TR199901273T2 - Farnezil protein transferaz inhibisyonu için yararli bilesikler. - Google Patents

Farnezil protein transferaz inhibisyonu için yararli bilesikler.

Info

Publication number
TR199901273T2
TR199901273T2 TR1999/01273T TR9901273T TR199901273T2 TR 199901273 T2 TR199901273 T2 TR 199901273T2 TR 1999/01273 T TR1999/01273 T TR 1999/01273T TR 9901273 T TR9901273 T TR 9901273T TR 199901273 T2 TR199901273 T2 TR 199901273T2
Authority
TR
Turkey
Prior art keywords
formula
protein transferase
inhibition
farnesyl protein
compounds useful
Prior art date
Application number
TR1999/01273T
Other languages
English (en)
Inventor
Njoroge F.George
G. Taveras Arthur
J. Doll Ronald
Lalwani Tarik
Alvarez Carmen
W. Remiszewski Stacy
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of TR199901273T2 publication Critical patent/TR199901273T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

(Formül(1.0)), (Formül(1.4)), (Formül(1.5)); Yeni formül (1.0) bilesikleri açiklanmaktadir. Formül (1.0) bilesikleri formül (1.4) veya (1.5) bilesikleriyle ifade edilmektedir; burada R1,R3 ve R4'ün her biri bagimsiz olarak halodan seçilir. Ayrica farnezil protein transferazi ve tümör hücreleri gibi anormal hücrelerin büyümesini inhibe etme yöntemleri açiklanmaktadir.
TR1999/01273T 1996-09-13 1997-09-11 Farnezil protein transferaz inhibisyonu için yararli bilesikler. TR199901273T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71022596A 1996-09-13 1996-09-13
US87745397A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
TR199901273T2 true TR199901273T2 (tr) 1999-09-21

Family

ID=27108399

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/01273T TR199901273T2 (tr) 1996-09-13 1997-09-11 Farnezil protein transferaz inhibisyonu için yararli bilesikler.

Country Status (20)

Country Link
EP (1) EP0942906B1 (tr)
JP (1) JP2002515052A (tr)
KR (1) KR20000068550A (tr)
CN (1) CN1248253A (tr)
AT (1) ATE281450T1 (tr)
AU (1) AU7243298A (tr)
BR (1) BR9712035A (tr)
CA (1) CA2264511C (tr)
CZ (1) CZ84299A3 (tr)
DE (1) DE69731481T2 (tr)
ES (1) ES2232888T3 (tr)
HU (1) HUP0000240A2 (tr)
ID (1) ID22067A (tr)
IL (1) IL128930A0 (tr)
NO (1) NO991231L (tr)
NZ (1) NZ334342A (tr)
PL (1) PL332279A1 (tr)
SK (1) SK33299A3 (tr)
TR (1) TR199901273T2 (tr)
WO (1) WO1998030558A2 (tr)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
KR920014799A (ko) * 1991-01-18 1992-08-25 나오가따 다이도 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제
ZA947969B (en) * 1993-10-15 1996-07-12 Schering Corp Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
ATE210652T1 (de) * 1993-10-15 2001-12-15 Schering Corp Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
JP3193725B2 (ja) * 1995-12-22 2001-07-30 シェーリング コーポレイション Ｇ―タンパク質機能の阻害および増殖性疾患の処置に有用な三環式アミド

Also Published As

Publication number Publication date
CA2264511A1 (en) 1998-07-16
NO991231L (no) 1999-05-14
DE69731481T2 (de) 2005-10-27
NZ334342A (en) 2000-07-28
DE69731481D1 (de) 2004-12-09
IL128930A0 (en) 2000-02-17
HUP0000240A2 (hu) 2001-04-28
ATE281450T1 (de) 2004-11-15
AU7243298A (en) 1998-08-03
ID22067A (id) 1999-08-26
ES2232888T3 (es) 2005-06-01
EP0942906B1 (en) 2004-11-03
WO1998030558A3 (en) 1998-10-08
NO991231D0 (no) 1999-03-12
CZ84299A3 (cs) 1999-09-15
CA2264511C (en) 2003-08-05
CN1248253A (zh) 2000-03-22
WO1998030558A2 (en) 1998-07-16
SK33299A3 (en) 2000-06-12
BR9712035A (pt) 1999-08-24
JP2002515052A (ja) 2002-05-21
PL332279A1 (en) 1999-08-30
KR20000068550A (ko) 2000-11-25
EP0942906A2 (en) 1999-09-22

Similar Documents

Publication Publication Date Title
TR199901276T2 (tr) Farnezil protein transferaz inhibisyonu için yararli bilesikler.
TR199901275T2 (tr) Farnezil protein transferaz inhibisyonu için yararli bilesikler.
TR199901205T2 (tr) Farnesil protein transferaz inhibasyonu için kullanilan degistirilmis benzosikloheptapiridin türevleri
TR199901273T2 (tr) Farnezil protein transferaz inhibisyonu için yararli bilesikler.
TR200003580T2 (tr) Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri
ATE247106T1 (de) Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren