SMT201400030B - Profarmaci del dolutegravir - Google Patents
Profarmaci del dolutegravirInfo
- Publication number
- SMT201400030B SMT201400030B SM201400030T SM201400030T SMT201400030B SM T201400030 B SMT201400030 B SM T201400030B SM 201400030 T SM201400030 T SM 201400030T SM 201400030 T SM201400030 T SM 201400030T SM T201400030 B SMT201400030 B SM T201400030B
- Authority
- SM
- San Marino
- Prior art keywords
- dolutegravir
- prodrugs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8361208P | 2008-07-25 | 2008-07-25 | |
| PCT/US2009/051497 WO2010011812A1 (en) | 2008-07-25 | 2009-07-23 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201400030B true SMT201400030B (it) | 2014-05-07 |
Family
ID=41570593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201400030T SMT201400030B (it) | 2008-07-25 | 2014-03-13 | Profarmaci del dolutegravir |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8217034B2 (xx) |
| EP (1) | EP2320908B9 (xx) |
| CY (1) | CY1114981T1 (xx) |
| DK (1) | DK2320908T3 (xx) |
| ES (1) | ES2448766T3 (xx) |
| HR (1) | HRP20140223T2 (xx) |
| HU (1) | HUE020489T4 (xx) |
| PL (1) | PL2320908T3 (xx) |
| PT (1) | PT2320908E (xx) |
| SI (1) | SI2320908T1 (xx) |
| SM (1) | SMT201400030B (xx) |
| WO (1) | WO2010011812A1 (xx) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103951643B (zh) | 2008-07-25 | 2015-12-09 | 盐野义制药株式会社 | 用作hiv整合酶抑制剂的化合物 |
| KR101847887B1 (ko) | 2008-12-11 | 2018-04-11 | 시오노기세야쿠 가부시키가이샤 | 카르바모일피리돈 ｈｉｖ 인테그라제 억제제 및 중간체의 합성 |
| AU2014277831C1 (en) * | 2008-12-11 | 2022-10-06 | Shionogi & Co. Ltd. | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| US8552187B2 (en) * | 2008-12-11 | 2013-10-08 | Shionogi & Co., Ltd. | Processes and intermediates for carbamoylpyridone HIV integrase inhibitors |
| JP5629268B2 (ja) | 2008-12-11 | 2014-11-19 | 塩野義製薬株式会社 | マルトールエーテルの製造方法および中間体 |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| KR101883750B1 (ko) | 2010-01-27 | 2018-07-31 | 비이브 헬쓰케어 컴퍼니 | 항바이러스 치료 |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| WO2011129095A1 (ja) * | 2010-04-12 | 2011-10-20 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有するピリドン誘導体 |
| DK3456721T3 (da) * | 2010-08-05 | 2021-04-26 | Shionogi & Co | Fremgangsmåde til at fremstille forbindelser som har hiv-integrase-inhiberende aktivitet. |
| RU2608519C2 (ru) | 2010-09-24 | 2017-01-19 | Шионоги энд Ко. Лтд. | Пролекарственная форма замещенного полициклического производного карбамоилпиридона |
| ES2613180T3 (es) * | 2011-09-14 | 2017-05-23 | Mapi Pharma Limited | Forma amorfa de la sal sódica dolutegravir |
| SG11201504857SA (en) | 2012-12-21 | 2015-07-30 | Gilead Sciences Inc | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| WO2014128545A2 (en) | 2013-02-19 | 2014-08-28 | Aurobindo Pharma Limited | An improved process for the preparation of dolutegravir |
| WO2014200880A1 (en) | 2013-06-13 | 2014-12-18 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| WO2015001572A2 (en) * | 2013-07-04 | 2015-01-08 | Hetero Research Foundation | Process for the preparation of intermediate of dolutegravir |
| NO2865735T3 (xx) | 2013-07-12 | 2018-07-21 | ||
| CA2916993C (en) | 2013-07-12 | 2019-01-15 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| US9856270B2 (en) * | 2013-07-17 | 2018-01-02 | Ratiopharm Gmbh | Dolutegravir salts |
| EP3096763B1 (en) | 2014-01-21 | 2019-12-25 | Laurus Labs Limited | Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof |
| TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (xx) | 2014-06-20 | 2018-06-23 | ||
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| WO2016102078A1 (en) | 2014-12-24 | 2016-06-30 | Ratiopharm Gmbh | Solid state forms of dolutegravir sodium |
| PL3277691T3 (pl) | 2015-04-02 | 2019-07-31 | Gilead Sciences, Inc. | Policykliczne związki karbamoilopirydonowe i ich zastosowanie farmaceutyczne |
| JP7160466B2 (ja) * | 2016-06-23 | 2022-10-25 | ヴィーブ ヘルスケア カンパニー | 治療薬の送達のための組成物及び方法 |
| CN106360086B (zh) * | 2016-09-23 | 2020-06-30 | 皖西学院 | 一种皖西白鹅种鹅专用饲料组合物、制备方法及使用方法 |
| CN108250215B (zh) * | 2016-12-28 | 2022-04-19 | 华创合成制药股份有限公司 | 一种新型抗hiv药物及其制备方法和用途 |
| US10786488B2 (en) | 2017-01-26 | 2020-09-29 | Merck Sharp & Dohme Corp. | Substituted quinolizine derivatives useful as HIV integrase inhibitors |
| AR113748A1 (es) | 2017-10-06 | 2020-06-10 | Shionogi & Co | Proceso estereoselectivo para preparar derivados de piridona policíclicos sustituidos |
| PL3938047T3 (pl) | 2019-03-22 | 2022-11-07 | Gilead Sciences, Inc. | Zmostkowane tricykliczne związki karbamoilopirydonowe i ich zastosowanie farmaceutyczne |
| WO2021173522A1 (en) | 2020-02-24 | 2021-09-02 | Gilead Sciences, Inc. | Tetracyclic compounds for treating hiv infection |
| WO2022107755A1 (ja) | 2020-11-17 | 2022-05-27 | 塩野義製薬株式会社 | 新規アクリジニウム塩およびその製造方法 |
| PT4196479T (pt) | 2021-01-19 | 2024-01-03 | Gilead Sciences Inc | Compostos de piridotriazinas substituídos e suas utilizações |
| WO2023183472A1 (en) * | 2022-03-23 | 2023-09-28 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and use thereof |
| WO2023197017A1 (en) | 2022-04-04 | 2023-10-12 | University Of The Witwatersrand, Johannesburg | Enantioselective methods for preparing chiral amine intermediates |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1742642E (pt) | 2004-04-14 | 2009-01-23 | Gilead Sciences Inc | Análogos de fosfonato de compostos inibidores da integrase do hiv |
| US7858788B2 (en) | 2005-02-21 | 2010-12-28 | Shionogi & Co., Ltd. | Bicyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
| PT3284520T (pt) * | 2005-04-28 | 2019-09-10 | Shionogi & Co | Derivado policíclico de carbamoílpiridona possuindo atividade inibidora de integrase do hiv |
| US20070072831A1 (en) * | 2005-05-16 | 2007-03-29 | Gilead Sciences, Inc. | Integrase inhibitor compounds |
-
2009
- 2009-07-23 ES ES09800989.7T patent/ES2448766T3/es active Active
- 2009-07-23 DK DK09800989.7T patent/DK2320908T3/en active
- 2009-07-23 HU HUE09800989A patent/HUE020489T4/hu unknown
- 2009-07-23 US US13/054,633 patent/US8217034B2/en active Active
- 2009-07-23 SI SI200930888T patent/SI2320908T1/sl unknown
- 2009-07-23 PT PT98009897T patent/PT2320908E/pt unknown
- 2009-07-23 PL PL09800989T patent/PL2320908T3/pl unknown
- 2009-07-23 EP EP09800989.7A patent/EP2320908B9/en active Active
- 2009-07-23 WO PCT/US2009/051497 patent/WO2010011812A1/en active Application Filing
-
2014
- 2014-03-11 HR HRP20140223AT patent/HRP20140223T2/hr unknown
- 2014-03-13 SM SM201400030T patent/SMT201400030B/xx unknown
- 2014-03-18 CY CY20141100217T patent/CY1114981T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20140223T2 (hr) | 2014-08-01 |
| PT2320908E (pt) | 2014-03-06 |
| EP2320908B1 (en) | 2013-12-25 |
| DK2320908T3 (en) | 2014-03-10 |
| US20110190236A1 (en) | 2011-08-04 |
| CY1114981T1 (el) | 2016-12-14 |
| US8217034B2 (en) | 2012-07-10 |
| WO2010011812A1 (en) | 2010-01-28 |
| ES2448766T3 (es) | 2014-03-17 |
| HUE020489T4 (hu) | 2016-01-28 |
| PL2320908T3 (pl) | 2014-06-30 |
| EP2320908A4 (en) | 2011-10-26 |
| EP2320908A1 (en) | 2011-05-18 |
| ES2448766T9 (es) | 2014-09-05 |
| SI2320908T1 (sl) | 2014-05-30 |
| HRP20140223T1 (xx) | 2014-04-11 |
| EP2320908B9 (en) | 2014-06-18 |
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