SU1662573A1 - Preparation for disinfection of farm objects - Google Patents

Abstract

The invention relates to veterinary medicine. The purpose of the invention is to reduce toxicity for warm-blooded animals and increase the stability of the drug. The preparation contains a mixture of waste products from the production of methanol-formaldehyde isoprene, methylal-methanol fraction and a high-boiling by-product at a ratio of components by volume of 8: 1: 1. 5 tab.

Description

The invention relates to veterinary medicine.

The purpose of the invention is to reduce toxicity to warm-blooded animals and increase the stability of the drug.

This goal is achieved by using as a disinfectant waste and by-products of petrochemical production methylal methanol formaldehyde dioxane preparation, which is an intermediate product and a waste from the production of isoprene (a mixture of methanol-formaldehyde water, methylal methanol fraction and high boiling point by-product isoprene in a ratio of 8: 1 :one).

Methylal-methanol formaldehyde-dioxane preparation contains the following fractions: methanol formaldehyde water (IPM) - an intermediate product (80% is taken), which consists of the components: methanol (18-19%); formaldehyde (31-33%); water (48-49%); methylal-methanolic fraction (MMF) - waste (10% is taken), containing components: Ce (0.8-0.9%); trimethyl carbinol (38-42%); methanol (48-50%); formaldehyde (2-3%); water (5.9-6.3%); high boiling point byproduct (WFP) - waste (10% of the mixture is taken), containing components: dioxane alcohols I (7-10%); And (16-20%); III (4-6%); pyran alcohol (7-10%); ether trimethylcarbinol and dioxane alcohol II (6-8%); methylvinyldioxane (0.5-0.9%); isomethylvinyl dioxane (0.6-1.5%); methylbutanediol and trimethylcarbinol ether (3-5%); methyl butanediol alcohol (1-1.5%); pyranyl alcoholdioxin (2.5–4%); formaldehyde dioxane alcohol (15-20%), Methyl-methanol formaldehyde dioxane preparation is a slightly yellowish transparent liquid with a faint aromatic odor, well soluble in water in any ratios.

The composition is prepared as follows.

Take 8 parts of the IMF, then 1 part of the MMF and 1 part of the runway and mix. This solution is basic. From this solution, various percentage concentrations of the disinfectant are prepared (starting from 0.007 to 8%).

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PRI me R 1. Table 1 presents the antimicrobial action of methylal-methanol formaldehyde dioxane preparation,

PRI me R 2,

Table 2 presents the bactericidal activity of methylalmethanol formaldehyde dioxane preparation and its fractions.

Table 3 shows the bactericidal activity of methylalmethanol formaldehyde dioxane preparation in comparison with formalin with respect to the vegetative form of microbes and spores II of Zenkovsky vaccine protected by 20% inactivated horse serum (tissue test).

Table 4 shows the disinfecting activity of methylalanethanol formaldehyde dioxane preparation on test objects infected with pathogenic microorganisms ON million microbial cells per cm2 protected by sterile manure.

at the rate of 0.3 g per 100 cm2).

PRI me R 3. The disinfectant properties of the preparation were studied by standard methods on the board, brick, tiled, concrete surfaces of building test objects infected with suspensions of Escherichia coli strains, Staphylococcus aureus and 7-day spores of Tsenkovsky II vaccine with a density of 10 million microbial bodies per 1 cm2 and protected sterile manure at the rate of 0.3 g per 100 cm2. After applying the appropriate concentrations of the drug at the rate of 1 l per 1 m2 / after certain exposures with a sterile swab, samples were taken and after 3-fold washing in a sterile saline and centrifugation were sown on nutrient medium MPA; ENDO, BCH. After incubation in a thermostat for 168 h at 37 ° C, the results of the experiments were evaluated. Disinfecting activity - the drug is shown in Tables 3 and 4.

From the data of Tables 3 and 4 it can be seen that the drug has pronounced bacteriostatic, bactericidal and disinfecting properties.

In the study of acute oral toxic.

of the methylalanethanol formaldehyde dioxane preparation, it has been established that the absolutely fatal dose (LDUo)) for white mice is 1600 mg / kg,

Ldbo -1140mg / kg, the maximum tolerated (MTD) - 1200 mg / kg.

With the pathologic anatomical dissection of the dead animals, hyperemia of the fundus portion of the stomach, hemopoiescence of the liver, and punctate hemorrhages are not observed on the cortex of the kidneys.

In determining the acute oral toxicity of the fractions included in the proposed preparation, methanol-formaldehyde water shows almost the same toxicity with formalin, while other fractions are slightly toxic to warm-blooded animals (Table 5).

The resorptive toxicity of methylal-methanol formaldehyde dioxane preparation for white mice is characterized by the following parameters: LDU 12000 mg / kg; LDzo 6570 mg / kg; MTD 2700 mg / kg.

Claims (1)

When instillation in the rabbit's eyes of the drug in 5% concentration, no irritant effect was detected. Invention Formula A preparation for disinfecting livestock facilities containing methanol-, formaldehyde water, characterized in that, in order to reduce toxicity to warm-blooded animals and increase stability, the preparation additionally contains the waste products of the production of isoprene, the methyl-methanol fraction and the high boiling point byproduct with a ratio of components, respectively by volume: 8: 1: 1. Note. - - no growth of microorganisms; + - microbial growth. 100 0.31 100 5 100 50 100 0.062 100 0.062 0.031 0.25 0.031 0.062 0.062 0.5 with SP Yu 3 with Not investigated 50 0.062 0.062 Not investigated 1.0 1.0 oo 1Metipoal non-aaol formaldehyde Dnoxole preparation 2Formalin - ++ ++ ++ t1 - Not explored Oh o yu sl -j , about Note. - lack of growth of microorganisms; + - microbial growth. Note. The numerator shows exposure and concentration. , the drug on the vegetative forms of microbes, in the denominator of the spore; + - microbial growth; - - no growth 1Table Methyl-methanol formaldehyde dioxane prepa