TR199802193T2 - Halo-Sübstitüe Edilmis Protein Kinaz C Inhibitörleri. - Google Patents

Halo-Sübstitüe Edilmis Protein Kinaz C Inhibitörleri.

Info

Publication number
TR199802193T2
TR199802193T2 TR1998/02193T TR9802193T TR199802193T2 TR 199802193 T2 TR199802193 T2 TR 199802193T2 TR 1998/02193 T TR1998/02193 T TR 1998/02193T TR 9802193 T TR9802193 T TR 9802193T TR 199802193 T2 TR199802193 T2 TR 199802193T2
Authority
TR
Turkey
Prior art keywords
protein kinase
halo
inhibitors
substituted protein
compounds
Prior art date
Application number
TR1998/02193T
Other languages
English (en)
Inventor
R. Jirousek Michael
G. Goekjian Peter
Wu Guo-Zhang
Original Assignee
Eli Lilly And Company
Mississippi State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company, Mississippi State University filed Critical Eli Lilly And Company
Publication of TR199802193T2 publication Critical patent/TR199802193T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Bulus formülü verilen yeni halo-ikameli bis-indolmaleimid bilesikleriyle ilgilidir.Bulus ayrica bu bilesiklerin elde edilmesinde kullanilan bir yöntem ve memelilerde protein kinaz C inhibisyonu için farmasötik formülasyonlar saglamaktadir.
TR1998/02193T 1996-05-01 1997-04-30 Halo-Sübstitüe Edilmis Protein Kinaz C Inhibitörleri. TR199802193T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1638296P 1996-05-01 1996-05-01

Publications (1)

Publication Number Publication Date
TR199802193T2 true TR199802193T2 (tr) 1999-02-22

Family

ID=21776838

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/02193T TR199802193T2 (tr) 1996-05-01 1997-04-30 Halo-Sübstitüe Edilmis Protein Kinaz C Inhibitörleri.

Country Status (21)

Country Link
US (1) US5936084A (tr)
EP (1) EP0805158B1 (tr)
JP (1) JP3235840B2 (tr)
KR (1) KR20000065137A (tr)
AT (1) ATE212026T1 (tr)
AU (1) AU703395B2 (tr)
BR (1) BR9709301A (tr)
CA (1) CA2252701C (tr)
CZ (1) CZ347098A3 (tr)
DE (1) DE69709568T2 (tr)
DK (1) DK0805158T3 (tr)
EA (1) EA001450B1 (tr)
ES (1) ES2170918T3 (tr)
IL (1) IL126762A0 (tr)
NO (1) NO310416B1 (tr)
NZ (1) NZ332658A (tr)
PL (1) PL329681A1 (tr)
PT (1) PT805158E (tr)
TR (1) TR199802193T2 (tr)
WO (1) WO1997041127A1 (tr)
YU (1) YU48398A (tr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127401A (en) * 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
US7425537B2 (en) * 2000-08-22 2008-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services SH2 domain binding inhibitors
ATE301661T1 (de) * 2000-12-08 2005-08-15 Ortho Mcneil Pharm Inc Makroheterocyclische verbindungen als kinase inhibitoren
MXPA04004026A (es) * 2001-10-29 2004-07-08 Nektar Therapeutics Al Corp Conjugados polimericos de inhibidores de la proteina quinasa c.
EP1542692B1 (en) 2002-05-22 2011-01-05 Amgen Inc. Aminopyrimidine derivatives for use as vanilloid receptor ligands for the treatment of pain
AU2003264047B2 (en) 2002-08-08 2008-06-26 Amgen Inc. Vanilloid receptor ligands and their use in treatments
DE10244453A1 (de) * 2002-09-24 2004-04-01 Phenomiques Gmbh Hemmung der Proteinkinase C-alpha zur Behandlung von Krankheiten
US7245117B1 (en) * 2004-11-01 2007-07-17 Cardiomems, Inc. Communicating with implanted wireless sensor
CA2556239A1 (en) 2004-02-11 2005-08-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments
MY139645A (en) 2004-02-11 2009-10-30 Amgen Inc Vanilloid receptor ligands and their use in treatments
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
BRPI0515279A (pt) 2004-09-14 2008-07-15 Pharmasset Inc preparação de ribofuranosil pirimidinas e purinas 2'fluoro-2'-alquil- substituìdas ou outras opcionalmente substituìdas e seus derivados
WO2006089311A1 (en) * 2005-02-15 2006-08-24 Amgen Inc. Vanilloid receptor ligands and their use in treatments
US8158586B2 (en) * 2005-04-11 2012-04-17 Pharmagap Inc. Inhibitors of protein kinases and uses thereof
EP1877400A1 (en) * 2005-04-15 2008-01-16 Amgen, Inc Vanilloid receptor ligands and their use in treatments
WO2010049947A2 (en) * 2008-10-28 2010-05-06 Accrete Pharmaceutical Private Limited Preparation of gemcitabine and intermediates thereof
HUE028278T2 (en) 2009-06-10 2016-12-28 Chugai Pharmaceutical Co Ltd Tetracyclic compound
BR112013003879B1 (pt) 2010-08-20 2020-12-22 Chugai Seiyaku Kabushiki Kaisha composição compreendendo compostos tetracíclicos e formulação oralmente administrável que a compreende
US10668075B2 (en) 2012-09-25 2020-06-02 Chugai Seiyaku Kabushiki Kaisha RET inhibitor
US10350214B2 (en) 2014-04-25 2019-07-16 Chugai Seiyaku Kabushiki Kaisha Preparation containing tetracyclic compound at high dose
EP3135671B1 (en) 2014-04-25 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Novel crystal of tetracyclic compound
TWI718102B (zh) 2014-08-08 2021-02-11 日商中外製藥股份有限公司 ４環性化合物的非晶質體
EP3246047A4 (en) 2015-01-16 2018-08-22 Chugai Seiyaku Kabushiki Kaisha Combination drug
WO2019000224A1 (zh) * 2017-06-27 2019-01-03 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途
US11939322B2 (en) 2018-09-04 2024-03-26 Chugai Seiyaku Kabushiki Kaisha Method for producing tetracyclic compound

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438050A (en) * 1988-02-06 1995-08-01 Godecke Aktiengesellschaft Indolocarbazole derivatives, processes for their preparation and compositions containing them
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5589472A (en) * 1992-09-25 1996-12-31 Vice; Susan F. Diindolo compounds and pharmaceutical compositions containing them
YU49200B (sh) * 1993-12-07 2004-09-03 Eli Lilly And Company Inhibitori proteinske kinaze c
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5472183A (en) * 1994-03-17 1995-12-05 Nisca Corporation Sheet feeding device with multiple sheet stackers
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5696949A (en) * 1995-06-15 1997-12-09 Intel Corporation System for PCI slots expansion using asynchronous PCI-to-PCI bridge with clock generator for providing clock signal to the expansion mother board and expansion side of bridge

Also Published As

Publication number Publication date
ATE212026T1 (de) 2002-02-15
US5936084A (en) 1999-08-10
ES2170918T3 (es) 2002-08-16
JPH11509233A (ja) 1999-08-17
EA199800966A1 (ru) 1999-04-29
EP0805158A2 (en) 1997-11-05
AU703395B2 (en) 1999-03-25
IL126762A0 (en) 1999-08-17
DE69709568D1 (de) 2002-02-21
EP0805158A3 (en) 1998-04-01
NO310416B1 (no) 2001-07-02
BR9709301A (pt) 1999-08-10
DK0805158T3 (da) 2002-03-18
CZ347098A3 (cs) 1999-06-16
EP0805158B1 (en) 2002-01-16
DE69709568T2 (de) 2002-09-05
EA001450B1 (ru) 2001-04-23
WO1997041127A1 (en) 1997-11-06
CA2252701C (en) 2003-10-28
AU2929297A (en) 1997-11-19
PT805158E (pt) 2002-06-28
NO985080L (no) 1998-12-08
YU48398A (sh) 2000-12-28
NZ332658A (en) 2000-05-26
PL329681A1 (en) 1999-04-12
KR20000065137A (ko) 2000-11-06
NO985080D0 (no) 1998-10-30
JP3235840B2 (ja) 2001-12-04
CA2252701A1 (en) 1997-11-06

Similar Documents

Publication Publication Date Title
TR199802193T2 (tr) Halo-Sübstitüe Edilmis Protein Kinaz C Inhibitörleri.
BR9404831A (pt) Composto,formulação farmacêutica e processo de preparação de um composto
PT95510A (pt) Processo de preparacao de pirimidina 4'-tionucleosidos e de composicoes farmaceuticas que os contem
PT918776E (pt) Sintese total de acilfulvenos antitumorais
TW371661B (en) Novel intermediates and their use to prepare N,N'-bridged bisindolylmaleimides
ES550817A0 (es) Procedimiento para preparar derivados de n-carboxialquil-2--oxo-3-diaril-5,6-triazinas
ATE135352T1 (de) 3-keto-hmg-coa reduktase-inhibitoren
FI964202A (fi) 5,6,7,8,9,10-heksahydro-8-hydroksi-5,8-dimetyyli-5,9-metanobentsosyklo-oktan-11-onijohdannaisia ja menetelmä niiden valmistamiseksi
DK0826663T3 (da) Alkynylaminosyrederivater og deres anvendelse som farmaceutiske forbindelser