EA000113B1 - Disinfectant compound "veltolene" - Google Patents

Abstract

The invention relates to disinfectants used in households and various public premises and in medicine. The compound contains the following components: didecyldimethyl ammonium bromide carbamide clathrate 18-22 wt.%; ethyl alcohol 18-22 wt.%; distilled water 56-64 wt.%.

Description

The invention relates to the field of sanitation and hygiene, in particular to means for disinfection of various rooms, household items, medical equipment and instruments, the surface of the body, the surgical field of patients, and is also used in other industries.

A known method of disinfection (ed. St. USSR No. 1475671, class F 61L 2/02, 1989), in which as a disinfectant use a composition consisting of a surface-active substance Biolot, chlorhexidine bigluconate, ethyl alcohol and water.

This composition has only antiseptic properties and its use involves the use of a special ultrasonic installation. A known Septabic disinfectant based on didecyldimethylammonium bromide clathrate with urea (Certificate No. 32 / 18-1 of the State Committee for Sanitary and Epidemiological Supervision of the Russian Federation of 04.15.94), which is a white, finely dispersed, odorless crystalline powder with the chemical formula | СН ₃ (СюН ₂₁ --------------- N ⁺ ------------ Ci “H ₂₁ ) Br '* (NH ₂ CONH ₂ ) ₁₆

CH ₃

Septabic is used as an aqueous solution and is quite effective against a number of infections. Its disadvantages include limited solubility (not more than 0.5 wt.%), A narrow spectrum of action, a fairly large flow rate and a limited selection of objects on which it can be used.

The aim of the present invention is to provide a disinfectant composition with greater efficiency, high efficiency, a wide spectrum of action and the possibility of easy disposal of used compounds.

The created disinfectant, hereinafter called Veltolen, possesses not only increased bactericidal, but also virucidal, fungicidal and insecticidal activity in comparison with analogues. Veltolen contains the following components, wt.%:

Urea didecyldimethylammonium bromide clathrate 20

Ethyl alcohol 20

Water 60

The composition of Veltolen is a clear solution with a weak specific odor. It mixes with water in any proportions and is stable during storage for two years at a temperature of no higher than 25 ° C. Working solutions remain active for seven days. The composition is undesirable to mix with soaps and anionic surfactants.

The working solution is prepared by diluting the Veltolen composition with an appropriate volume of water. Usually use 0.5; 1 and 2.5% Veltolen solutions. The disinfectant Veltolen is prepared as follows. 400 ml of water are placed in a container, 200 mg of 96% ethanol are added, then 200 g of urea didecyldimethylammonium bromide clathrate is loaded and 200 ml of water are added. After stirring, the mixture was allowed to settle and filtered.

Veltolen solutions have bactericidal activity against gram-negative and gram-positive bacteria, insecticidal, algicidal activity against dermatophytes and fungicidal activity against yeast-like fungi of the genus Candida, and also have virucidal action against certain lipophilic viruses (influenza virus, parainfluenza) herpes simplex, Japanese encephalitis. In addition, Veltolen solutions can significantly reduce the activity of type 1 human immunodeficiency virus, have a moderate virucidal effect on hepatitis A virus, and are active against tuberculosis, anthrax, plague and cholera.

Veltolen solutions are used to disinfect surfaces in rooms, equipment, hard furniture, surfaces of devices, apparatus, instruments, patient care items, linen, sanitary equipment, and cleaning material. In addition, they are used for pre-sterilization cleaning.

The table shows the results of comparative tests of the disinfectant Septabic (aqueous solution of clathrate) and the claimed drug "Veltolen". For testing, we used the concentrates of Septabic (20 wt.% Clathrate, the rest water) and “Veltolen” (20 wt.% Clathrate, 20 wt.% Ethanol, the rest water) diluted with water until the content of clathrate in the total mass of 0.5 wt.% .

Table

Test results for dermatophytosis and candidiasis

Disinfection object Activity on a ten-point scale (1 point 10%) * Septabic Veltolen. Indoor surfaces nine 10 Sanitary technical equipment nine 10 Lingerie 10 10 Patient Care Items 10 10

Medical Products not applicable nine

Test results for viral etiology infections

Indoor surfaces one nine Sanitary technical equipment 2 10 Lingerie 4 nine Patient Care Items one nine Medical Products not applicable nine

Tuberculosis Test Results

Indoor surfaces one 10 Sanitary technical equipment 0 nine Lingerie 0 nine Patient Care Items 0 nine Medical Products not applicable nine

Test results for especially dangerous infections (plague, cholera)

Indoor surfaces 0 nine Sanitary technical equipment 0 8 Lingerie 0 nine Patient Care Items 0 nine Medical Products not applicable 10

Test results for anthrax and anaerobic infections

Indoor surfaces 0 8 Sanitary technical equipment 0 8 Lingerie 0 nine Patient Care Items 0 nine Medical Products not applicable nine

* / Activity was evaluated on a ten-point scale corresponding to% disinfection per 1 m ² .

Veltolen solutions can be used in virology laboratories as a disinfectant for processing box rooms and laboratory equipment, work in which requires strict sterility rules. In addition, these solutions can be used in laboratories working with cell cultures, sterile solutions, environments for processing rooms, equipment, instruments and pretreatment of laboratory glassware in the form of a 0.1% solution. When working with epidemic encephalitis viruses, 0.1% Veltolen solution can be used for pretreatment of laboratory glassware, pipettes, dies, syringes, needles, rubber gloves for at least 1 hour. When working with material containing the herpes virus, 0 , 1% solution of Veltolen can be used for processing and pretreatment of laboratory and surgical instruments, gloves, and laboratory glassware. When working with material infected with HIV-1 viruses, a 0.5% solution of the drug can be used for pre-treatment for 1 hour with tools, gloves, gowns in combination with other reagents. Pretreatment of virus-containing materials suspected of being infected with hepatitis A virus with a 0.1% solution of the drug can be carried out for at least 1 hour. The Veltolen composition at a concentration of 0.5% can be recommended for pretreatment for 1-2 hours laboratory and clinical equipment contaminated with hepatitis B and C viruses, surgical instruments, rubber gloves, syringes, needles, tablet and other materials.

According to the toxic effect, Veltolen belongs to the 4th class of low-hazard substances with the inhalation exposure to vapors in saturated concentration and to the 3rd class of moderately hazardous substances when introduced into the stomach. The composition has a moderately irritating effect on the skin, mucous membranes and cornea. It has no inhalation effect on the respiratory system, does not have sensitizing properties.

In addition, Veltolen does not form environmentally hazardous compounds, does not destroy materials, and has both washing and deodorizing effects.

Claims (1)

CLAIM. A disinfectant composition containing an active substance - didecyldimethylammonium bromide clathrate with urea and water, characterized in that it additionally contains ethyl alcohol in the following ratio, wt.%: Didecyldimethyl Clathrate - urea ammonium bromide twenty Ethanol twenty Water 60 Eurasian Patent Organization, EAPO