SMT201500028B - N-(4-((3-(2-ammino-4-pirimidinil)-2-piridinil)ossi)fenil)-4-(4-metil-2-tienil)-trattamento di un cancro resistente ad agenti antimitotici - Google Patents

N-(4-((3-(2-ammino-4-pirimidinil)-2-piridinil)ossi)fenil)-4-(4-metil-2-tienil)-trattamento di un cancro resistente ad agenti antimitotici

Info

Publication number
SMT201500028B
SMT201500028B SM201500028T SM201500028T SMT201500028B SM T201500028 B SMT201500028 B SM T201500028B SM 201500028 T SM201500028 T SM 201500028T SM 201500028 T SM201500028 T SM 201500028T SM T201500028 B SMT201500028 B SM T201500028B
Authority
SM
San Marino
Prior art keywords
pyridinyl
pyrimidinyl
thienyl
oxy
phenyl
Prior art date
Application number
SM201500028T
Other languages
English (en)
Italian (it)
Inventor
Marc Payton
Richard Kendall
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43216900&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201500028(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SMT201500028B publication Critical patent/SMT201500028B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
SM201500028T 2009-09-11 2015-02-09 N-(4-((3-(2-ammino-4-pirimidinil)-2-piridinil)ossi)fenil)-4-(4-metil-2-tienil)-trattamento di un cancro resistente ad agenti antimitotici SMT201500028B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24152709P 2009-09-11 2009-09-11
PCT/US2010/048247 WO2011031842A1 (en) 2009-09-11 2010-09-09 N-4 ( - ( ( 3- ( 2 -amino-4 pyrimidinyl) -2 -pyridinyl) oxy) phenyl) -4- (4-methyl-2-thienyl) -1-phthalazinamine for use in the treatment of antimitotic agent resistant cancer

Publications (1)

Publication Number Publication Date
SMT201500028B true SMT201500028B (it) 2015-03-05

Family

ID=43216900

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201500028T SMT201500028B (it) 2009-09-11 2015-02-09 N-(4-((3-(2-ammino-4-pirimidinil)-2-piridinil)ossi)fenil)-4-(4-metil-2-tienil)-trattamento di un cancro resistente ad agenti antimitotici

Country Status (33)

Country Link
US (1) US20120028917A1 (xx)
EP (2) EP2818170B1 (xx)
JP (1) JP5851403B2 (xx)
KR (1) KR20120082896A (xx)
CN (1) CN102869361A (xx)
AU (1) AU2010292225C1 (xx)
BR (1) BR112012008325A2 (xx)
CA (1) CA2773838C (xx)
CL (1) CL2012000640A1 (xx)
CR (1) CR20120171A (xx)
DK (1) DK2475368T3 (xx)
EA (1) EA020526B1 (xx)
ES (1) ES2528485T3 (xx)
HK (2) HK1173655A1 (xx)
HR (1) HRP20150104T1 (xx)
HU (1) HUE024568T2 (xx)
IL (1) IL218569A0 (xx)
MA (1) MA33658B1 (xx)
ME (1) ME02048B (xx)
MX (1) MX2012003041A (xx)
NZ (1) NZ598758A (xx)
PE (1) PE20120895A1 (xx)
PL (1) PL2475368T3 (xx)
PT (1) PT2475368E (xx)
RS (1) RS53807B1 (xx)
SG (1) SG179102A1 (xx)
SI (1) SI2475368T1 (xx)
SM (1) SMT201500028B (xx)
TN (1) TN2012000110A1 (xx)
TW (1) TW201121956A (xx)
UA (1) UA107675C2 (xx)
WO (1) WO2011031842A1 (xx)
ZA (1) ZA201202472B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921367B2 (en) 2012-05-31 2014-12-30 Amgen Inc. Use of AMG 900 for the treatment of cancer
CN103664737A (zh) * 2012-09-25 2014-03-26 杨子娇 一类治疗房角狭窄的化合物及其用途
US9963701B2 (en) 2013-09-30 2018-05-08 Korea Institute Of Radiological & Medical Sciences Pharmaceutical composition for treatment of radiation- or drug-resistant cancer comprising HRP-3 inhibitor
DK3068393T5 (da) 2013-11-11 2022-08-22 Amgen Inc Kombinationsterapi som inkluderer en mdm2-inhibitor og et eller flere yderligere farmaceutisk aktive midler til behandlingen af kræftformer
AU2014357545B2 (en) * 2013-12-03 2018-10-25 Amgen Inc. Crystalline forms of N-(4-((3-(2-amino-4-pyrimidinyl) - 2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1 -phthalazinamine pharmaceutically acceptable salts and uses thereof
CN114634483A (zh) * 2014-02-21 2022-06-17 弗洛斯特生物科技有限公司 用于治疗癌症和增殖性疾病的抗有丝分裂酰胺
AU2017248807A1 (en) * 2016-04-15 2018-10-25 Felicitex Therapeutics, Inc. Combinations for the treatment of neoplasms using quiescent cell targeting and inhibitors of mitosis
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
AU2019262589B2 (en) 2018-05-04 2022-07-07 Amgen Inc. KRAS G12C inhibitors and methods of using the same
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
SG11202112855WA (en) 2019-05-21 2021-12-30 Amgen Inc Solid state forms

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005002571A1 (en) * 2003-07-03 2005-01-13 Cambridge University Technical Services Ltd Use of aurora kinase inhibitors for reducing the resistance of cancer cells
US7560551B2 (en) * 2006-01-23 2009-07-14 Amgen Inc. Aurora kinase modulators and method of use
JP5280862B2 (ja) 2006-01-23 2013-09-04 アムジエン・インコーポレーテツド オーロラキナーゼ調節剤および使用方法
CN101405282B (zh) * 2006-01-23 2015-03-25 安姆根有限公司 极光激酶调节剂和使用方法
GB0609619D0 (en) * 2006-05-16 2006-06-21 Astrazeneca Ab Combination
GB0609621D0 (en) * 2006-05-16 2006-06-21 Astrazeneca Ab Novel co-crystal

Also Published As

Publication number Publication date
SI2475368T1 (sl) 2015-03-31
EP2818170A1 (en) 2014-12-31
JP2013504582A (ja) 2013-02-07
NZ598758A (en) 2013-12-20
UA107675C2 (xx) 2015-02-10
CL2012000640A1 (es) 2012-09-21
CA2773838C (en) 2016-05-31
ES2528485T3 (es) 2015-02-10
EP2475368B1 (en) 2014-12-17
HK1205457A1 (en) 2015-12-18
HUE024568T2 (hu) 2016-02-29
US20120028917A1 (en) 2012-02-02
BR112012008325A2 (pt) 2017-08-29
ZA201202472B (en) 2012-12-27
MX2012003041A (es) 2012-06-27
HK1173655A1 (en) 2013-05-24
CN102869361A (zh) 2013-01-09
EP2475368A1 (en) 2012-07-18
JP5851403B2 (ja) 2016-02-03
TW201121956A (en) 2011-07-01
PE20120895A1 (es) 2012-08-19
PL2475368T3 (pl) 2015-05-29
TN2012000110A1 (en) 2013-09-19
AU2010292225B2 (en) 2012-12-13
SG179102A1 (en) 2012-04-27
EA201270383A1 (ru) 2013-04-30
EP2818170B1 (en) 2018-12-05
ME02048B (me) 2015-05-20
AU2010292225A1 (en) 2012-04-12
IL218569A0 (en) 2012-05-31
HRP20150104T1 (xx) 2015-03-13
DK2475368T3 (en) 2015-03-09
KR20120082896A (ko) 2012-07-24
PT2475368E (pt) 2015-02-10
RS53807B1 (en) 2015-06-30
CA2773838A1 (en) 2011-03-17
AU2010292225C1 (en) 2013-06-27
EA020526B1 (ru) 2014-11-28
CR20120171A (es) 2012-08-09
WO2011031842A1 (en) 2011-03-17
MA33658B1 (fr) 2012-10-01

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