TR199901132T2 - N-(aril/heteoaril) amino asit türevleri, bunlari içeren farmasötik bilesimler ve böyle bilesikler kullanilarak -amiloid peptidinin salinmasini ve/veya sentezini inhibe etmek için yöntemler. - Google Patents

N-(aril/heteoaril) amino asit türevleri, bunlari içeren farmasötik bilesimler ve böyle bilesikler kullanilarak -amiloid peptidinin salinmasini ve/veya sentezini inhibe etmek için yöntemler.

Info

Publication number
TR199901132T2
TR199901132T2 TR1999/01132T TR9901132T TR199901132T2 TR 199901132 T2 TR199901132 T2 TR 199901132T2 TR 1999/01132 T TR1999/01132 T TR 1999/01132T TR 9901132 T TR9901132 T TR 9901132T TR 199901132 T2 TR199901132 T2 TR 199901132T2
Authority
TR
Turkey
Prior art keywords
synthesis
release
inhibit
compounds
methods
Prior art date
Application number
TR1999/01132T
Other languages
English (en)
Inventor
E. Audia James
K. Folmer Beverly
John Verghese
H. Latimer Lee
S. Nissen Jeffrey
J. Porter Warren
D. Thorsett Eugene
Wu Jing
Original Assignee
Elan Pharmaceuticals, Inc.
Eli Lilly & Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharmaceuticals, Inc., Eli Lilly & Company filed Critical Elan Pharmaceuticals, Inc.
Publication of TR199901132T2 publication Critical patent/TR199901132T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

- Amiloid peptidinin salinmasini ve/veya sentezini inhibe eden ve dolayisiyla Alzheimer hastaliginin tedavisinde kullanilabilen bilesikler açiklanmaktadir. Ayrica -Amiloid peptidinin salinmasini ve/veya sentezini inhibe eden bir bilesik içeren farmasötik bilesimler ve Alzheimer hastaliginin böyle bilesimlerle profilaktik ve terapötik tedavisi için yöntemler açiklanmaktadir.
TR1999/01132T 1996-11-22 1997-11-20 N-(aril/heteoaril) amino asit türevleri, bunlari içeren farmasötik bilesimler ve böyle bilesikler kullanilarak -amiloid peptidinin salinmasini ve/veya sentezini inhibe etmek için yöntemler. TR199901132T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75533496A 1996-11-22 1996-11-22

Publications (1)

Publication Number Publication Date
TR199901132T2 true TR199901132T2 (tr) 1999-08-23

Family

ID=25038718

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/01132T TR199901132T2 (tr) 1996-11-22 1997-11-20 N-(aril/heteoaril) amino asit türevleri, bunlari içeren farmasötik bilesimler ve böyle bilesikler kullanilarak -amiloid peptidinin salinmasini ve/veya sentezini inhibe etmek için yöntemler.

Country Status (13)

Country Link
EP (1) EP0942923A2 (tr)
JP (1) JP2001519769A (tr)
CN (1) CN1237978A (tr)
AU (1) AU5354398A (tr)
BR (1) BR9714358A (tr)
CA (1) CA2270876A1 (tr)
HU (1) HUP0001383A3 (tr)
ID (1) ID22275A (tr)
IL (1) IL129477A0 (tr)
NO (1) NO992426L (tr)
NZ (1) NZ335157A (tr)
TR (1) TR199901132T2 (tr)
WO (1) WO1998022493A2 (tr)

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NZ509241A (en) 1998-08-07 2003-08-29 Du Pont Pharm Co Succinoylamino lactams as inhibitors of alpha-beta protein production
EP1131634A2 (en) 1998-09-30 2001-09-12 Elan Pharmaceuticals, Inc. Determining the mechanism of beta-amyloid peptide generation
US6737038B1 (en) 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
IL142816A0 (en) 1998-12-24 2002-03-10 Du Pont Pharm Co SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
EP1218377A1 (en) 1999-10-08 2002-07-03 Bristol-Myers Squibb Pharma Company AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION
EP1261610A2 (en) 2000-02-17 2002-12-04 Bristol-Myers Squibb Pharma Company Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production
US6713476B2 (en) 2000-04-03 2004-03-30 Dupont Pharmaceuticals Company Substituted cycloalkyls as inhibitors of a beta protein production
WO2001074783A1 (en) 2000-04-03 2001-10-11 Dupont Pharmaceuticals Company Cyclic lactams as inhibitors of a βετα protein production
US6632812B2 (en) 2000-04-11 2003-10-14 Dupont Pharmaceuticals Company Substituted lactams as inhibitors of Aβ protein production
US6878363B2 (en) 2000-05-17 2005-04-12 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
AU783857B2 (en) 2000-06-01 2005-12-15 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a beta protein production
US6432944B1 (en) 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
PT1334091E (pt) 2000-08-24 2013-01-07 Univ Pittsburgh Derivados de tioflavina e seu uso no diagnóstico e terapia da doença de alzheimer
EP1341779B1 (en) 2000-12-13 2006-06-21 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production
US6657070B2 (en) 2000-12-13 2003-12-02 Wyeth Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
CH698246B1 (de) * 2001-12-20 2009-06-30 Hoffmann La Roche Test zur Identifizierung von Inhibitoren von Beta-Sekretasen.
DE10306202A1 (de) * 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
AU2004221897B2 (en) * 2003-03-14 2010-11-18 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Benzothiazole derivative compounds, compositions and uses
CN1780829B (zh) 2003-03-31 2010-12-29 惠氏公司 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物
EP2511267A1 (en) 2003-06-05 2012-10-17 Elan Pharmaceuticals Inc. 3-((n-acylated aminoacyl)amino)pyrazoles as inhibitors of beta-amyloid peptide production useful for the treatment of alzheimer's disease
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
DE602005016775D1 (de) 2004-01-16 2009-11-05 Wyeth Corp Heterocyclische, ein azol enthaltende sulfonamidinhibitoren der beta-amyloid-produktion
EP1725522B1 (en) 2004-03-03 2014-09-10 GlaxoSmithKline LLC Aniline derivatives as selective androgen receptor modulators
WO2006113552A2 (en) * 2005-04-15 2006-10-26 Smithkline Beecham Corporation Cyanoarylamines
CN100999546B (zh) * 2007-01-11 2010-08-11 清华大学 具有含氮杂环修饰的多肽类化合物及其应用
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
CN111777571B (zh) * 2020-06-28 2023-07-11 武汉药明康德新药开发有限公司 一种手性2-氨基-3 -(1,3-苯并噻唑-2-基)丙酸盐酸盐的合成方法

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KR100316865B1 (ko) * 1993-10-01 2002-11-29 메렐 파마슈티칼스 인크. 베타-아밀로이드단백질생성억제제
US6017887A (en) * 1995-01-06 2000-01-25 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors

Also Published As

Publication number Publication date
JP2001519769A (ja) 2001-10-23
WO1998022493A2 (en) 1998-05-28
NZ335157A (en) 2001-01-26
ID22275A (id) 1999-09-23
HUP0001383A3 (en) 2001-11-28
BR9714358A (pt) 2000-03-21
NO992426L (no) 1999-06-30
CA2270876A1 (en) 1998-05-28
NO992426D0 (no) 1999-05-20
AU5354398A (en) 1998-06-10
CN1237978A (zh) 1999-12-08
EP0942923A2 (en) 1999-09-22
HUP0001383A1 (hu) 2001-05-28
WO1998022493A3 (en) 1998-07-23
IL129477A0 (en) 2000-02-29

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