SU1082338A3 - Способ выделени специфического фактора УШ - Google Patents
Способ выделени специфического фактора УШ Download PDFInfo
- Publication number
- SU1082338A3 SU1082338A3 SU782640948A SU2640948A SU1082338A3 SU 1082338 A3 SU1082338 A3 SU 1082338A3 SU 782640948 A SU782640948 A SU 782640948A SU 2640948 A SU2640948 A SU 2640948A SU 1082338 A3 SU1082338 A3 SU 1082338A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- anhydride
- water
- groups
- factor
- plasma
- Prior art date
Links
- 229960000301 factor viii Drugs 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims description 49
- 150000008064 anhydrides Chemical class 0.000 claims abstract description 45
- 229920000867 polyelectrolyte Polymers 0.000 claims abstract description 30
- 108010054218 Factor VIII Proteins 0.000 claims abstract description 16
- 102000001690 Factor VIII Human genes 0.000 claims abstract description 16
- 230000004913 activation Effects 0.000 claims abstract description 16
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 16
- 239000000178 monomer Substances 0.000 claims abstract description 9
- 229920000642 polymer Polymers 0.000 claims description 44
- 229920001577 copolymer Polymers 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 230000008569 process Effects 0.000 claims description 11
- 239000005977 Ethylene Substances 0.000 claims description 8
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 8
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 8
- 230000003993 interaction Effects 0.000 claims description 8
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 8
- 239000011976 maleic acid Substances 0.000 claims description 8
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 8
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- ASUDFOJKTJLAIK-UHFFFAOYSA-N 2-methoxyethanamine Chemical compound COCCN ASUDFOJKTJLAIK-UHFFFAOYSA-N 0.000 claims description 5
- 238000002955 isolation Methods 0.000 claims description 5
- 210000002966 serum Anatomy 0.000 claims description 5
- 238000010828 elution Methods 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- YYPNJNDODFVZLE-UHFFFAOYSA-N 3-methylbut-2-enoic acid Chemical compound CC(C)=CC(O)=O YYPNJNDODFVZLE-UHFFFAOYSA-N 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- 239000001569 carbon dioxide Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract description 13
- 239000003114 blood coagulation factor Substances 0.000 abstract description 8
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract description 7
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract description 7
- 229940019700 blood coagulation factors Drugs 0.000 abstract description 3
- 238000000926 separation method Methods 0.000 abstract description 2
- 102000004506 Blood Proteins Human genes 0.000 abstract 2
- 108010017384 Blood Proteins Proteins 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 55
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- 150000001412 amines Chemical class 0.000 description 39
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- 239000000203 mixture Substances 0.000 description 34
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 30
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 20
- -1 methoxypropyl Chemical group 0.000 description 19
- 239000002002 slurry Substances 0.000 description 19
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 18
- 239000008096 xylene Substances 0.000 description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 17
- 238000003756 stirring Methods 0.000 description 15
- 238000012360 testing method Methods 0.000 description 14
- FAXDZWQIWUSWJH-UHFFFAOYSA-N 3-methoxypropan-1-amine Chemical compound COCCCN FAXDZWQIWUSWJH-UHFFFAOYSA-N 0.000 description 12
- 238000010533 azeotropic distillation Methods 0.000 description 12
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- KFYRJJBUHYILSO-YFKPBYRVSA-N (2s)-2-amino-3-dimethylarsanylsulfanyl-3-methylbutanoic acid Chemical compound C[As](C)SC(C)(C)[C@@H](N)C(O)=O KFYRJJBUHYILSO-YFKPBYRVSA-N 0.000 description 8
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 8
- 102100022641 Coagulation factor IX Human genes 0.000 description 8
- 239000012267 brine Substances 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 8
- 230000035602 clotting Effects 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 8
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 7
- 206010053567 Coagulopathies Diseases 0.000 description 7
- 108010076282 Factor IX Proteins 0.000 description 7
- 230000000903 blocking effect Effects 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 229960004222 factor ix Drugs 0.000 description 7
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 7
- 150000003949 imides Chemical class 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 239000003431 cross linking reagent Substances 0.000 description 6
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 6
- 125000005462 imide group Chemical group 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 238000006467 substitution reaction Methods 0.000 description 6
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- 239000004698 Polyethylene Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 238000004132 cross linking Methods 0.000 description 5
- IUNMPGNGSSIWFP-UHFFFAOYSA-N dimethylaminopropylamine Chemical compound CN(C)CCCN IUNMPGNGSSIWFP-UHFFFAOYSA-N 0.000 description 5
- 229920000573 polyethylene Polymers 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 4
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- 238000002360 preparation method Methods 0.000 description 4
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- UIKUBYKUYUSRSM-UHFFFAOYSA-N 3-morpholinopropylamine Chemical compound NCCCN1CCOCC1 UIKUBYKUYUSRSM-UHFFFAOYSA-N 0.000 description 3
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- 229920000147 Styrene maleic anhydride Polymers 0.000 description 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
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- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
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- 239000002585 base Substances 0.000 description 1
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
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- UDGSVBYJWHOHNN-UHFFFAOYSA-N n',n'-diethylethane-1,2-diamine Chemical compound CCN(CC)CCN UDGSVBYJWHOHNN-UHFFFAOYSA-N 0.000 description 1
- QOHMWDJIBGVPIF-UHFFFAOYSA-N n',n'-diethylpropane-1,3-diamine Chemical compound CCN(CC)CCCN QOHMWDJIBGVPIF-UHFFFAOYSA-N 0.000 description 1
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- 239000004033 plastic Substances 0.000 description 1
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- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000379 polypropylene carbonate Polymers 0.000 description 1
- 230000020971 positive regulation of blood coagulation Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
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- HDOUGSFASVGDCS-UHFFFAOYSA-N pyridin-3-ylmethanamine Chemical compound NCC1=CC=CN=C1 HDOUGSFASVGDCS-UHFFFAOYSA-N 0.000 description 1
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- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L35/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/44—Preparation of metal salts or ammonium salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polyamides (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81891877A | 1977-07-25 | 1977-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1082338A3 true SU1082338A3 (ru) | 1984-03-23 |
Family
ID=25226749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU782640948A SU1082338A3 (ru) | 1977-07-25 | 1978-07-24 | Способ выделени специфического фактора УШ |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4157431A (enExample) |
| EP (1) | EP0000650B1 (enExample) |
| JP (1) | JPS5464623A (enExample) |
| AT (1) | AT363189B (enExample) |
| AU (1) | AU519848B2 (enExample) |
| BR (1) | BR7804728A (enExample) |
| CA (1) | CA1133191A (enExample) |
| DE (1) | DE2861003D1 (enExample) |
| ES (1) | ES471858A1 (enExample) |
| HU (1) | HU182537B (enExample) |
| IL (1) | IL55192A0 (enExample) |
| IT (1) | IT1097335B (enExample) |
| MX (1) | MX5386E (enExample) |
| PT (1) | PT68336B (enExample) |
| RO (1) | RO74902A (enExample) |
| SU (1) | SU1082338A3 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235881A (en) * | 1978-12-04 | 1980-11-25 | Cort Joseph H | Method for producing high potency factor VIII |
| US4293668A (en) * | 1979-12-26 | 1981-10-06 | Monsanto Company | Refining olefin/maleic acid copolymers by extraction with alkanes |
| US4287180A (en) * | 1980-01-28 | 1981-09-01 | Baxter Travenol Laboratories, Inc. | Method for treating blood clotting factor inhibitors |
| US4421653A (en) * | 1980-02-08 | 1983-12-20 | Hoffmann-La Roche Inc. | Process for the deproteinization of biological fluids |
| US4471112A (en) * | 1982-06-28 | 1984-09-11 | Monsanto Company | Heparin polyelectrolyte polymer complex |
| US4397841A (en) * | 1982-06-28 | 1983-08-09 | Monsanto Company | Production of blood coagulation factor VIII:C |
| US4382028A (en) * | 1982-07-19 | 1983-05-03 | Monsanto Company | Separation of plasma proteins from cell culture systems |
| US4632962A (en) * | 1984-12-24 | 1986-12-30 | General Electric Company | Hydroxyl group graft modified polyolefins |
| US4654401A (en) * | 1984-12-24 | 1987-03-31 | General Electric Company | Hydroxyl group graft modified polyolefins |
| US4668412A (en) * | 1985-06-27 | 1987-05-26 | Texaco Inc. | Lubricating oil containing dispersant VII and pour depressant |
| US4954574A (en) * | 1985-08-27 | 1990-09-04 | Rohm And Haas Company | Imide polymers |
| US5004777A (en) * | 1985-08-27 | 1991-04-02 | Rohm And Haas Company | Imide polymers |
| US4727117A (en) * | 1985-08-27 | 1988-02-23 | Rohm And Haas Company | Imide polymers |
| US5264483A (en) * | 1985-08-27 | 1993-11-23 | Rohm And Haas Company | Imide polymers |
| IT1224419B (it) * | 1987-12-29 | 1990-10-04 | Montedipe Spa | Processo per imidizzare copolimeri dell'anidride maleica con monomeri vinil aromatici |
| GB8913183D0 (en) * | 1989-06-08 | 1989-07-26 | Central Blood Lab Authority | Chemical products |
| FR2651437A1 (fr) * | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
| WO1993009869A1 (fr) * | 1991-11-12 | 1993-05-27 | Asahi Kasei Kogyo Kabushiki Kaisha | Adsorbant pour le facteur viii de la coagulation sanguine |
| CN101748117B (zh) * | 2005-02-10 | 2014-03-26 | 恰根有限公司 | 反应表面的样品裂解和涂层 |
| CN111454408B (zh) * | 2020-04-29 | 2022-09-20 | 湖北科技学院 | 纳米氧化物基血液快速促凝剂的预辐射接枝合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB922878A (en) * | 1958-06-26 | 1963-04-03 | Monsanto Chemicals | Oil-soluble copolymeric materials and compositions containing the same |
| US3157595A (en) * | 1959-09-16 | 1964-11-17 | Monsanto Co | Clarification of water with copolymers containing half-amides of olefinic anhydrides |
| US3554985A (en) * | 1963-01-02 | 1971-01-12 | Monsanto Co | Cross-linked copolymer polyelectrolytes based on alpha,beta-ethylenically unsaturated acids |
| US3340680A (en) * | 1966-02-01 | 1967-09-12 | Monsanto Co | Air purification process |
| US3651213A (en) * | 1969-05-29 | 1972-03-21 | Monsanto Co | Method for the immunization of a living animal body against viral disease |
| US3555001A (en) * | 1969-05-29 | 1971-01-12 | Monsanto Co | Process for the fractionation of plasma and serum using water-insoluble polyelectrolytes containing diloweralkylaminoloweralkylimide groups |
| US3655509A (en) * | 1969-05-29 | 1972-04-11 | Monsanto Co | Process for the separation of virus from non-viral proteins |
| US3682881A (en) * | 1970-10-02 | 1972-08-08 | Baxter Laboratories Inc | Fractionation of plasma using glycine and polyethylene glycol |
| US4081432A (en) * | 1977-07-25 | 1978-03-28 | Monsanto Company | Method of separating a Factor IX preparation from plasma using ethylene-maleic anhydride polymers |
-
1978
- 1978-07-19 ES ES471858A patent/ES471858A1/es not_active Expired
- 1978-07-21 AU AU38242/78A patent/AU519848B2/en not_active Expired
- 1978-07-21 AT AT0531678A patent/AT363189B/de not_active IP Right Cessation
- 1978-07-21 HU HU78MO1021A patent/HU182537B/hu not_active IP Right Cessation
- 1978-07-21 BR BR7804728A patent/BR7804728A/pt unknown
- 1978-07-21 DE DE7878300176T patent/DE2861003D1/de not_active Expired
- 1978-07-21 MX MX787272U patent/MX5386E/es unknown
- 1978-07-21 EP EP78300176A patent/EP0000650B1/en not_active Expired
- 1978-07-21 RO RO7894743A patent/RO74902A/ro unknown
- 1978-07-21 IL IL55192A patent/IL55192A0/xx not_active IP Right Cessation
- 1978-07-21 IT IT26003/78A patent/IT1097335B/it active
- 1978-07-21 PT PT68336A patent/PT68336B/pt unknown
- 1978-07-21 JP JP8930878A patent/JPS5464623A/ja active Granted
- 1978-07-24 SU SU782640948A patent/SU1082338A3/ru active
- 1978-07-24 CA CA308,000A patent/CA1133191A/en not_active Expired
- 1978-08-15 US US05/933,698 patent/US4157431A/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 1. Патент US 3682881, кл. 260-112, опублик. 1972. 2. Патент US № 3555001, кл. 260-112, опублик. 1971. * |
Also Published As
| Publication number | Publication date |
|---|---|
| ATA531678A (de) | 1980-12-15 |
| JPS6241212B2 (enExample) | 1987-09-02 |
| DE2861003D1 (en) | 1981-11-26 |
| US4157431A (en) | 1979-06-05 |
| IT1097335B (it) | 1985-08-31 |
| MX5386E (es) | 1983-07-04 |
| IL55192A0 (en) | 1978-09-29 |
| RO74902A (ro) | 1982-04-12 |
| EP0000650A3 (en) | 1979-04-04 |
| PT68336B (pt) | 1994-02-25 |
| PT68336A (en) | 1978-08-01 |
| JPS5464623A (en) | 1979-05-24 |
| AU3824278A (en) | 1980-01-24 |
| AT363189B (de) | 1981-07-10 |
| BR7804728A (pt) | 1979-04-03 |
| IT7826003A0 (it) | 1978-07-21 |
| CA1133191A (en) | 1982-10-05 |
| EP0000650A2 (en) | 1979-02-07 |
| AU519848B2 (en) | 1981-12-24 |
| EP0000650B1 (en) | 1981-09-02 |
| ES471858A1 (es) | 1979-02-01 |
| HU182537B (en) | 1984-02-28 |
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