SU76644A1 - Method for the production of water soluble derivative of gramicidin with - Google Patents
Method for the production of water soluble derivative of gramicidin withInfo
- Publication number
- SU76644A1 SU76644A1 SU381076A SU381076A SU76644A1 SU 76644 A1 SU76644 A1 SU 76644A1 SU 381076 A SU381076 A SU 381076A SU 381076 A SU381076 A SU 381076A SU 76644 A1 SU76644 A1 SU 76644A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- gramicidin
- production
- water soluble
- soluble derivative
- water
- Prior art date
Links
Description
Предлагаемый способ получени водорастворимого гргшпцидппа С заключаетс в метплировании последпего дпметплс льф-г ом в щелочной среде. Реакци производитс следуюпи1м образом. К 8-10 --кому раствору грамицидина в метиловом сппрте но капл м добавл етс диметилсульфат в количестве 6-7-кратпом по сравпеИ:11О с теоретически вычисленным количество.м, необходимым дли 11счерпываюн;его мет 5лировани грамицид 1на. Понеременно с днметплсульфатом но капл м добавл етс 8-Ш и-ный раствор едкого натра до Н1елочноп реакции по фенолфталеину. После добавлени реактивов смесь нагреваетс в течение 30 мин на вод ной бане с обратным холодильником. По окончании на1-реван-ии добавл етс щелочь до щелочной реакции и проводщ-е повторное метилирование на холоду. SaTeNr, реакционна емесь нагреваетс па вод ной бапе до кинени , охлаждаетс , добавл етс /з часть по объему воды и концентрированна сол на кислота до кислой реакции. В осадок выпадает метилированн1,1Й грамицидин. Осадок отфильтровываетс , промываетс несколько раз насыщенным раствором поваренной соли, затем небольщой порцией холодной воды и . Осадок высу1ниваетс на воздухе.The proposed method for the preparation of a water-soluble group is to mantle the subsequent process in an alkaline medium. The reaction is carried out in the following way. Dimethyl sulphate is added to a solution of gramicidin in a methyl spritter in an amount of 6–7-fold in 8–10 times: 11O with a theoretically calculated amount of m, necessary for 11 scypus, and it is grated 1 grams. Alternately with dimethylsulfate, 8-IH and a solution of caustic soda are added to the drops until the solid reaction with phenolphthalein is added. After the addition of the reagents, the mixture is heated for 30 minutes in a refluxed water bath. Upon termination of the 1-revan-i, alkali is added to the alkaline reaction and conductive re-methylation in the cold. SaTeNr, the reaction mixture is heated by a water vapor to kinen, cooled, a portion of the volume of water is added and concentrated hydrochloric acid is added to the acidic reaction. Methylated gramicidin precipitates. The precipitate is filtered off, washed several times with a saturated solution of sodium chloride, then with a small portion of cold water and. The precipitate is precipitated in air.
Л етилирова1шый грамицидин хорощо раствор етс в воде, обладает таким же антибиотическим действием как и иеходиый препарат, имеет в два раза меньшую токсичность и меньший ге.1ол1г-ическп1 уффект .Lethylirovanny gramicidin horosho dissolves in water, has the same antibiotic effect as the preparation, has two times less toxicity and less ge1ol1g-icchek effect.
Предмет изобретени Subject invention
Способ производства растворимого в воде нроизводного грамицидина С, от л и ч а ю щ и и с тем, что грамицидин С подвергают метилированию метилсульфатом до полного замещени водорода.Method for the production of water-soluble gramicidin C derivative, from l and h and n and so that gramicidin C is methylated by methyl sulfate to complete substitution of hydrogen.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU381076A SU76644A1 (en) | 1948-06-30 | 1948-06-30 | Method for the production of water soluble derivative of gramicidin with |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU381076A SU76644A1 (en) | 1948-06-30 | 1948-06-30 | Method for the production of water soluble derivative of gramicidin with |
Publications (1)
Publication Number | Publication Date |
---|---|
SU76644A1 true SU76644A1 (en) | 1975-03-25 |
Family
ID=20436514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU381076A SU76644A1 (en) | 1948-06-30 | 1948-06-30 | Method for the production of water soluble derivative of gramicidin with |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU76644A1 (en) |
-
1948
- 1948-06-30 SU SU381076A patent/SU76644A1/en active
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