0986554A1 (en) | 2000-03-22 |
| KR20010013042A (en) | 2001-02-26 |
| HRP980283A2 (en) | 1999-08-31 |
| BG103923A (en) | 2000-06-30 |
| IS5240A (en) | 1999-11-09 |
| HUP0004621A3 (en) | 2002-04-29 |
| EA199901095A1 (en) | 2000-08-28 |
| EE9900543A (en) | 2000-06-15 |
| AU7595998A (en) | 1998-12-30 |
| WO1998054178A1 (en) | 1998-12-03 |
| CN1257497A (en) | 2000-06-21 |
| IL132779A0 (en) | 2001-03-19 |
| JP3267632B2 (en) | 2002-03-18 |
| NO995822L (en) | 2000-01-28 |
| TR199902816T2 (en) | 2000-02-21 |
| JP2000513747A (en) | 2000-10-17 |
| TW438799B (en) | 2001-06-07 |
| CA2291086A1 (en) | 1998-12-03 |
| ID23858A (en) | 2000-05-25 |
| SK163299A3 (en) | 2000-07-11 |
| PL336847A1 (en) | 2000-07-17 |
| PE75099A1 (en) | 1999-08-11 |
| NO995822D0 (en) | 1999-11-26 |
| HUP0004621A2 (en) | 2002-03-28 |
| AU730245B2 (en) | 2001-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |