SU503520A3 - Способ получени производных бензодиазепина - Google Patents
Способ получени производных бензодиазепинаInfo
- Publication number
- SU503520A3 SU503520A3 SU2046326A SU2046326A SU503520A3 SU 503520 A3 SU503520 A3 SU 503520A3 SU 2046326 A SU2046326 A SU 2046326A SU 2046326 A SU2046326 A SU 2046326A SU 503520 A3 SU503520 A3 SU 503520A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- carbon atoms
- chlorine
- substituted
- general formula
- alkyl radical
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 6
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- 229910052801 chlorine Inorganic materials 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 125000004423 acyloxy group Chemical group 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- WBLXMRIMSGHSAC-UHFFFAOYSA-N [Cl].[Cl] Chemical compound [Cl].[Cl] WBLXMRIMSGHSAC-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- 239000000460 chlorine Substances 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical class N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 2
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- -1 carboxylic acid chlorides Chemical class 0.000 description 2
- 238000005886 esterification reaction Methods 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229940014800 succinic anhydride Drugs 0.000 description 2
- ZVAPWJGRRUHKGP-UHFFFAOYSA-N 1h-1,5-benzodiazepine Chemical compound N1C=CC=NC2=CC=CC=C12 ZVAPWJGRRUHKGP-UHFFFAOYSA-N 0.000 description 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000006266 etherification reaction Methods 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702052841 DE2052841A1 (de) | 1970-10-28 | 1970-10-28 | Benzodiazepinderivate |
| DE19712133065 DE2133065A1 (de) | 1971-07-02 | 1971-07-02 | Benzodiazepinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU503520A3 true SU503520A3 (ru) | 1976-02-15 |
Family
ID=25759978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU2046326A SU503520A3 (ru) | 1970-10-28 | 1974-07-18 | Способ получени производных бензодиазепина |
Country Status (11)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6022359U (ja) * | 1983-07-20 | 1985-02-15 | 株式会社 ほういち | ヘツド移行式印字機の印字スケ−ル |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5031158A (enrdf_load_stackoverflow) * | 1973-07-21 | 1975-03-27 |
-
1971
- 1971-10-13 AR AR23844971A patent/AR193978A1/es active
- 1971-10-13 YU YU260371A patent/YU34478B/xx unknown
- 1971-10-22 CS CS743671A patent/CS161139B2/cs unknown
- 1971-10-26 ES ES396392A patent/ES396392A1/es not_active Expired
- 1971-10-27 CA CA126275A patent/CA918661A/en not_active Expired
- 1971-10-27 NL NL7114819A patent/NL7114819A/xx not_active Application Discontinuation
- 1971-10-27 JP JP8546271A patent/JPS5619347B1/ja active Pending
- 1971-10-27 AT AT928771A patent/AT313280B/de active
- 1971-10-27 SE SE1364471A patent/SE389111B/xx unknown
- 1971-10-27 CH CH1566471A patent/CH555835A/de not_active IP Right Cessation
-
1974
- 1974-07-18 SU SU2046326A patent/SU503520A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| CS161139B2 (enrdf_load_stackoverflow) | 1975-05-04 |
| YU260371A (en) | 1979-02-28 |
| CA918661A (en) | 1973-01-09 |
| ES396392A1 (es) | 1974-11-01 |
| AR193978A1 (es) | 1973-06-12 |
| SE389111B (sv) | 1976-10-25 |
| CH555835A (de) | 1974-11-15 |
| JPS5619347B1 (enrdf_load_stackoverflow) | 1981-05-07 |
| NL7114819A (enrdf_load_stackoverflow) | 1972-05-03 |
| YU34478B (en) | 1979-09-10 |
| AT313280B (de) | 1974-02-11 |
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