SMT201500003B - Nuovo derivato di fenilimidazolo come inibitore dell'enzima PDE10A - Google Patents
Nuovo derivato di fenilimidazolo come inibitore dell'enzima PDE10AInfo
- Publication number
- SMT201500003B SMT201500003B SM201500003T SM201500003T SMT201500003B SM T201500003 B SMT201500003 B SM T201500003B SM 201500003 T SM201500003 T SM 201500003T SM 201500003 T SM201500003 T SM 201500003T SM T201500003 B SMT201500003 B SM T201500003B
- Authority
- SM
- San Marino
- Prior art keywords
- new
- enzyme inhibitor
- pde10a enzyme
- phenylimidazole derivative
- phenylimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/DK2009/050134 WO2009152825A1 (en) | 2008-06-20 | 2009-06-19 | Novel phenylimidazole derivatives as pde10a enzyme inhibitors |
| PCT/DK2010/050147 WO2010145668A1 (en) | 2009-06-19 | 2010-06-17 | Novel phenylimidazole derivative as pde10a enzyme inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201500003B true SMT201500003B (it) | 2015-03-05 |
Family
ID=42321053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201500003T SMT201500003B (it) | 2009-06-19 | 2015-01-05 | Nuovo derivato di fenilimidazolo come inibitore dell'enzima PDE10A |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP2443105B1 (enExample) |
| JP (1) | JP5768044B2 (enExample) |
| AR (1) | AR077144A1 (enExample) |
| AU (1) | AU2010262190B2 (enExample) |
| BR (1) | BRPI1015983A2 (enExample) |
| CA (1) | CA2765750A1 (enExample) |
| CR (1) | CR20110654A (enExample) |
| CY (1) | CY1115971T1 (enExample) |
| DK (1) | DK2443105T3 (enExample) |
| DO (1) | DOP2011000397A (enExample) |
| ES (1) | ES2527216T3 (enExample) |
| GE (1) | GEP20146100B (enExample) |
| GT (1) | GT201100322A (enExample) |
| HR (1) | HRP20141222T1 (enExample) |
| IL (1) | IL216684A (enExample) |
| MA (1) | MA33367B1 (enExample) |
| MX (1) | MX2011013400A (enExample) |
| MY (1) | MY156785A (enExample) |
| NZ (1) | NZ597203A (enExample) |
| PL (1) | PL2443105T3 (enExample) |
| PT (1) | PT2443105E (enExample) |
| SG (1) | SG176680A1 (enExample) |
| SI (1) | SI2443105T1 (enExample) |
| SM (1) | SMT201500003B (enExample) |
| TW (1) | TW201100430A (enExample) |
| UA (1) | UA106378C2 (enExample) |
| WO (1) | WO2010145668A1 (enExample) |
| ZA (1) | ZA201109271B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
| TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
| US8552045B2 (en) | 2010-11-19 | 2013-10-08 | H. Lundbeck A/S | Tricyclic imidazole compounds as PDE10 inhibitors |
| JO3089B1 (ar) * | 2010-11-19 | 2017-03-15 | H Lundbeck As | مشتقات ايميدازول كمثبطات لانزيمات pde10a |
| WO2012112946A1 (en) | 2011-02-18 | 2012-08-23 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| WO2013034758A1 (en) * | 2011-09-09 | 2013-03-14 | H. Lundbeck A/S | Substituted triazolopyrazines and uses thereof |
| US9056863B2 (en) | 2011-09-09 | 2015-06-16 | H. Lundbeck A/S | Substituted 2,3,5,9,9B-pentaazacyclopenta[a]naphthalenes and uses thereof |
| CN103874701A (zh) * | 2011-09-09 | 2014-06-18 | H.隆德贝克有限公司 | 吡啶化合物和其用途 |
| WO2013034755A1 (en) * | 2011-09-09 | 2013-03-14 | H. Lundbeck A/S | Triazolopyrazine derivatives and their use for treating neurological and psychiatric disorders |
| TWI570124B (zh) | 2011-12-21 | 2017-02-11 | Ｈ 朗德貝克公司 | 作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物 |
| WO2013107856A1 (en) * | 2012-01-20 | 2013-07-25 | H. Lundbeck A/S | Imidazole derivatives as pde10a enzyme inhibitors |
| WO2013127817A1 (en) | 2012-02-27 | 2013-09-06 | H. Lundbeck A/S | Imidazole derivatives as pde10a enzyme inhibitors |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| BR112020013743A2 (pt) * | 2018-11-06 | 2020-12-01 | H. Lundbeck A/S | hemiadipato de 5,8-dimetil-2-[2-(1-metil-4-fenil-1h-imidazol-2-il)-etil]-[1,2,4]triazolo[1,5-a]pirazina |
| WO2020094592A1 (en) * | 2018-11-06 | 2020-05-14 | H. Lundbeck A/S | Compounds for treating negative symptoms and cognitive impairments |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826833A (en) | 1984-01-30 | 1989-05-02 | Pfizer Inc. | 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof |
| US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| IL149106A0 (en) | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
| FR2824065A1 (fr) | 2001-04-26 | 2002-10-31 | Neuro3D | Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations |
| WO2004024705A1 (ja) | 2002-09-10 | 2004-03-25 | Takeda Pharmaceutical Company Limited | ５員複素環化合物 |
| AU2003288352A1 (en) | 2002-10-30 | 2004-06-07 | Centre National De La Recherche Scientifique (Cnrs) | Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses |
| EP1641457B1 (en) | 2003-06-30 | 2009-08-05 | Nycomed GmbH | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors |
| MXPA05013553A (es) | 2003-06-30 | 2006-03-09 | Altana Pharma Ag | Pirrolodihidroisoquinolinas como inhibidores de pde10. |
| EP1651251A4 (en) | 2003-07-31 | 2008-06-18 | Bayer Pharmaceuticals Corp | METHOD FOR THE TREATMENT OF DIABETES AND RELATED DISEASES USING PDE 10A INHIBITORS |
| EP1723134A2 (en) | 2004-02-18 | 2006-11-22 | Pfizer Products Incorporated | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline |
| FR2870539B1 (fr) | 2004-05-19 | 2006-08-04 | Greenpharma Sa Sa | Nouvelles methodes et medicaments |
| BRPI0511854A (pt) | 2004-06-07 | 2008-01-15 | Pfizer Prod Inc | inibição de fosfodiestearase 10 como tratamento para condições relacionados com a obesidade e relacionadas a sìndrome metabólica |
| US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
| CA2578996A1 (en) | 2004-09-03 | 2006-03-16 | Memory Pharmaceuticals Corporation | 4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms |
| US20060183763A1 (en) * | 2004-12-31 | 2006-08-17 | Pfizer Inc | Novel pyrrolidyl derivatives of heteroaromatic compounds |
| MX2008010668A (es) * | 2006-02-21 | 2008-10-01 | Amgen Inc | Derivados de cinolina como inhibidores de fosfodiesterasa 10. |
| TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
-
2010
- 2010-06-17 PT PT107253734T patent/PT2443105E/pt unknown
- 2010-06-17 GE GEAP201012536A patent/GEP20146100B/en unknown
- 2010-06-17 NZ NZ597203A patent/NZ597203A/xx not_active IP Right Cessation
- 2010-06-17 SI SI201030841T patent/SI2443105T1/sl unknown
- 2010-06-17 HR HRP20141222AT patent/HRP20141222T1/hr unknown
- 2010-06-17 BR BRPI1015983A patent/BRPI1015983A2/pt not_active Application Discontinuation
- 2010-06-17 PL PL10725373T patent/PL2443105T3/pl unknown
- 2010-06-17 DK DK10725373.4T patent/DK2443105T3/en active
- 2010-06-17 JP JP2012515356A patent/JP5768044B2/ja not_active Expired - Fee Related
- 2010-06-17 MY MYPI2011005865A patent/MY156785A/en unknown
- 2010-06-17 UA UAA201200499A patent/UA106378C2/ru unknown
- 2010-06-17 SG SG2011089919A patent/SG176680A1/en unknown
- 2010-06-17 MA MA34464A patent/MA33367B1/fr unknown
- 2010-06-17 AU AU2010262190A patent/AU2010262190B2/en not_active Ceased
- 2010-06-17 WO PCT/DK2010/050147 patent/WO2010145668A1/en not_active Ceased
- 2010-06-17 MX MX2011013400A patent/MX2011013400A/es unknown
- 2010-06-17 EP EP10725373.4A patent/EP2443105B1/en active Active
- 2010-06-17 CA CA2765750A patent/CA2765750A1/en not_active Abandoned
- 2010-06-17 ES ES10725373.4T patent/ES2527216T3/es active Active
- 2010-06-18 TW TW099119840A patent/TW201100430A/zh unknown
- 2010-06-18 AR ARP100102165A patent/AR077144A1/es active IP Right Grant
-
2011
- 2011-11-29 IL IL216684A patent/IL216684A/en active IP Right Grant
- 2011-12-08 CR CR20110654A patent/CR20110654A/es unknown
- 2011-12-14 GT GT201100322A patent/GT201100322A/es unknown
- 2011-12-15 ZA ZA2011/09271A patent/ZA201109271B/en unknown
- 2011-12-19 DO DO2011000397A patent/DOP2011000397A/es unknown
-
2014
- 2014-12-19 CY CY20141101071T patent/CY1115971T1/el unknown
-
2015
- 2015-01-05 SM SM201500003T patent/SMT201500003B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2765750A1 (en) | 2010-12-23 |
| ES2527216T3 (es) | 2015-01-21 |
| HRP20141222T1 (hr) | 2015-02-27 |
| WO2010145668A1 (en) | 2010-12-23 |
| AU2010262190A1 (en) | 2012-01-19 |
| SG176680A1 (en) | 2012-01-30 |
| AR077144A1 (es) | 2011-08-03 |
| MY156785A (en) | 2016-03-31 |
| CY1115971T1 (el) | 2017-01-25 |
| ZA201109271B (en) | 2013-02-27 |
| GT201100322A (es) | 2014-02-06 |
| IL216684A (en) | 2016-03-31 |
| MA33367B1 (fr) | 2012-06-01 |
| JP5768044B2 (ja) | 2015-08-26 |
| JP2012530086A (ja) | 2012-11-29 |
| SI2443105T1 (sl) | 2015-02-27 |
| GEP20146100B (en) | 2014-05-27 |
| UA106378C2 (ru) | 2014-08-26 |
| PL2443105T3 (pl) | 2015-03-31 |
| CR20110654A (es) | 2012-03-09 |
| EP2443105A1 (en) | 2012-04-25 |
| IL216684A0 (en) | 2012-02-29 |
| PT2443105E (pt) | 2015-01-14 |
| DOP2011000397A (es) | 2012-07-15 |
| TW201100430A (en) | 2011-01-01 |
| BRPI1015983A2 (pt) | 2016-04-19 |
| MX2011013400A (es) | 2012-02-21 |
| DK2443105T3 (en) | 2015-01-12 |
| EP2443105B1 (en) | 2014-10-29 |
| AU2010262190B2 (en) | 2013-01-31 |
| HK1171446A1 (en) | 2013-03-28 |
| NZ597203A (en) | 2013-03-28 |
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