SU470964A3 - Способ получени антибиотика - Google Patents
Способ получени антибиотикаInfo
- Publication number
- SU470964A3 SU470964A3 SU1739199A SU1739199A SU470964A3 SU 470964 A3 SU470964 A3 SU 470964A3 SU 1739199 A SU1739199 A SU 1739199A SU 1739199 A SU1739199 A SU 1739199A SU 470964 A3 SU470964 A3 SU 470964A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- medium
- antibiotic
- chloroform
- mycelium
- agar
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title description 11
- 238000000034 method Methods 0.000 title description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 34
- 239000002609 medium Substances 0.000 description 20
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 16
- 239000000203 mixture Substances 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 229920001817 Agar Polymers 0.000 description 8
- 239000008272 agar Substances 0.000 description 8
- 235000010419 agar Nutrition 0.000 description 8
- 239000000049 pigment Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000000758 substrate Substances 0.000 description 7
- HELPZWNRUYNCJQ-QWJSOBSRSA-N (e)-3-[4-[(5z)-3,4-dihydroxy-5-[2-(3-hydroxy-4,5-dimethoxy-6-methyloxan-2-yl)oxy-1-methoxyethylidene]oxolan-2-yl]oxyphenyl]-n-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-2-methylprop-2-enamide Chemical compound OC1C(OC)C(OC)C(C)OC1OC\C(OC)=C\1C(O)C(O)C(OC=2C=CC(\C=C(/C)C(=O)NC3C(C(OC3CO)N3C4=NC=NC(=C4N=C3)N(C)C)O)=CC=2)O/1 HELPZWNRUYNCJQ-QWJSOBSRSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000000741 silica gel Substances 0.000 description 5
- 229910002027 silica gel Inorganic materials 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940041514 candida albicans extract Drugs 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000003208 petroleum Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000012138 yeast extract Substances 0.000 description 3
- 102100027211 Albumin Human genes 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 241000936887 Saccharothrix mutabilis subsp. capreolus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000187747 Streptomyces Species 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- 230000008033 biological extinction Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 239000012531 culture fluid Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 229910052500 inorganic mineral Chemical class 0.000 description 2
- 239000011707 mineral Chemical class 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241001237963 Amanita flavoconia Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000282988 Capreolus Species 0.000 description 1
- 241000723418 Carya Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003254 anti-foaming effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000002026 chloroform extract Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 238000004452 microanalysis Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 239000013587 production medium Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00188058A US3843784A (en) | 1970-12-24 | 1971-10-12 | Antibiotics a201a and a201b and process for the production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU470964A3 true SU470964A3 (ru) | 1975-05-15 |
Family
ID=22691630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1739199A SU470964A3 (ru) | 1971-10-12 | 1972-01-21 | Способ получени антибиотика |
Country Status (3)
| Country | Link |
|---|---|
| HU (1) | HU163865B (enrdf_load_html_response) |
| PL (1) | PL82898B1 (enrdf_load_html_response) |
| SU (1) | SU470964A3 (enrdf_load_html_response) |
-
1971
- 1971-12-29 PL PL15255671A patent/PL82898B1/pl unknown
-
1972
- 1972-01-04 HU HUEI000399 patent/HU163865B/hu unknown
- 1972-01-21 SU SU1739199A patent/SU470964A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| PL82898B1 (enrdf_load_html_response) | 1975-10-31 |
| HU163865B (enrdf_load_html_response) | 1973-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0170006A2 (en) | Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents | |
| CA1338185C (en) | Glycosidase inhibitor salbostatin, process for its preparation, and its use | |
| SU1071226A3 (ru) | Способ получени антибиотической смеси | |
| JPH0341475B2 (enrdf_load_html_response) | ||
| AU603271B2 (en) | Derivatives of paraherquamide isolated from a fermentation broth active as antiparasitic agents | |
| SU470964A3 (ru) | Способ получени антибиотика | |
| SU442605A1 (ru) | Способ получени антибиотика | |
| CN114982763B (zh) | 格尔德霉素及其类似物的新用途 | |
| US4869901A (en) | Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents | |
| SU751332A3 (ru) | Способ получени антибиотического комплекса а-35512 | |
| US2657170A (en) | Antimycin and process for production | |
| US4670260A (en) | Antibiotic for animal feeds | |
| AU657011B2 (en) | Antibiotic AB-041 and the process for its production | |
| JPH0740950B2 (ja) | 微生物によるニコチアナミンの製造法 | |
| EP0074849A1 (en) | A-32724 antibiotics and process for production thereof | |
| SU632307A3 (ru) | Способ получени полипептидного антибиотического комплекса, обладающего противогрибковой активностью | |
| EP0259778B1 (de) | Antibiotisch wirksames Gentisinsäurederivat | |
| JPS6317834B2 (enrdf_load_html_response) | ||
| GB1583408A (en) | Antibiotic x-14547 | |
| FR2476128A1 (fr) | Procede microbiologique de production de narasine et cultures contenant le microorganisme producteur streptomyces lydicus deboer et al- | |
| SU1760986A3 (ru) | Способ получени 4 @ -дезокси-13(S)-дигидро-4 @ -йододоксорубицина | |
| JPH0515385A (ja) | 新規な抗生物質アリサマイシンおよびその製法 | |
| JPS6015318B2 (ja) | 新抗生物質ｓｆ−１９４２物質，その製造法およびそれを含有する抗ガン剤 | |
| SU884575A3 (ru) | Способ получени антибиотического комплекса | |
| JP2780828B2 (ja) | ポリエーテル抗生物質ｍｉ２１５―ｎｆ３物質及びその製造法、並びに鶏のコクシジウム症の防除剤 |