IL216684A - 5,8-dimethyl-2-[2-(1-methyl-4-phenyl-1 h-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine, use thereof and pharmaceutical composition comprising same - Google Patents

5,8-dimethyl-2-[2-(1-methyl-4-phenyl-1 h-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine, use thereof and pharmaceutical composition comprising same

Info

Publication number
IL216684A
IL216684A IL216684A IL21668411A IL216684A IL 216684 A IL216684 A IL 216684A IL 216684 A IL216684 A IL 216684A IL 21668411 A IL21668411 A IL 21668411A IL 216684 A IL216684 A IL 216684A
Authority
IL
Israel
Prior art keywords
triazolo
pyrazine
imidazole
dimethyl
phenyl
Prior art date
Application number
IL216684A
Other languages
English (en)
Hebrew (he)
Other versions
IL216684A0 (en
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2009/050134 external-priority patent/WO2009152825A1/en
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of IL216684A0 publication Critical patent/IL216684A0/en
Publication of IL216684A publication Critical patent/IL216684A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL216684A 2009-06-19 2011-11-29 5,8-dimethyl-2-[2-(1-methyl-4-phenyl-1 h-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine, use thereof and pharmaceutical composition comprising same IL216684A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DK2009/050134 WO2009152825A1 (en) 2008-06-20 2009-06-19 Novel phenylimidazole derivatives as pde10a enzyme inhibitors
PCT/DK2010/050147 WO2010145668A1 (en) 2009-06-19 2010-06-17 Novel phenylimidazole derivative as pde10a enzyme inhibitor

Publications (2)

Publication Number Publication Date
IL216684A0 IL216684A0 (en) 2012-02-29
IL216684A true IL216684A (en) 2016-03-31

Family

ID=42321053

Family Applications (1)

Application Number Title Priority Date Filing Date
IL216684A IL216684A (en) 2009-06-19 2011-11-29 5,8-dimethyl-2-[2-(1-methyl-4-phenyl-1 h-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine, use thereof and pharmaceutical composition comprising same

Country Status (28)

Country Link
EP (1) EP2443105B1 (enExample)
JP (1) JP5768044B2 (enExample)
AR (1) AR077144A1 (enExample)
AU (1) AU2010262190B2 (enExample)
BR (1) BRPI1015983A2 (enExample)
CA (1) CA2765750A1 (enExample)
CR (1) CR20110654A (enExample)
CY (1) CY1115971T1 (enExample)
DK (1) DK2443105T3 (enExample)
DO (1) DOP2011000397A (enExample)
ES (1) ES2527216T3 (enExample)
GE (1) GEP20146100B (enExample)
GT (1) GT201100322A (enExample)
HR (1) HRP20141222T1 (enExample)
IL (1) IL216684A (enExample)
MA (1) MA33367B1 (enExample)
MX (1) MX2011013400A (enExample)
MY (1) MY156785A (enExample)
NZ (1) NZ597203A (enExample)
PL (1) PL2443105T3 (enExample)
PT (1) PT2443105E (enExample)
SG (1) SG176680A1 (enExample)
SI (1) SI2443105T1 (enExample)
SM (1) SMT201500003B (enExample)
TW (1) TW201100430A (enExample)
UA (1) UA106378C2 (enExample)
WO (1) WO2010145668A1 (enExample)
ZA (1) ZA201109271B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI501965B (zh) 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
US8133897B2 (en) 2008-06-20 2012-03-13 H. Lundbeck A/S Phenylimidazole derivatives as PDE10A enzyme inhibitors
TWI485151B (zh) 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
US8552045B2 (en) 2010-11-19 2013-10-08 H. Lundbeck A/S Tricyclic imidazole compounds as PDE10 inhibitors
JO3089B1 (ar) * 2010-11-19 2017-03-15 H Lundbeck As مشتقات ايميدازول كمثبطات لانزيمات pde10a
WO2012112946A1 (en) 2011-02-18 2012-08-23 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a)
WO2013034758A1 (en) * 2011-09-09 2013-03-14 H. Lundbeck A/S Substituted triazolopyrazines and uses thereof
US9056863B2 (en) 2011-09-09 2015-06-16 H. Lundbeck A/S Substituted 2,3,5,9,9B-pentaazacyclopenta[a]naphthalenes and uses thereof
CN103874701A (zh) * 2011-09-09 2014-06-18 H.隆德贝克有限公司 吡啶化合物和其用途
WO2013034755A1 (en) * 2011-09-09 2013-03-14 H. Lundbeck A/S Triazolopyrazine derivatives and their use for treating neurological and psychiatric disorders
TWI570124B (zh) 2011-12-21 2017-02-11 Ｈ 朗德貝克公司 作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物
WO2013107856A1 (en) * 2012-01-20 2013-07-25 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
WO2013127817A1 (en) 2012-02-27 2013-09-06 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
BR112020013743A2 (pt) * 2018-11-06 2020-12-01 H. Lundbeck A/S hemiadipato de 5,8-dimetil-2-[2-(1-metil-4-fenil-1h-imidazol-2-il)-etil]-[1,2,4]triazolo[1,5-a]pirazina
WO2020094592A1 (en) * 2018-11-06 2020-05-14 H. Lundbeck A/S Compounds for treating negative symptoms and cognitive impairments

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826833A (en) 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
US20030032579A1 (en) 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
IL149106A0 (en) 2001-04-20 2002-11-10 Pfizer Prod Inc Therapeutic use of selective pde10 inhibitors
FR2824065A1 (fr) 2001-04-26 2002-10-31 Neuro3D Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
WO2004024705A1 (ja) 2002-09-10 2004-03-25 Takeda Pharmaceutical Company Limited ５員複素環化合物
AU2003288352A1 (en) 2002-10-30 2004-06-07 Centre National De La Recherche Scientifique (Cnrs) Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses
EP1641457B1 (en) 2003-06-30 2009-08-05 Nycomed GmbH Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
MXPA05013553A (es) 2003-06-30 2006-03-09 Altana Pharma Ag Pirrolodihidroisoquinolinas como inhibidores de pde10.
EP1651251A4 (en) 2003-07-31 2008-06-18 Bayer Pharmaceuticals Corp METHOD FOR THE TREATMENT OF DIABETES AND RELATED DISEASES USING PDE 10A INHIBITORS
EP1723134A2 (en) 2004-02-18 2006-11-22 Pfizer Products Incorporated Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
FR2870539B1 (fr) 2004-05-19 2006-08-04 Greenpharma Sa Sa Nouvelles methodes et medicaments
BRPI0511854A (pt) 2004-06-07 2008-01-15 Pfizer Prod Inc inibição de fosfodiestearase 10 como tratamento para condições relacionados com a obesidade e relacionadas a sìndrome metabólica
US20060019975A1 (en) 2004-07-23 2006-01-26 Pfizer Inc Novel piperidyl derivatives of quinazoline and isoquinoline
CA2578996A1 (en) 2004-09-03 2006-03-16 Memory Pharmaceuticals Corporation 4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms
US20060183763A1 (en) * 2004-12-31 2006-08-17 Pfizer Inc Novel pyrrolidyl derivatives of heteroaromatic compounds
MX2008010668A (es) * 2006-02-21 2008-10-01 Amgen Inc Derivados de cinolina como inhibidores de fosfodiesterasa 10.
TWI501965B (zh) 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物

Also Published As

Publication number Publication date
CA2765750A1 (en) 2010-12-23
ES2527216T3 (es) 2015-01-21
HRP20141222T1 (hr) 2015-02-27
WO2010145668A1 (en) 2010-12-23
AU2010262190A1 (en) 2012-01-19
SG176680A1 (en) 2012-01-30
AR077144A1 (es) 2011-08-03
MY156785A (en) 2016-03-31
CY1115971T1 (el) 2017-01-25
ZA201109271B (en) 2013-02-27
GT201100322A (es) 2014-02-06
MA33367B1 (fr) 2012-06-01
JP5768044B2 (ja) 2015-08-26
JP2012530086A (ja) 2012-11-29
SI2443105T1 (sl) 2015-02-27
GEP20146100B (en) 2014-05-27
UA106378C2 (ru) 2014-08-26
PL2443105T3 (pl) 2015-03-31
CR20110654A (es) 2012-03-09
EP2443105A1 (en) 2012-04-25
IL216684A0 (en) 2012-02-29
PT2443105E (pt) 2015-01-14
DOP2011000397A (es) 2012-07-15
TW201100430A (en) 2011-01-01
SMT201500003B (it) 2015-03-05
BRPI1015983A2 (pt) 2016-04-19
MX2011013400A (es) 2012-02-21
DK2443105T3 (en) 2015-01-12
EP2443105B1 (en) 2014-10-29
AU2010262190B2 (en) 2013-01-31
HK1171446A1 (en) 2013-03-28
NZ597203A (en) 2013-03-28

Similar Documents

Publication Publication Date Title
ZA201101701B (en) Pyrrolo[2,3-d]pyrimidine compounds
DK3178819T3 (en) 5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-carboxamider som jak-inhibitorer
ZA201202718B (en) Pyrrolo[2,3-d]pyrimidine compounds
IL196207A0 (en) Fused pyrimido compounds
GB2492275B (en) Stable narrow vehicle
IL226486A0 (en) Converted pyrazolopyrimidine compounds
IL185092A0 (en) Pyrazolopyrimidines
ZA201002334B (en) Imidazo
AU304160S (en) Four wheeled vehicle
IL194584A0 (en) Imidazo compounds
SI1982702T1 (sl) Farmacevtska oblika sirolimusa
ZA201101550B (en) 4-amino-3-(imidazolyl)-pyrazolo[3,4-d]pyrimidines
IL210171A0 (en) Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
BRPI0822239A2 (pt) Composto de pirazolo[1,5-a] pirimidina
GB0514889D0 (en) Oligonucleotides
IL206666A0 (en) N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-
EP2511276A4 (en) Pyrrolo [2,3-D] pyrimidine derivative
GB2450726B (en) Cupholders
GB0810774D0 (en) Vehicle
EP2036161A4 (en) 3D ANTENNA
GB0512545D0 (en) Studded pram tyre fitment
AU4450P (en) Amber Velvet Anigozanthos hybrid
AP2789A (en) Vehicle tracking
GB2437501B (en) Orthogonal 3D wheel
HK1130774A (en) Fused pyrimido compounds

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed