SU371941A1 - - Google Patents

Info

Publication number

SU371941A1

SU371941A1 SU1660014A SU1660014A SU371941A1 SU 371941 A1 SU371941 A1 SU 371941A1 SU 1660014 A SU1660014 A SU 1660014A SU 1660014 A SU1660014 A SU 1660014A SU 371941 A1 SU371941 A1 SU 371941A1

Authority

SU

USSR - Soviet Union

Prior art keywords

solution

chloroform

treated

extract

mixture

Prior art date

1971-05-19

Links

• Espacenet
• Global Dossier
• Discuss

• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 16
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
• 238000000034 method Methods 0.000 description 6
• 239000000203 mixture Substances 0.000 description 6
• 229930013930 alkaloid Natural products 0.000 description 5
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
• IYLRRIUNGGQRTN-UHFFFAOYSA-N Kopsinin Natural products C12=CC=CC=C2NC2(CC3)C(C(=O)OC)CC43C3C21CCN3CCC4 IYLRRIUNGGQRTN-UHFFFAOYSA-N 0.000 description 3
• 241000863480 Vinca Species 0.000 description 3
• 150000002823 nitrates Chemical class 0.000 description 3
• 239000002994 raw material Substances 0.000 description 3
• FZLISVGXWLVEPB-UHFFFAOYSA-N 10-hydroxycanthin-6-one Chemical compound C1=CC(=O)N2C3=CC=C(O)C=C3C3=CC=NC1=C32 FZLISVGXWLVEPB-UHFFFAOYSA-N 0.000 description 2
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
• 229910002651 NO3 Inorganic materials 0.000 description 2
• NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
• GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
• 230000001476 alcoholic effect Effects 0.000 description 2
• 238000006243 chemical reaction Methods 0.000 description 2
• 238000000605 extraction Methods 0.000 description 2
• 229910017604 nitric acid Inorganic materials 0.000 description 2
• 238000002360 preparation method Methods 0.000 description 2
• 239000000047 product Substances 0.000 description 2
• 238000001953 recrystallisation Methods 0.000 description 2
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
• VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
• AJNGZYCQTIEETH-UHFFFAOYSA-N C=CO.[Cl] Chemical compound C=CO.[Cl] AJNGZYCQTIEETH-UHFFFAOYSA-N 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• -1 alkaloid salts Chemical class 0.000 description 1
• 235000011114 ammonium hydroxide Nutrition 0.000 description 1
• 239000002269 analeptic agent Substances 0.000 description 1
• 230000003555 analeptic effect Effects 0.000 description 1
• 210000003169 central nervous system Anatomy 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 150000001860 citric acid derivatives Chemical class 0.000 description 1
• 238000001816 cooling Methods 0.000 description 1
• 239000013078 crystal Substances 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• DRNBLNIUGKCELA-UHFFFAOYSA-N ethenol hydrochloride Chemical compound C=CO.Cl DRNBLNIUGKCELA-UHFFFAOYSA-N 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 238000000622 liquid--liquid extraction Methods 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 238000012856 packing Methods 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• CZLWGXKWXLVFJU-UHFFFAOYSA-N pseudocopsinine Natural products C12=CC=CC=C2NC2(C3C)C(C(=O)OC)CC43C3C21CCN3CCC4 CZLWGXKWXLVFJU-UHFFFAOYSA-N 0.000 description 1
• ZLQMRLSBXKQKMG-UHFFFAOYSA-N rauniticine Natural products COC(=O)C1=CC2CC3N(CCc4c3[nH]c5ccccc45)CC2C(C)O1 ZLQMRLSBXKQKMG-UHFFFAOYSA-N 0.000 description 1
• 238000000638 solvent extraction Methods 0.000 description 1