TR199901143T2 - N-(Imidazolilbütil ) benzensülfonamid türevleri, hazirlanmalari ve terapide uygulanmalari. - Google Patents

N-(Imidazolilbütil ) benzensülfonamid türevleri, hazirlanmalari ve terapide uygulanmalari.

Info

Publication number
TR199901143T2
TR199901143T2 TR1999/01143T TR9901143T TR199901143T2 TR 199901143 T2 TR199901143 T2 TR 199901143T2 TR 1999/01143 T TR1999/01143 T TR 1999/01143T TR 9901143 T TR9901143 T TR 9901143T TR 199901143 T2 TR199901143 T2 TR 199901143T2
Authority
TR
Turkey
Prior art keywords
alkyl
group
imidazolylbutyl
therapy
preparation
Prior art date
Application number
TR1999/01143T
Other languages
English (en)
Inventor
Altenburger Jean-Michel
Lassalle Gilbert
Martin Valerie
Galtier Daniel
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of TR199901143T2 publication Critical patent/TR199901143T2/tr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68Halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Formül (I)'deki bilesikler olup R1 ve R'1 hidrojen, halojen (C1-C4) alkil grubunu simgelemekte. R2; bir piperidin-1-il, istege bagli olarak substitüsyonu gerçeklestirilen 1,2,3,6-tetra-hidropiridin-1-il, hekzahidro-1H-azepin-1-il, heptahidroazosin-1il, oktahidro-1H-hidropiridin-1-il, FORMÜL: (A-B=-CONR",m=1 ila 2 ve p=1 ila 2) veya grubunu (Q= karbon veya nitrojen, D=(C1-C4) alkil veya -CH2CF3 ve r=1 ila 3) simgelemekte; R3;(C1-C5)alkil, -COR5[R5;(C1-C4)alkil, -(CH2)nOCH3, -CH2O(C2H4O)nCH3, -(CH2)nCF3 veya -(CH2)nOH(n=1 ila 4)grubudur], SO2R6, -CONHR6 veya SO2N(R6)2 grubunu (R6, (C1-C4) alkil grubudur) simgelemekte, R4 hidrojen veya halojeni simgelemekte ve A ise fenil veya istege bagli olarak substitüsyonu gerçeklestirilen heterosaykil veya sayklo (C5-C8) alkil simgelemektedir.
TR1999/01143T 1996-11-22 1997-11-19 N-(Imidazolilbütil ) benzensülfonamid türevleri, hazirlanmalari ve terapide uygulanmalari. TR199901143T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9614309A FR2756285B1 (fr) 1996-11-22 1996-11-22 Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
TR199901143T2 true TR199901143T2 (tr) 1999-08-23

Family

ID=9497920

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/01143T TR199901143T2 (tr) 1996-11-22 1997-11-19 N-(Imidazolilbütil ) benzensülfonamid türevleri, hazirlanmalari ve terapide uygulanmalari.

Country Status (20)

Country Link
EP (1) EP0946517A1 (tr)
JP (1) JP2001504128A (tr)
KR (1) KR20000069063A (tr)
CN (1) CN1238765A (tr)
AR (1) AR009627A1 (tr)
AU (1) AU5226498A (tr)
BG (1) BG103414A (tr)
BR (1) BR9713291A (tr)
CA (1) CA2270478A1 (tr)
CO (1) CO4910158A1 (tr)
CZ (1) CZ178299A3 (tr)
EE (1) EE9900201A (tr)
FR (1) FR2756285B1 (tr)
HU (1) HUP9904599A2 (tr)
IL (1) IL129546A0 (tr)
NO (1) NO992436L (tr)
SK (1) SK66799A3 (tr)
TR (1) TR199901143T2 (tr)
WO (1) WO1998022443A1 (tr)
ZA (1) ZA9710515B (tr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2783521B1 (fr) * 1998-09-18 2002-04-26 Synthelabo Derives de n-(arginyl) benzenesulfonamide, leur preparation et leur application en therapeutique
FR2806722B1 (fr) * 2000-03-23 2002-05-17 Sanofi Synthelabo Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique
AU2014407862B2 (en) 2014-09-29 2020-03-26 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689130B1 (fr) * 1992-03-30 1994-05-27 Synthelabo Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.
FR2710066B1 (fr) * 1993-09-14 1995-10-20 Synthelabo Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2727410B1 (fr) * 1994-11-25 1996-12-20 Synthelabo Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese
FR2728570B1 (fr) * 1994-12-23 1997-04-11 Synthelabo Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique
DE19548797A1 (de) * 1995-12-27 1997-07-03 Thomae Gmbh Dr K Substituierte 2-Amino-imidazole, ihre Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
CA2270478A1 (en) 1998-05-28
NO992436D0 (no) 1999-05-20
FR2756285B1 (fr) 1998-12-18
KR20000069063A (ko) 2000-11-25
AU5226498A (en) 1998-06-10
JP2001504128A (ja) 2001-03-27
EE9900201A (et) 1999-12-15
FR2756285A1 (fr) 1998-05-29
CZ178299A3 (cs) 1999-08-11
IL129546A0 (en) 2000-02-29
NO992436L (no) 1999-07-22
EP0946517A1 (fr) 1999-10-06
BG103414A (en) 2000-01-31
HUP9904599A2 (hu) 2000-06-28
SK66799A3 (en) 2000-02-14
CO4910158A1 (es) 2000-04-24
BR9713291A (pt) 1999-10-26
ZA9710515B (en) 1998-06-10
WO1998022443A1 (fr) 1998-05-28
AR009627A1 (es) 2000-04-26
CN1238765A (zh) 1999-12-15

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