TNSN90131A1 - Nouvelles fluoronaphthacenediones, leurs derives glycosyles et leurs procedes de fabrication - Google Patents

Nouvelles fluoronaphthacenediones, leurs derives glycosyles et leurs procedes de fabrication

Info

Publication number
TNSN90131A1
TNSN90131A1 TNTNSN90131A TNSN90131A TNSN90131A1 TN SN90131 A1 TNSN90131 A1 TN SN90131A1 TN TNSN90131 A TNTNSN90131 A TN TNSN90131A TN SN90131 A TNSN90131 A TN SN90131A TN SN90131 A1 TNSN90131 A1 TN SN90131A1
Authority
TN
Tunisia
Prior art keywords
fluoronaphthacenediones
novel
manufacturing methods
alpha
hydrogen atom
Prior art date
Application number
TNTNSN90131A
Other languages
English (en)
Inventor
Alessandro Giolitti
Antonio Guidi
Franco Pasqui
Vittorio Pestellini
Federico Arcamone
Original Assignee
Menarini Farma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT00956489A external-priority patent/IT1236322B/it
Priority claimed from IT9321A external-priority patent/IT1239017B/it
Priority claimed from IT9357A external-priority patent/IT1238673B/it
Application filed by Menarini Farma Ind filed Critical Menarini Farma Ind
Publication of TNSN90131A1 publication Critical patent/TNSN90131A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B35/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving a change in the type of bonding between two carbon atoms already directly linked
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C07D303/10—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals in which the oxirane rings are condensed with a carbocyclic ring system having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom

Abstract

DE NOUVEAUX COMPOSES HEPTASUSBTITUES FLUORO-2β -ACETYL-2α ,4α , 5, 12,-TETRAHYDROXY-1,2,3,4-TETRAHYDRO-6,11-NAPTHACENEDIONE POSSEDANT LA FORMULE GENERALE I. OU X EST UN ATOME D'HYDROGENE OU UN GROUPE HYDROXYLE, R ET R2, QUI NE PEUVENT ETRE LES MEMES, SONT UN ATOME D'HYDROGENE OU UN ATOME DE FLUOR ; R2 PEUT ETRE UN ATOME D'HYDROGENE OU UN GROUPE HYDROXYLE OU UN GROUPE ALKOXY. CES FLUORONAPHTHACENEDIONE PEUVENT ETRE UTILES DANS LA RECHERCHE DE NOUVEAUX DERIVES PRESENTANT UNE REACTIVITE DIFFERENTE AU NIVEAU DE L'HYDROXYLE 2ALPHA , EN PARTICULER DANS LA RECHERCHE DE NOUVELLES ANTHRACYCLINES
TNTNSN90131A 1989-11-13 1990-11-13 Nouvelles fluoronaphthacenediones, leurs derives glycosyles et leurs procedes de fabrication TNSN90131A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT00956489A IT1236322B (it) 1989-11-13 1989-11-13 8-fluoro-antracicline, relativi procedimenti di fabbricazione e loro uso.
IT9321A IT1239017B (it) 1990-02-20 1990-02-20 10-fluoro-antracicline, relativi procedimenti di fabbricazione e loro uso.
IT9357A IT1238673B (it) 1990-03-30 1990-03-30 8-fluoro-4-metossi-antracicline, relativi procedimenti di fabbricazione e loro uso.

Publications (1)

Publication Number Publication Date
TNSN90131A1 true TNSN90131A1 (fr) 1991-03-05

Family

ID=27272726

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN90131A TNSN90131A1 (fr) 1989-11-13 1990-11-13 Nouvelles fluoronaphthacenediones, leurs derives glycosyles et leurs procedes de fabrication

Country Status (24)

Country Link
EP (1) EP0436474B1 (fr)
JP (1) JPH03209343A (fr)
KR (1) KR940002983B1 (fr)
CN (1) CN1025608C (fr)
AT (1) ATE108760T1 (fr)
AU (1) AU641702B2 (fr)
BR (1) BR9005743A (fr)
CA (1) CA2029715A1 (fr)
CU (1) CU22303A3 (fr)
DE (1) DE69010874T2 (fr)
DK (1) DK0436474T3 (fr)
ES (1) ES2056433T3 (fr)
HU (1) HU208544B (fr)
IE (1) IE904002A1 (fr)
IL (1) IL96302A0 (fr)
LV (1) LV10422A (fr)
MA (1) MA21995A1 (fr)
NO (1) NO175101C (fr)
NZ (1) NZ236032A (fr)
PL (1) PL164019B1 (fr)
PT (1) PT95844B (fr)
RU (1) RU2015958C1 (fr)
TN (1) TNSN90131A1 (fr)
YU (1) YU47695B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3943029A1 (de) * 1989-12-27 1991-07-04 Behringwerke Ag Verfahren zur herstellung von glycosyl-anthracyclinonen
CA2121929A1 (fr) * 1994-04-22 1995-10-23 Pierre Doucet Moto reducteur
IT1271689B (it) * 1994-08-04 1997-06-04 Menarini Farma Ind 8-fluoro-antracicline, loro processi di preparazione e composizioni farmaceutiche che le contengono
WO1996016014A1 (fr) * 1994-11-22 1996-05-30 Novo Nordisk A/S Biocomposes actifs
WO1999058543A1 (fr) * 1998-05-13 1999-11-18 Instytut Farmaceutyczny Nouveaux derives n-alkyloxycarbonyliques de monosaccharides l-acosamine et l-daunosamine
KR100932407B1 (ko) * 2001-10-23 2009-12-17 다이닛본 스미토모 세이야꾸 가부시끼가이샤 염산 암루비신의 안정화
US7053191B2 (en) 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US8357785B2 (en) 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin
RU2766222C2 (ru) * 2017-12-26 2022-02-10 Общество с ограниченной ответственностью "НИАРМЕДИК ФАРМА" Несимметричные производные полифенолов динафталинового ряда, способ их получения и применение
CN114230538B (zh) * 2021-12-21 2023-11-17 蚌埠医学院 一种环系蒽醌类化合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8321676D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia 4'-haloanthrocycline glycosides
US4697005A (en) * 1985-03-20 1987-09-29 Ohio State University Research Foundation 1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics

Also Published As

Publication number Publication date
ES2056433T3 (es) 1994-10-01
EP0436474B1 (fr) 1994-07-20
LV10422A (lv) 1995-02-20
YU212390A (sh) 1992-12-21
YU47695B (sh) 1996-01-08
AU6596090A (en) 1991-07-11
PL287728A1 (en) 1992-11-02
JPH03209343A (ja) 1991-09-12
IL96302A0 (en) 1991-08-16
DE69010874T2 (de) 1994-11-10
EP0436474A1 (fr) 1991-07-10
PT95844A (pt) 1991-09-13
DK0436474T3 (da) 1994-08-29
NO175101B (no) 1994-05-24
AU641702B2 (en) 1993-09-30
NO904907D0 (no) 1990-11-12
CN1025608C (zh) 1994-08-10
ATE108760T1 (de) 1994-08-15
NO904907L (no) 1991-05-14
NO175101C (no) 1994-08-31
HU208544B (en) 1993-11-29
RU2015958C1 (ru) 1994-07-15
PL164019B1 (pl) 1994-06-30
KR910009613A (ko) 1991-06-28
KR940002983B1 (ko) 1994-04-09
CA2029715A1 (fr) 1991-05-14
CN1052659A (zh) 1991-07-03
MA21995A1 (fr) 1991-07-01
HUT55337A (en) 1991-05-28
CU22303A3 (es) 1995-01-31
NZ236032A (en) 1993-09-27
PT95844B (pt) 1997-11-28
IE904002A1 (en) 1991-05-22
BR9005743A (pt) 1991-09-24
DE69010874D1 (de) 1994-08-25

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