SU111218A1 - The method of obtaining the drug "Hexoni B-1.6 hexamethylene bis" (trimethylammonium benzenesulfonate) - Google Patents
The method of obtaining the drug "Hexoni B-1.6 hexamethylene bis" (trimethylammonium benzenesulfonate)Info
- Publication number
- SU111218A1 SU111218A1 SU580471A SU580471A SU111218A1 SU 111218 A1 SU111218 A1 SU 111218A1 SU 580471 A SU580471 A SU 580471A SU 580471 A SU580471 A SU 580471A SU 111218 A1 SU111218 A1 SU 111218A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- drug
- hexoni
- obtaining
- hexamethylene bis
- benzenesulfonate
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Предлагаетс способ получени препарата «Гексони ,6 гек€ а м е т и л с н - б и с (т р и м ет и л а м м о н л li бензолсульфоната), обладающего ганглиолитическим гипотензивным действием.A method is proposed for the preparation of the drug "Hexoni, 6 hexameters and ls n-b and c (t and m and l and m and m about n l li benzenesulfonate), which has a gangliolytic hypotensive effect.
Препарат получают путем обработки 1,6 гексаметилен-бис-диметиламина бензольным раствором метилового эфира бензол-сульфокислоты .The drug is obtained by treating 1.6 hexamethylene bis-dimethylamine with a benzene solution of methyl ester of benzene-sulfonic acid.
Способ осуществл етс следующим образом.The method is carried out as follows.
В круглодонную колбу, снабженную обратным холодильником, помещаетс молекул рное количество бензольного раствора 1,6-гексаметилен-бис-диметиламина и через холодильник, небольщими порци ми прибавл етс бис-молекул рное количество бензольного раствора метилового эфира бензол-сульфокислоты . Смесь быстро разогреваетс так, что вначале колбуприходитс охлаждать, а .после того, как бурное течение реакции проходит, процесс метилировани заканчиваетс кип чением на вод ной бане в течение двух часов.In a round bottom flask equipped with a reflux condenser, a molecular amount of a benzene solution of 1,6-hexamethylene-bis-dimethylamine is placed and a bis-molecular amount of a benzene solution of benzene-sulfonic acid methyl ester is added in small portions. The mixture is quickly heated so that at first the flashes are cooled, and after the vigorous reaction proceeds, the methylation process ends by boiling in a water bath for two hours.
Образующиес кристаллы отсасываютс и перекристаллизовываютс из гор чего абсолютного спирта . При охлаждении выпадают кристаллы с температурой плавлени 200-202°, выход-90%.The resulting crystals are sucked off and recrystallized from hot absolute alcohol. Upon cooling, crystals with a melting point of 200-202 ° precipitate, yield 90%.
Препарат предназначаетс при лечении спазма сосудов и гипертонии . Противопоказан при недостаточной функции почек , склерозе сосудов мозга, коронарных сосудов сердца и миокарде.The drug is intended for the treatment of vasospasm and hypertension. Contraindicated in case of insufficient kidney function, sclerosis of cerebral vessels, coronary vessels of the heart and myocardium.
Предмет изобретени Subject invention
1.Способ получени препарата «Гексони ,6 гексаметилен-бис (триметиламмоний бензолсульфоната ), отличающийс тем, что1. A method for preparing a Hexoni preparation, 6 hexamethylene bis (trimethylammonium benzenesulfonate), characterized in that
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU580471A SU111218A1 (en) | 1957-07-05 | 1957-07-05 | The method of obtaining the drug "Hexoni B-1.6 hexamethylene bis" (trimethylammonium benzenesulfonate) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU580471A SU111218A1 (en) | 1957-07-05 | 1957-07-05 | The method of obtaining the drug "Hexoni B-1.6 hexamethylene bis" (trimethylammonium benzenesulfonate) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU111218A1 true SU111218A1 (en) | 1957-11-30 |
Family
ID=48383871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU580471A SU111218A1 (en) | 1957-07-05 | 1957-07-05 | The method of obtaining the drug "Hexoni B-1.6 hexamethylene bis" (trimethylammonium benzenesulfonate) |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU111218A1 (en) |
-
1957
- 1957-07-05 SU SU580471A patent/SU111218A1/en active
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