SU526295A3 - Способ получени -лизина - Google Patents
Способ получени -лизинаInfo
- Publication number
- SU526295A3 SU526295A3 SU1912978A SU1912978A SU526295A3 SU 526295 A3 SU526295 A3 SU 526295A3 SU 1912978 A SU1912978 A SU 1912978A SU 1912978 A SU1912978 A SU 1912978A SU 526295 A3 SU526295 A3 SU 526295A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- ferm
- medium
- lysine
- fermentation
- strain
- Prior art date
Links
- 239000004472 Lysine Substances 0.000 title claims 17
- 238000004519 manufacturing process Methods 0.000 title claims 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title claims 3
- 239000002609 medium Substances 0.000 claims 54
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 33
- 238000000855 fermentation Methods 0.000 claims 30
- 230000004151 fermentation Effects 0.000 claims 30
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 27
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 21
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 16
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 14
- 239000003531 protein hydrolysate Substances 0.000 claims 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 12
- 235000010469 Glycine max Nutrition 0.000 claims 12
- 244000068988 Glycine max Species 0.000 claims 12
- 239000008103 glucose Substances 0.000 claims 12
- 235000019766 L-Lysine Nutrition 0.000 claims 11
- 235000015097 nutrients Nutrition 0.000 claims 11
- 229960002685 biotin Drugs 0.000 claims 10
- 235000020958 biotin Nutrition 0.000 claims 10
- 239000011616 biotin Substances 0.000 claims 10
- 150000002500 ions Chemical class 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims 8
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 8
- 239000004202 carbamide Substances 0.000 claims 7
- 238000003756 stirring Methods 0.000 claims 7
- 235000019157 thiamine Nutrition 0.000 claims 7
- 239000011721 thiamine Substances 0.000 claims 7
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims 7
- 229960000344 thiamine hydrochloride Drugs 0.000 claims 7
- 235000019190 thiamine hydrochloride Nutrition 0.000 claims 7
- 239000011747 thiamine hydrochloride Substances 0.000 claims 7
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims 6
- 239000005695 Ammonium acetate Substances 0.000 claims 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 6
- 229940043376 ammonium acetate Drugs 0.000 claims 6
- 235000019257 ammonium acetate Nutrition 0.000 claims 6
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 claims 6
- 229960003495 thiamine Drugs 0.000 claims 6
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims 6
- 150000008545 L-lysines Chemical class 0.000 claims 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 4
- 239000002054 inoculum Substances 0.000 claims 4
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims 3
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 claims 3
- 238000005273 aeration Methods 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 229940024606 amino acid Drugs 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 229940041514 candida albicans extract Drugs 0.000 claims 3
- 239000012531 culture fluid Substances 0.000 claims 3
- 238000004817 gas chromatography Methods 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 235000019161 pantothenic acid Nutrition 0.000 claims 3
- 239000011713 pantothenic acid Substances 0.000 claims 3
- 229940055726 pantothenic acid Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012138 yeast extract Substances 0.000 claims 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 2
- WTLKTXIHIHFSGU-UHFFFAOYSA-N 2-nitrosoguanidine Chemical compound NC(N)=NN=O WTLKTXIHIHFSGU-UHFFFAOYSA-N 0.000 claims 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 2
- 229930024421 Adenine Natural products 0.000 claims 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- 108010073771 Soybean Proteins Proteins 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 229930003270 Vitamin B Natural products 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229960000643 adenine Drugs 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 229960003767 alanine Drugs 0.000 claims 2
- 235000011114 ammonium hydroxide Nutrition 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 239000003729 cation exchange resin Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000000284 extract Substances 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 235000018977 lysine Nutrition 0.000 claims 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 239000005445 natural material Substances 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 229960002429 proline Drugs 0.000 claims 2
- 235000019710 soybean protein Nutrition 0.000 claims 2
- 230000001954 sterilising effect Effects 0.000 claims 2
- 238000004659 sterilization and disinfection Methods 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 235000019156 vitamin B Nutrition 0.000 claims 2
- 239000011720 vitamin B Substances 0.000 claims 2
- YERMBKYNILMCNC-UXHICEINSA-N (1s,2s)-n-[4-(benzenesulfonyl)phenyl]-2-pyridin-3-ylcyclopropane-1-carboxamide Chemical compound O=C([C@@H]1[C@H](C1)C=1C=NC=CC=1)NC(C=C1)=CC=C1S(=O)(=O)C1=CC=CC=C1 YERMBKYNILMCNC-UXHICEINSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 claims 1
- -1 2 mg% Chemical class 0.000 claims 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 241000928106 Alain Species 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- GHSJKUNUIHUPDF-BYPYZUCNSA-N L-thialysine Chemical compound NCCSC[C@H](N)C(O)=O GHSJKUNUIHUPDF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 108010048581 Lysine decarboxylase Proteins 0.000 claims 1
- 239000001888 Peptone Substances 0.000 claims 1
- 108010080698 Peptones Proteins 0.000 claims 1
- 229920006172 Tetrafluoroethylene propylene Polymers 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 1
- 235000011130 ammonium sulphate Nutrition 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000007664 blowing Methods 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- FAPWYRCQGJNNSJ-CTWWJBIBSA-L calcium;3-[[(2s)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate Chemical compound [Ca+2].OCC(C)(C)[C@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-CTWWJBIBSA-L 0.000 claims 1
- 239000005018 casein Substances 0.000 claims 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
- 235000021240 caseins Nutrition 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000007796 conventional method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 claims 1
- 238000005516 engineering process Methods 0.000 claims 1
- 235000020774 essential nutrients Nutrition 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 210000003746 feather Anatomy 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 238000003475 lamination Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 230000002906 microbiologic effect Effects 0.000 claims 1
- 238000013048 microbiological method Methods 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 238000004816 paper chromatography Methods 0.000 claims 1
- 235000019319 peptone Nutrition 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 235000013930 proline Nutrition 0.000 claims 1
- 238000012958 reprocessing Methods 0.000 claims 1
- 238000011218 seed culture Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 claims 1
- 229960002898 threonine Drugs 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 239000000052 vinegar Substances 0.000 claims 1
- 235000021419 vinegar Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP47042527A JPS491794A (enrdf_load_stackoverflow) | 1972-04-27 | 1972-04-27 | |
| JP8264172A JPS4936888A (enrdf_load_stackoverflow) | 1972-08-18 | 1972-08-18 | |
| JP9403072A JPS561078B2 (enrdf_load_stackoverflow) | 1972-09-19 | 1972-09-19 | |
| JP12024772A JPS551040B2 (enrdf_load_stackoverflow) | 1972-11-30 | 1972-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU526295A3 true SU526295A3 (ru) | 1976-08-25 |
Family
ID=27461211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1912978A SU526295A3 (ru) | 1972-04-27 | 1973-04-26 | Способ получени -лизина |
Country Status (11)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1916308A1 (en) * | 2006-10-26 | 2008-04-30 | DSMIP Assets B.V. | Use of vitamins in fermentation processes for the production of amino acids |
| CN110885863A (zh) * | 2019-12-01 | 2020-03-17 | 齐齐哈尔龙江阜丰生物科技有限公司 | 利用菌体蛋白制备赖氨酸发酵培养基的方法 |
-
1973
- 1973-04-24 SE SE7305740A patent/SE410978B/xx unknown
- 1973-04-24 CS CS293173A patent/CS182785B2/cs unknown
- 1973-04-26 CH CH600873A patent/CH574501A5/xx not_active IP Right Cessation
- 1973-04-26 BG BG023447A patent/BG24960A3/xx unknown
- 1973-04-26 NL NL7305828A patent/NL175197C/xx not_active IP Right Cessation
- 1973-04-26 DK DK228973A patent/DK134570B/da not_active IP Right Cessation
- 1973-04-26 HU HUAI000226 patent/HU172604B/hu unknown
- 1973-04-26 SU SU1912978A patent/SU526295A3/ru active
- 1973-04-27 GB GB2014973A patent/GB1430842A/en not_active Expired
- 1973-04-27 CA CA170,007A patent/CA995163A/en not_active Expired
- 1973-04-27 FR FR7315472A patent/FR2182211B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HU172604B (en) | 1977-11-28 |
| NL7305828A (enrdf_load_stackoverflow) | 1973-10-30 |
| DK134570B (da) | 1976-11-29 |
| SE410978B (sv) | 1979-11-19 |
| CA995163A (en) | 1976-08-17 |
| DE2321461A1 (de) | 1973-11-08 |
| FR2182211B1 (enrdf_load_stackoverflow) | 1976-06-11 |
| CH574501A5 (enrdf_load_stackoverflow) | 1976-04-15 |
| DK134570C (enrdf_load_stackoverflow) | 1977-05-02 |
| NL175197B (nl) | 1984-05-01 |
| NL175197C (nl) | 1984-10-01 |
| FR2182211A1 (enrdf_load_stackoverflow) | 1973-12-07 |
| GB1430842A (en) | 1976-04-07 |
| DE2321461B2 (de) | 1975-06-19 |
| CS182785B2 (en) | 1978-05-31 |
| AU5463773A (en) | 1974-10-24 |
| BG24960A3 (en) | 1978-06-15 |
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