SU548212A3 - Способ получени производных пирроло (3,4-в) пиразина или их солей - Google Patents
Способ получени производных пирроло (3,4-в) пиразина или их солейInfo
- Publication number
- SU548212A3 SU548212A3 SU1873290A SU1873290A SU548212A3 SU 548212 A3 SU548212 A3 SU 548212A3 SU 1873290 A SU1873290 A SU 1873290A SU 1873290 A SU1873290 A SU 1873290A SU 548212 A3 SU548212 A3 SU 548212A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- salts
- pyrazine derivatives
- mixture
- preparing pyrrolo
- solution
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title description 6
- HFDGGXUVSFYTLN-UHFFFAOYSA-N c1ncc2[nH]ccnc12 Chemical class c1ncc2[nH]ccnc12 HFDGGXUVSFYTLN-UHFFFAOYSA-N 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- 239000000203 mixture Substances 0.000 description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 2
- 150000001242 acetic acid derivatives Chemical class 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- KGRVJHAUYBGFFP-UHFFFAOYSA-N 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) Chemical compound CC(C)(C)C1=CC(C)=CC(CC=2C(=C(C=C(C)C=2)C(C)(C)C)O)=C1O KGRVJHAUYBGFFP-UHFFFAOYSA-N 0.000 description 1
- KKUKTXOBAWVSHC-UHFFFAOYSA-N Dimethylphosphate Chemical compound COP(O)(=O)OC KKUKTXOBAWVSHC-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 1
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 1
- 241000009298 Trigla lyra Species 0.000 description 1
- 101000956368 Trittame loki CRISP/Allergen/PR-1 Proteins 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000002152 aqueous-organic solution Substances 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 150000003949 imides Chemical class 0.000 description 1
- 229910052500 inorganic mineral Chemical class 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000011707 mineral Chemical class 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003216 pyrazines Chemical class 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7200505A FR2166314A1 (en) | 1972-01-07 | 1972-01-07 | 6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU548212A3 true SU548212A3 (ru) | 1977-02-25 |
Family
ID=9091606
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1873290A SU548212A3 (ru) | 1972-01-07 | 1973-01-05 | Способ получени производных пирроло (3,4-в) пиразина или их солей |
| SU1995434A SU504484A3 (ru) | 1972-01-07 | 1974-02-13 | Способ получени производных пирроло/3,4-в/ пиразина |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1995434A SU504484A3 (ru) | 1972-01-07 | 1974-02-13 | Способ получени производных пирроло/3,4-в/ пиразина |
Country Status (9)
| Country | Link |
|---|---|
| AR (1) | AR195635A1 (enExample) |
| CH (2) | CH564558A5 (enExample) |
| CS (2) | CS180610B2 (enExample) |
| ES (2) | ES410370A1 (enExample) |
| FR (1) | FR2166314A1 (enExample) |
| PL (2) | PL91759B1 (enExample) |
| SU (2) | SU548212A3 (enExample) |
| YU (2) | YU35597B (enExample) |
| ZA (1) | ZA7372B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2671800B1 (fr) * | 1991-01-17 | 1993-03-12 | Rhone Poulenc Rorer Sa | Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent. |
-
1972
- 1972-01-07 FR FR7200505A patent/FR2166314A1/fr active Granted
- 1972-12-28 PL PL1972174539A patent/PL91759B1/pl unknown
- 1972-12-28 PL PL1972159840A patent/PL82478B1/pl unknown
-
1973
- 1973-01-04 ZA ZA730072A patent/ZA7372B/xx unknown
- 1973-01-05 CH CH11373A patent/CH564558A5/xx not_active IP Right Cessation
- 1973-01-05 CS CS7300000122A patent/CS180610B2/cs unknown
- 1973-01-05 ES ES410370A patent/ES410370A1/es not_active Expired
- 1973-01-05 CH CH1160674A patent/CH560702A5/xx not_active IP Right Cessation
- 1973-01-05 SU SU1873290A patent/SU548212A3/ru active
- 1973-01-05 ES ES410371A patent/ES410371A1/es not_active Expired
- 1973-01-05 CS CSPV4995/76A patent/CS180649B1/cs unknown
- 1973-01-05 YU YU20/73A patent/YU35597B/xx unknown
- 1973-08-21 AR AR249661A patent/AR195635A1/es active
-
1974
- 1974-02-13 SU SU1995434A patent/SU504484A3/ru active
-
1979
- 1979-07-02 YU YU1595/79A patent/YU35888B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU2073A (en) | 1980-09-25 |
| ZA7372B (en) | 1973-09-26 |
| FR2166314A1 (en) | 1973-08-17 |
| SU504484A3 (ru) | 1976-02-25 |
| PL82478B1 (en) | 1975-10-31 |
| AR195635A1 (es) | 1973-10-23 |
| FR2166314B1 (enExample) | 1975-10-31 |
| YU35597B (en) | 1981-04-30 |
| PL91759B1 (en) | 1977-03-31 |
| ES410370A1 (es) | 1975-12-16 |
| CS180610B2 (en) | 1978-01-31 |
| CS180649B1 (en) | 1977-08-31 |
| ES410371A1 (es) | 1975-12-01 |
| CH560702A5 (enExample) | 1975-04-15 |
| YU35888B (en) | 1981-08-31 |
| CH564558A5 (enExample) | 1975-07-31 |
| YU159579A (en) | 1980-12-31 |
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