SU1575937A3 - Способ получени 2-(7-хлор-1,8-нафтиридин-2-ил)-3-(4-метил-пентиламино)-1-изоиндолинона - Google Patents

Способ получени 2-(7-хлор-1,8-нафтиридин-2-ил)-3-(4-метил-пентиламино)-1-изоиндолинона Download PDF

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Publication number
SU1575937A3
SU1575937A3 SU884613053A SU4613053A SU1575937A3 SU 1575937 A3 SU1575937 A3 SU 1575937A3 SU 884613053 A SU884613053 A SU 884613053A SU 4613053 A SU4613053 A SU 4613053A SU 1575937 A3 SU1575937 A3 SU 1575937A3
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USSR - Soviet Union
Prior art keywords
pyrrolidinyl
alkyl
piperidyl
piperazinyl
unsubstituted
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SU884613053A
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English (en)
Inventor
Бурза Жан-Доминик
Капе Марк
Котрель Клод
Лабординьер Ришар
Пишен Филипп
Руссель Жерар
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Рон-Пуленк Санте (Фирма)
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Publication of SU1575937A3 publication Critical patent/SU1575937A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Изобретение относитс  к гетероциклическим соединени м, в частности к получению 2-(7-хлор-1,8-нафтиридин-2-ил)-3-(4-метил-пентиламино)-1-изоиндолинона, про вл ющего гипнотическое, антиконвульсивное и антиэтилептическое действи . Цель - разработка способа получени  соединени , обладающего указанными действи ми. Получение ведут реакцией 3-хлор-2-(7-хлор-1,8-нафтиридин-2-ил)-1-изоиндолинона с 4-метил-пентиламином в среде диметилформамида при 25-60°С.LD 50=90мг/кг, перорально у мыши. 1 табл.

Description

Атоксично
900 3,5 . 3,5
Атоксично
900 10,5 0,15
900 2,25
257 15

Claims (1)

  1. Формула изобретения Способ получения 2-(7-хлор-1,8-нафтиридин-2-ил)-3 - (4-метил-пентиламино)1-изоиндолинона формулы
    отличающийся тем, что,
    3-хлор-2-(7-хлор-1,8-нафтиридин-2-ил) 1-изоиндолинон формулы
    10
    N
    С1
    С1
    ИН-Ой2СН2СН2СНх
    СНз
    15
    подвергают взаимодействию с 4-метилпентиламином в среде диметилформамида при 25-60°С,
    Соединение Токсичность Ы>5-с, мг/кг орально (мышь) Сродство к рецепторным к бензодиазепину участкам (нМ) Тест на конвульсии к пднтетразолу (мьппь) , ЭД$.О, мг/кг орально Тест на прицепление (мышь) ЭД $0» мг/кг орально Соотношение прицепление пентетразол Предлагаемое Атоксично 900 3,5 3,5 900 257 Известное Атоксично 900 10,5 0,15 2,25 15
SU884613053A 1986-12-02 1988-12-15 Способ получени 2-(7-хлор-1,8-нафтиридин-2-ил)-3-(4-метил-пентиламино)-1-изоиндолинона SU1575937A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8616794A FR2607506B1 (fr) 1986-12-02 1986-12-02 Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
SU1575937A3 true SU1575937A3 (ru) 1990-06-30

Family

ID=9341441

Family Applications (5)

Application Number Title Priority Date Filing Date
SU874203789A SU1588280A3 (ru) 1986-12-02 1987-12-01 Способ получени производных пиррола или их фармацевтически приемлемых солей
SU884356998A SU1627083A3 (ru) 1986-12-02 1988-12-15 Способ получени производных изоиндолинона
SU884613053A SU1575937A3 (ru) 1986-12-02 1988-12-15 Способ получени 2-(7-хлор-1,8-нафтиридин-2-ил)-3-(4-метил-пентиламино)-1-изоиндолинона
SU884613006A SU1612997A3 (ru) 1986-12-02 1988-12-15 Способ получени производных пиррола или их фармацевтически приемлемых солей
SU884613037A SU1678202A3 (ru) 1986-12-02 1988-12-15 Способ получени производных пиррола

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SU874203789A SU1588280A3 (ru) 1986-12-02 1987-12-01 Способ получени производных пиррола или их фармацевтически приемлемых солей
SU884356998A SU1627083A3 (ru) 1986-12-02 1988-12-15 Способ получени производных изоиндолинона

Family Applications After (2)

Application Number Title Priority Date Filing Date
SU884613006A SU1612997A3 (ru) 1986-12-02 1988-12-15 Способ получени производных пиррола или их фармацевтически приемлемых солей
SU884613037A SU1678202A3 (ru) 1986-12-02 1988-12-15 Способ получени производных пиррола

Country Status (23)

Country Link
US (1) US4898871A (ru)
EP (1) EP0274929B1 (ru)
JP (1) JPS63154686A (ru)
KR (1) KR880007515A (ru)
AT (1) ATE66227T1 (ru)
AU (1) AU594538B2 (ru)
CA (1) CA1298294C (ru)
DE (1) DE3772187D1 (ru)
DK (1) DK630587A (ru)
ES (1) ES2038686T3 (ru)
FI (1) FI84721C (ru)
FR (1) FR2607506B1 (ru)
GR (1) GR3002472T3 (ru)
HU (1) HU199467B (ru)
IL (1) IL84656A (ru)
MA (1) MA21116A1 (ru)
MX (1) MX9557A (ru)
NO (1) NO166183C (ru)
NZ (1) NZ222750A (ru)
OA (1) OA08695A (ru)
PT (1) PT86259B (ru)
SU (5) SU1588280A3 (ru)
ZA (1) ZA878999B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607504B1 (fr) * 1986-12-02 1989-01-27 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2607503B1 (fr) * 1986-12-02 1989-02-24 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
AU2018392616B2 (en) 2017-12-21 2023-10-12 Ribon Therapeutics Inc. Quinazolinones as PARP14 inhibitors
CN112138003A (zh) * 2019-06-27 2020-12-29 中山大学 3-正丁基-异吲哚啉-1-酮在镇静、抗惊厥和抗癫痫的药物中的应用
WO2023192782A2 (en) * 2022-03-27 2023-10-05 Board Of Regents, The University Of Texas System Small molecule inhibitors of lanosterol synthase

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR203991A1 (es) * 1972-03-16 1975-11-12 Rhone Poulenc Sa Procedimiento para preparar derivados de(hidroxi-2-amino-3-propoxi)-3-isoindolinona-1
US4000306A (en) * 1973-02-08 1976-12-28 Rhone-Poulenc S.A. Anti-arrhythmic compositions containing isoindoline derivatives
FR2217000B1 (ru) * 1973-02-08 1976-04-09 Rhone Poulenc Ind
AR208414A1 (es) * 1974-11-07 1976-12-27 Rhone Poulenc Ind Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
CS274601B2 (en) * 1983-07-27 1991-09-15 Dainippon Pharmaceutical Co Method of 1,8-naphthyridine derivative production
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
NZ218773A (en) * 1986-01-06 1990-05-28 Carpibem 3-methyl-2-oxo-1-(substituted phenyl)-naphthyridines and pharmaceutical compositions
FR2607504B1 (fr) * 1986-12-02 1989-01-27 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2607503B1 (fr) * 1986-12-02 1989-02-24 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент СССР № 673173, кл. С 07 D 209/48, 1975. *

Also Published As

Publication number Publication date
FI84721C (fi) 1992-01-10
FI875297A0 (fi) 1987-12-01
SU1627083A3 (ru) 1991-02-07
HU199467B (en) 1990-02-28
MX9557A (es) 1993-10-01
ES2038686T3 (es) 1993-08-01
NO166183B (no) 1991-03-04
PT86259B (pt) 1990-11-07
EP0274929B1 (fr) 1991-08-14
FI875297A (fi) 1988-06-03
OA08695A (fr) 1989-03-31
NO875010D0 (no) 1987-12-01
DK630587D0 (da) 1987-12-01
FI84721B (fi) 1991-09-30
SU1588280A3 (ru) 1990-08-23
MA21116A1 (fr) 1988-07-01
AU594538B2 (en) 1990-03-08
US4898871A (en) 1990-02-06
AU8191787A (en) 1988-06-02
JPS63154686A (ja) 1988-06-27
CA1298294C (fr) 1992-03-31
PT86259A (fr) 1988-01-01
KR880007515A (ko) 1988-08-27
NO166183C (no) 1991-06-12
GR3002472T3 (en) 1992-12-30
FR2607506A1 (fr) 1988-06-03
HUT46008A (en) 1988-09-28
ZA878999B (en) 1988-07-27
DK630587A (da) 1988-06-03
SU1612997A3 (ru) 1990-12-07
IL84656A0 (en) 1988-04-29
NO875010L (no) 1988-06-03
ATE66227T1 (de) 1991-08-15
SU1678202A3 (ru) 1991-09-15
DE3772187D1 (de) 1991-09-19
NZ222750A (en) 1989-10-27
FR2607506B1 (fr) 1989-01-06
IL84656A (en) 1991-12-15
EP0274929A1 (fr) 1988-07-20

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