SU505364A3 - The method of obtaining derivatives of 4n-benzo (4,5) c of clogpeta (1,2-v) triofen - Google Patents

The method of obtaining derivatives of 4n-benzo (4,5) c of clogpeta (1,2-v) triofen

Info

Publication number
SU505364A3
SU505364A3 SU2027852A SU2027852A SU505364A3 SU 505364 A3 SU505364 A3 SU 505364A3 SU 2027852 A SU2027852 A SU 2027852A SU 2027852 A SU2027852 A SU 2027852A SU 505364 A3 SU505364 A3 SU 505364A3
Authority
SU
USSR - Soviet Union
Prior art keywords
benzo
triofen
clogpeta
obtaining derivatives
derivatives
Prior art date
Application number
SU2027852A
Other languages
Russian (ru)
Inventor
Буркин Жан-Пьер
Шварб Густав
Вальдфогель Эрвин
Original Assignee
Сандос Аг (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сандос Аг (Фирма) filed Critical Сандос Аг (Фирма)
Application granted granted Critical
Publication of SU505364A3 publication Critical patent/SU505364A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

(54) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 4Н-БЕНЗО(4,5)ЦИКЛОГЕПТА(1,2-Ь)ТИОФЕНА(54) METHOD FOR OBTAINING 4H-BENZO DERIVATIVES (4,5) CYCLOHEPT (1,2-b) TIOPHENE

1one

Изобретение относитс  IK способу получени  неописанных в литературе производных 4Нбензо (4,5)циклогептан(1,2 -Ь)тиофена общей формулыThis invention relates to an IK method for the preparation of 4Nbenzo (4,5) cycloheptane (1,2-b) thiophene derivatives not described in the literature.

ТОНTONE

или их солей,or their salts,

где RI - водород или наход щийс  в положении 6 или 7 галоид, в частности хлор или брам или низший алкоксиостато,к;where RI is hydrogen or halogen in position 6 or 7, in particular chlorine or bram or lower alkoxystato, k;

R2- низший алкил или бензильна  или дифенилметильна  группа, причем фи ильные группы могут содержать галоген, в частности хлор, фтор или бром;R2 is lower alkyl or benzyl or diphenylmethyl group, and the phiyl groups may contain halogen, in particular chlorine, fluorine or bromine;

если RI - низша  алкоксигруппа и/или RS - низша  аЛКильна  групла, то они, в частности, содержат 1-4 атома }тлерода;if RI is a lower alkoxy group and / or RS is a lower alkyl group, in particular, they contain 1–4 atoms} of hydrogen;

гидроксииминогруппа находитс  в положении 9 или 10.the hydroxy amino group is in position 9 or 10.

Известен способ получени  соединени  общей формулы:A known method for producing a compound of the general formula:

10ten

где RI - водород или наход щийс  в положении 6 или 7 галоид, или низший алкоксильный остаток;where RI is hydrogen or halogen in position 6 or 7, or a lower alkoxy residue;

R2 - низщий алкил,R2 is lower alkyl,

путем гидролиза и дигидратации соединени  формулы:by hydrolysis and dihydration of a compound of the formula:

2020

2525

SU2027852A 1972-01-24 1974-05-28 The method of obtaining derivatives of 4n-benzo (4,5) c of clogpeta (1,2-v) triofen SU505364A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH98872A CH565172A5 (en) 1972-01-24 1972-01-24 4-piperidylidene benzocycloheptathiophenes - - antihistamines and serotonin and acetyl choline inhibitors

Publications (1)

Publication Number Publication Date
SU505364A3 true SU505364A3 (en) 1976-02-28

Family

ID=4199855

Family Applications (1)

Application Number Title Priority Date Filing Date
SU2027852A SU505364A3 (en) 1972-01-24 1974-05-28 The method of obtaining derivatives of 4n-benzo (4,5) c of clogpeta (1,2-v) triofen

Country Status (6)

Country Link
CH (1) CH565172A5 (en)
CS (1) CS180000B2 (en)
DK (1) DK134405B (en)
ES (1) ES438596A1 (en)
PL (1) PL92124B1 (en)
SU (1) SU505364A3 (en)

Also Published As

Publication number Publication date
DK134405C (en) 1977-03-28
CH565172A5 (en) 1975-08-15
PL92124B1 (en) 1977-03-31
ES438596A1 (en) 1977-09-01
DK134405B (en) 1976-11-01
CS180000B2 (en) 1977-12-30

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