SU778711A3 - Способ получени 6а, 10а-транс-1окси-3-замещенных-6,6-диметил-6,6а 7,8,10,10а-гексагидро-9н-дибензо (в, )пиран-9-онов - Google Patents
Способ получени 6а, 10а-транс-1окси-3-замещенных-6,6-диметил-6,6а 7,8,10,10а-гексагидро-9н-дибензо (в, )пиран-9-онов Download PDFInfo
- Publication number
- SU778711A3 SU778711A3 SU772497361A SU2497361A SU778711A3 SU 778711 A3 SU778711 A3 SU 778711A3 SU 772497361 A SU772497361 A SU 772497361A SU 2497361 A SU2497361 A SU 2497361A SU 778711 A3 SU778711 A3 SU 778711A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- dimethyl
- hexahydro
- hydroxy
- dibenzo
- pyran
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 21
- 239000003960 organic solvent Substances 0.000 claims abstract description 4
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 14
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 2
- 150000008282 halocarbons Chemical class 0.000 claims description 2
- PUGUQINMNYINPK-UHFFFAOYSA-N tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCN(C(=O)CCl)CC1 PUGUQINMNYINPK-UHFFFAOYSA-N 0.000 claims description 2
- 229960004242 dronabinol Drugs 0.000 claims 1
- 238000006257 total synthesis reaction Methods 0.000 claims 1
- -1 aluminum halide Chemical class 0.000 abstract description 18
- 238000006243 chemical reaction Methods 0.000 abstract description 11
- 229910052782 aluminium Inorganic materials 0.000 abstract description 4
- 238000006345 epimerization reaction Methods 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- 239000002904 solvent Substances 0.000 description 11
- 238000004809 thin layer chromatography Methods 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- IBYHHJPAARCAIE-UHFFFAOYSA-N 1-bromo-2-chloroethane Chemical compound ClCCBr IBYHHJPAARCAIE-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 4
- 238000001704 evaporation Methods 0.000 description 4
- 230000008020 evaporation Effects 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- RFFLAFLAYFXFSW-UHFFFAOYSA-N 1,2-dichlorobenzene Chemical compound ClC1=CC=CC=C1Cl RFFLAFLAYFXFSW-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 2
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical compound O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- VOLMSPGWNYJHQQ-UHFFFAOYSA-N Pyranone Natural products CC1=C(O)C(=O)C(O)CO1 VOLMSPGWNYJHQQ-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 2
- PAAZPARNPHGIKF-UHFFFAOYSA-N 1,2-dibromoethane Chemical compound BrCCBr PAAZPARNPHGIKF-UHFFFAOYSA-N 0.000 description 1
- CYNYIHKIEHGYOZ-UHFFFAOYSA-N 1-bromopropane Chemical compound CCCBr CYNYIHKIEHGYOZ-UHFFFAOYSA-N 0.000 description 1
- IBSQPLPBRSHTTG-UHFFFAOYSA-N 1-chloro-2-methylbenzene Chemical compound CC1=CC=CC=C1Cl IBSQPLPBRSHTTG-UHFFFAOYSA-N 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- XOBKSJJDNFUZPF-UHFFFAOYSA-N Methoxyethane Chemical compound CCOC XOBKSJJDNFUZPF-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000005377 adsorption chromatography Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- ULYZAYCEDJDHCC-UHFFFAOYSA-N isopropyl chloride Chemical compound CC(C)Cl ULYZAYCEDJDHCC-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- PVWOIHVRPOBWPI-UHFFFAOYSA-N n-propyl iodide Chemical compound CCCI PVWOIHVRPOBWPI-UHFFFAOYSA-N 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/702,807 US4054582A (en) | 1976-07-06 | 1976-07-06 | Process for converting cis-hexahydrodibenzo[b,d]pyran-9-ones to trans-hexahydrodibenzo[b,d]-pyran-9-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU778711A3 true SU778711A3 (ru) | 1980-11-07 |
Family
ID=24822686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772497361A SU778711A3 (ru) | 1976-07-06 | 1977-06-04 | Способ получени 6а, 10а-транс-1окси-3-замещенных-6,6-диметил-6,6а 7,8,10,10а-гексагидро-9н-дибензо (в, )пиран-9-онов |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US4054582A (enExample) |
| JP (1) | JPS5943467B2 (enExample) |
| AR (1) | AR213965A1 (enExample) |
| AT (1) | AT351532B (enExample) |
| AU (1) | AU511626B2 (enExample) |
| BE (1) | BE856411A (enExample) |
| BG (1) | BG28060A3 (enExample) |
| CA (1) | CA1088082A (enExample) |
| CH (1) | CH633787A5 (enExample) |
| CS (1) | CS193581B2 (enExample) |
| DD (1) | DD131648A5 (enExample) |
| DE (1) | DE2729818C2 (enExample) |
| DK (1) | DK143401C (enExample) |
| ES (1) | ES460385A1 (enExample) |
| FR (1) | FR2357556A1 (enExample) |
| GB (1) | GB1582566A (enExample) |
| GR (1) | GR66429B (enExample) |
| HU (1) | HU176774B (enExample) |
| IE (1) | IE45245B1 (enExample) |
| IL (1) | IL52422A (enExample) |
| MX (1) | MX4952E (enExample) |
| MY (1) | MY8500786A (enExample) |
| NL (1) | NL7707460A (enExample) |
| NZ (1) | NZ184527A (enExample) |
| PH (1) | PH13925A (enExample) |
| PL (1) | PL104312B1 (enExample) |
| PT (1) | PT66745B (enExample) |
| RO (1) | RO72581A (enExample) |
| SE (1) | SE428019B (enExample) |
| SU (1) | SU778711A3 (enExample) |
| YU (1) | YU163577A (enExample) |
| ZA (1) | ZA773959B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1096390A (en) * | 1976-07-06 | 1981-02-24 | Edward R. Lavagnino | PROCESS FOR PREPARING DL-CIS-1-HYDROXY-3-SUBSTITUTED- 6,6-DIMETHYL-6,6.alpha.,7,8,10,10.alpha.-HEXAHYDRO-9H- DIBENZO(B,D,)PYRAN-9-ONES |
| US4395560A (en) * | 1982-05-24 | 1983-07-26 | Eli Lilly And Company | Preparation of 6a,10a-trans-hexahydrodibenzopyranones |
| JPS6067906U (ja) * | 1983-10-14 | 1985-05-14 | 株式会社 日立工機原町 | 自動鉋盤における送材速度可変機構 |
| US4861886A (en) * | 1987-07-10 | 1989-08-29 | Ishahara Sangyo Kaisha Ltd | Method for isomerization of trans-form 2-methylspiro (1,3-oxathiolane-5,3')q |
| US5498419A (en) * | 1994-06-03 | 1996-03-12 | Pars; Harry G. | Fumarate salt of 4-(diethyl-3-(1-methyloctyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol, 4-(diethyl-amino) butyric |
| ATE247097T1 (de) * | 1998-05-04 | 2003-08-15 | Univ Connecticut | Analgetische und immunomodulierende cannabinoiden |
| US7897598B2 (en) * | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
| US7589220B2 (en) * | 1998-06-09 | 2009-09-15 | University Of Connecticut | Inhibitors of the anandamide transporter |
| US7276613B1 (en) | 1998-11-24 | 2007-10-02 | University Of Connecticut | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
| US7161016B1 (en) | 1998-11-24 | 2007-01-09 | University Of Connecticut | Cannabimimetic lipid amides as useful medications |
| US8084467B2 (en) * | 1999-10-18 | 2011-12-27 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
| US7393842B2 (en) * | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
| US6943266B1 (en) * | 1999-10-18 | 2005-09-13 | University Of Connecticut | Bicyclic cannabinoid agonists for the cannabinoid receptor |
| DE60033834T2 (de) | 1999-10-18 | 2007-11-15 | The University Of Connecticut, Farmington | Für periphäre cannabinoid-rezeptoren selektive liganden |
| US7119108B1 (en) * | 1999-10-18 | 2006-10-10 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
| US6900236B1 (en) * | 1999-10-18 | 2005-05-31 | University Of Connecticut | Cannabimimetic indole derivatives |
| US7741365B2 (en) * | 1999-10-18 | 2010-06-22 | University Of Connecticut | Peripheral cannabinoid receptor (CB2) selective ligands |
| CA2435409A1 (en) * | 2001-01-26 | 2002-08-01 | University Of Connecticut | Novel cannabimimetic ligands |
| CA2436133A1 (en) | 2001-01-29 | 2002-08-08 | University Of Connecticut | Receptor selective cannabimimetic aminoalkylindoles |
| EP1414775B1 (en) * | 2001-07-13 | 2012-12-19 | The University of Connecticut | Bicyclic cannabinoid |
| US7666867B2 (en) * | 2001-10-26 | 2010-02-23 | University Of Connecticut | Heteroindanes: a new class of potent cannabimimetic ligands |
| WO2004017922A2 (en) | 2002-08-23 | 2004-03-04 | University Of Connecticut | Keto cannabinoids with therapeutic indications |
| ZA200802767B (en) * | 2005-09-29 | 2009-09-30 | Amr Technology Inc | Process for production of delta-9-tetrahydrocannabinol |
| CA2638940C (en) * | 2008-08-28 | 2009-09-15 | Dalton Chemical Laboratories Inc. | Improved synthesis of hexahydrodibenzopyranones |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
-
1976
- 1976-07-06 US US05/702,807 patent/US4054582A/en not_active Expired - Lifetime
-
1977
- 1977-06-04 SU SU772497361A patent/SU778711A3/ru active
- 1977-06-29 GB GB27151/77A patent/GB1582566A/en not_active Expired
- 1977-06-30 SE SE7707632A patent/SE428019B/xx not_active IP Right Cessation
- 1977-06-30 ZA ZA00773959A patent/ZA773959B/xx unknown
- 1977-06-30 NZ NZ184527A patent/NZ184527A/xx unknown
- 1977-06-30 PT PT66745A patent/PT66745B/pt unknown
- 1977-06-30 CA CA281,763A patent/CA1088082A/en not_active Expired
- 1977-06-30 PH PH19938A patent/PH13925A/en unknown
- 1977-06-30 IL IL52422A patent/IL52422A/xx unknown
- 1977-07-01 YU YU01635/77A patent/YU163577A/xx unknown
- 1977-07-01 AU AU26679/77A patent/AU511626B2/en not_active Expired
- 1977-07-01 DE DE2729818A patent/DE2729818C2/de not_active Expired
- 1977-07-01 BG BG036777A patent/BG28060A3/xx unknown
- 1977-07-04 JP JP52081487A patent/JPS5943467B2/ja not_active Expired
- 1977-07-04 ES ES460385A patent/ES460385A1/es not_active Expired
- 1977-07-04 AR AR268309A patent/AR213965A1/es active
- 1977-07-04 BE BE1008245A patent/BE856411A/xx not_active IP Right Cessation
- 1977-07-04 MX MX775870U patent/MX4952E/es unknown
- 1977-07-04 CH CH819277A patent/CH633787A5/de not_active IP Right Cessation
- 1977-07-04 PL PL1977199363A patent/PL104312B1/pl unknown
- 1977-07-05 NL NL7707460A patent/NL7707460A/xx not_active Application Discontinuation
- 1977-07-05 IE IE1387/77A patent/IE45245B1/en unknown
- 1977-07-05 DK DK301077A patent/DK143401C/da not_active IP Right Cessation
- 1977-07-05 DD DD7700199900A patent/DD131648A5/xx unknown
- 1977-07-05 RO RO7790930A patent/RO72581A/ro unknown
- 1977-07-05 HU HU77EI750A patent/HU176774B/hu unknown
- 1977-07-05 FR FR7720643A patent/FR2357556A1/fr active Granted
- 1977-07-05 GR GR53874A patent/GR66429B/el unknown
- 1977-07-06 CS CS774517A patent/CS193581B2/cs unknown
- 1977-07-06 AT AT483577A patent/AT351532B/de not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY786/85A patent/MY8500786A/xx unknown
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