SU255285A1 - - Google Patents
Info
- Publication number
- SU255285A1 SU255285A1 SU1273837A SU1273837A SU255285A1 SU 255285 A1 SU255285 A1 SU 255285A1 SU 1273837 A SU1273837 A SU 1273837A SU 1273837 A SU1273837 A SU 1273837A SU 255285 A1 SU255285 A1 SU 255285A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- tripyryl
- pyrrolkali
- triazine
- tetrahydrofuran
- pyrrole
- Prior art date
Links
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 8
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- -1 alkali metal salt Chemical class 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- KAESVJOAVNADME-UHFFFAOYSA-N pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- MGNCLNQXLYJVJD-UHFFFAOYSA-N Cyanuric chloride Chemical compound ClC1=NC(Cl)=NC(Cl)=N1 MGNCLNQXLYJVJD-UHFFFAOYSA-N 0.000 description 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- ZFSLODLOARCGLH-UHFFFAOYSA-N Cyanuric acid Chemical compound OC1=NC(O)=NC(O)=N1 ZFSLODLOARCGLH-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- XTLNYNMNUCLWEZ-UHFFFAOYSA-N ethanol;propan-2-one Chemical compound CCO.CC(C)=O XTLNYNMNUCLWEZ-UHFFFAOYSA-N 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000005020 pharmaceutical industry Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing Effects 0.000 description 1
Description
Изобретение относитс к области получени новой системы соединений, которые могут найти применение в фармацевтической промышленности в качестве полупродуктов дл синтеза красителей.The invention relates to the field of obtaining a new system of compounds that can be used in the pharmaceutical industry as intermediates for the synthesis of dyes.
Предлагаемый способ получени 2,4,6-трипиррил-5-триазина заключаетс в том, что цианурхло ид подвергают взаимодействию с солью щелочного металла пиррола, например пирролкалием, в среде органического растворител , например тетрагидрофурана, преимуществ енно при температуре 15-25°С. Продукты выдел ют известным способом. Выход около 620/0Пример . К раствору 26,2 г (0,250 лоль) пирролкали в 100 мл тетрагидрофурана, помещенному в колбу с обратным холодильником , мешалкой и термометром, при 15-25°С приливают раствор 15 г цианурхлорида в 150 мл, тетрагидрофурана.The proposed method for the preparation of 2,4,6-tripyryl-5-triazine is that the cyanuric acid is reacted with an alkali metal salt of pyrrole, for example pyrrolkali, in an organic solvent medium, for example tetrahydrofuran, preferably at a temperature of 15-25 ° C. Products are isolated in a known manner. Output about 620/0 Example. To a solution of 26.2 g (0.250 L) of pyrrolkali in 100 ml of tetrahydrofuran, placed in a flask with reflux condenser, a stirrer and a thermometer, a solution of 15 g of cyanuric chloride in 150 ml of tetrahydrofuran is poured at 15-25 ° C.
Конденсацию провод т при 15-25°С в токе азота при хорошем перемешивании в течение 18 час.The condensation is carried out at 15-25 ° C in a stream of nitrogen with good stirring for 18 hours.
После выдержки смесь выливают в воду. Выпавший продукт отфильтровывают, хорошо промывают водой и сушат.After aging the mixture is poured into water. The precipitated product is filtered off, washed well with water and dried.
После перекристаллизации из смеси ацетон - этанол {80 : 20) выход продукта 13,9 г, т. е. 62% от цианурхлорида.After recrystallization from a mixture of acetone - ethanol {80: 20), the product yield is 13.9 g, i.e. 62% of cyanuric chloride.
Полученный 2,4,6-трипиррил-5-триазин с т. пл. 183°С представл ет собой белые игольчатые кристаллы. Хорошо раствор етс в ацетоне , диметилформамиде, плохо - в этаноле и «е раствор етс в воде.The resulting 2,4,6-tripyryl-5-triazine with m. Pl. 183 ° C are white needles. It dissolves well in acetone, dimethylformamide, poorly in ethanol and is not soluble in water.
Найдено, %: С 65,8, 65,47; В 4,29, 4,18; N 30,31, 30,24.Found,%: C 65.8, 65.47; B 4.29, 4.18; N 30.31, 30.24.
Вычислено, о/„: С 65„3; Н 4,3; N 30,4.Calculated, о / „: С 65„ 3; H 4.3; N 30.4.
CisHiaNo.CisHiaNo.
Предмет изО|бретени Subject of use
Claims (2)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU255285A1 true SU255285A1 (en) |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SU255285A1 (en) | ||
| KR100788529B1 (en) | 3-1-Hydroxy-Pentylidene-5-Nitro-3H-Benzofuran-2-One, a Process for the Preparation thereof and the Use thereof | |
| SU1470179A3 (en) | Method of producing tetramic acid | |
| SU405198A1 (en) | LIBRARY ^ | |
| SU558639A3 (en) | Method for preparing aminooxyhydroxamic acid derivatives or their salts | |
| SU327202A1 (en) | METHOD OF OBTAINING ARYLAMIDE | |
| US3296267A (en) | Preparation of 2, 3-dihydroxy-6-quinoxaline carboxylic acid | |
| SU287017A1 (en) | A METHOD FOR OBTAINING PHOSPHOLYLATED PENTHIAZINES | |
| SU327201A1 (en) | METHOD OF OBTAINING N-PILIMIDOB-2,3-CHINOXALYDICARBONIC ACID | |
| SU158576A1 (en) | ||
| SU327154A1 (en) | METHOD OF OBTAINING 2-CHINO-SALON-3-ILMETHYL-ALKYL-OR 2-CHINO-SALON-3-IL-METHYL-ALCOHOLES | |
| SU1728228A1 (en) | Method of 9,9-bis-(4-aminophenyl)-fluorene synthesis | |
| SU321118A1 (en) | METHOD OF OBTAINING 2-MERCAPTOTIAZOLO- | |
| SU258304A1 (en) | METHOD OF OBTAINING N-ACYLARENSULFAMIDES | |
| JP2716243B2 (en) | N-benzyl-3-hydroxysuccinamic acid and method for producing the same | |
| SU345162A1 (en) | METHOD OF OBTAINING 2- [7- (N-AJlKYLANILINO) p-OXIPROPYLMERCAPTO] -BENZYTHIAZOLES | |
| SU478833A1 (en) | The method of obtaining derivatives of thieno - (3,2-in) -pyrrole | |
| SU250904A1 (en) | METHOD OF OBTAINING FORMAMIDINSULFINAMIDINES | |
| SU247308A1 (en) | METHOD OF OBTAINING N-CARBAMOUS HILBENE DERIVATIVES OF BENZESOXAZOLONE | |
| SU255277A1 (en) | METHOD FOR PRODUCING DERIVATIVES OF BENZOKARBAZOLA The invention relates to the field of obtaining new compounds that can be used in the synthesis of biologically active substances. The proposed method of obtaining benzocarbazole derivatives of the formula R - P, Alk, Ar, R - Alk consists in the fact that 2-benzyl-5- methoxyindolyl-3-carboxylic acid or its ester of the formula R'OX ^^ ^ COOR "\ A ^ J-CH2-C6H5, where R is H, Alk, Ar; R" —H, Alk; R '—Alk; subjected to intramolecular cyclization in the presence of cyclizing agents, such as polyphosphoric acid, followed by isolation of the obtained product in a known manner. Example 1. 1,4-Dihydro-4-keto-6-methoxy | |
| SU517578A1 (en) | Method for producing substituted carboxylic acids | |
| SU355165A1 (en) | METHOD OF OBTAINING CATALYMAL ETHER | |
| SU253070A1 (en) | ||
| SU567402A3 (en) | Method of preparation of quinoline derivatives and salts thereof | |
| SU190897A1 (en) | METHOD OF OBTAINING ORGANIL |