PL2320908T3 - Proleki dolutegrawiru - Google Patents
Proleki dolutegrawiruInfo
- Publication number
- PL2320908T3 PL2320908T3 PL09800989T PL09800989T PL2320908T3 PL 2320908 T3 PL2320908 T3 PL 2320908T3 PL 09800989 T PL09800989 T PL 09800989T PL 09800989 T PL09800989 T PL 09800989T PL 2320908 T3 PL2320908 T3 PL 2320908T3
- Authority
- PL
- Poland
- Prior art keywords
- dolutegravir
- prodrugs
- dolutegravir prodrugs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8361208P | 2008-07-25 | 2008-07-25 | |
| EP09800989.7A EP2320908B9 (en) | 2008-07-25 | 2009-07-23 | Dolutegravir Prodrugs |
| PCT/US2009/051497 WO2010011812A1 (en) | 2008-07-25 | 2009-07-23 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2320908T3 true PL2320908T3 (pl) | 2014-06-30 |
Family
ID=41570593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09800989T PL2320908T3 (pl) | 2008-07-25 | 2009-07-23 | Proleki dolutegrawiru |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8217034B2 (pl) |
| EP (1) | EP2320908B9 (pl) |
| CY (1) | CY1114981T1 (pl) |
| DK (1) | DK2320908T3 (pl) |
| ES (1) | ES2448766T3 (pl) |
| HR (1) | HRP20140223T2 (pl) |
| HU (1) | HUE020489T4 (pl) |
| PL (1) | PL2320908T3 (pl) |
| PT (1) | PT2320908E (pl) |
| SI (1) | SI2320908T1 (pl) |
| SM (1) | SMT201400030B (pl) |
| WO (1) | WO2010011812A1 (pl) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG192550A1 (en) | 2008-07-25 | 2013-08-30 | Viiv Healthcare Co | Chemical compounds |
| EP2376453B1 (en) | 2008-12-11 | 2019-11-20 | VIIV Healthcare Company | Intermediates for carbamoylpyridone hiv integrase inhibitors |
| US8710249B2 (en) | 2008-12-11 | 2014-04-29 | Shionogi & Co., Ltd. | Maltol ether processes and intermediates |
| EP2376080B1 (en) | 2008-12-11 | 2017-09-13 | Shionogi&Co., Ltd. | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| AU2014277831C1 (en) * | 2008-12-11 | 2022-10-06 | Shionogi & Co. Ltd. | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| EA032868B1 (ru) | 2010-01-27 | 2019-07-31 | Вайв Хелткер Компани | Комбинация для лечения вич-инфекции |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| US9216995B2 (en) | 2010-04-12 | 2015-12-22 | Shionogi & Co., Ltd. | Pyridone derivative having integrase inhibitory activity |
| ES2608377T3 (es) | 2010-08-05 | 2017-04-10 | Shionogi & Co., Ltd. | Procedimiento de preparación de un compuesto que tiene actividad inhibidora de la integrasa del HIV |
| CN103228653B (zh) * | 2010-09-24 | 2016-03-16 | 盐野义制药株式会社 | 被取代的多环性氨基甲酰基吡啶酮衍生物的前药 |
| EP2742051B1 (en) * | 2011-09-14 | 2016-10-12 | Mapi Pharma Limited | Amorpous form of the dolutegravir sodium salt |
| MX344879B (es) | 2012-12-21 | 2017-01-11 | Gilead Sciences Inc | Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico. |
| US9573965B2 (en) | 2013-02-19 | 2017-02-21 | Aurobindo Pharma Ltd | Process for the preparation of Dolutegravir |
| US9951079B2 (en) | 2013-06-13 | 2018-04-24 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as HIV integrase inhibitors |
| WO2015001572A2 (en) * | 2013-07-04 | 2015-01-08 | Hetero Research Foundation | Process for the preparation of intermediate of dolutegravir |
| LT3019503T (lt) | 2013-07-12 | 2017-11-27 | Gilead Sciences, Inc. | Policikliniai karbamoilpiridono junginiai ir jų panaudojimas živ infekcijų gydymui |
| NO2865735T3 (pl) | 2013-07-12 | 2018-07-21 | ||
| WO2015009927A1 (en) * | 2013-07-17 | 2015-01-22 | Ratiopharm Gmbh | Dolutegravir salts |
| WO2015110897A2 (en) | 2014-01-21 | 2015-07-30 | Laurus Labs Private Limited | Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof |
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| NO2717902T3 (pl) | 2014-06-20 | 2018-06-23 | ||
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| TWI738321B (zh) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| WO2016102078A1 (en) | 2014-12-24 | 2016-06-30 | Ratiopharm Gmbh | Solid state forms of dolutegravir sodium |
| CA2980362C (en) | 2015-04-02 | 2020-02-25 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| WO2017223280A2 (en) * | 2016-06-23 | 2017-12-28 | Viiv Healthcare Company | Compositions and methods for the delivery of therapeutics |
| CN106360086B (zh) * | 2016-09-23 | 2020-06-30 | 皖西学院 | 一种皖西白鹅种鹅专用饲料组合物、制备方法及使用方法 |
| CN108250215B (zh) * | 2016-12-28 | 2022-04-19 | 华创合成制药股份有限公司 | 一种新型抗hiv药物及其制备方法和用途 |
| EP3573984A4 (en) * | 2017-01-26 | 2020-07-29 | Merck Sharp & Dohme Corp. | USEFUL SUBSTITUTE QUINOLIZINE DERIVATIVES AS HIV INTEGRASE INHIBITORS |
| RU2755710C2 (ru) | 2017-06-30 | 2021-09-20 | Вайв Хелткер Компани | Комбинация, ее применение и способы лечения с использованием указанной комбинации |
| CN111386276B (zh) | 2017-10-06 | 2023-06-23 | 盐野义制药株式会社 | 制备取代的多环吡啶酮衍生物的立体选择性方法 |
| SI3938047T1 (sl) | 2019-03-22 | 2022-10-28 | Gilead Sciences, Inc. | Premoščene triciklične karbamoilpiridonske spojine in njihova farmacevtska uporaba |
| WO2021173522A1 (en) | 2020-02-24 | 2021-09-02 | Gilead Sciences, Inc. | Tetracyclic compounds for treating hiv infection |
| KR20230079137A (ko) | 2020-09-30 | 2023-06-05 | 길리애드 사이언시즈, 인코포레이티드 | 가교된 트리사이클릭 카르바모일피리돈 화합물 및 이의 용도 |
| EP4249077A4 (en) | 2020-11-17 | 2025-02-12 | Shionogi & Co., Ltd | NEW ACRIDINIUM SALT AND METHOD FOR THE PRODUCTION THEREOF |
| PT4196479T (pt) | 2021-01-19 | 2024-01-03 | Gilead Sciences Inc | Compostos de piridotriazinas substituídos e suas utilizações |
| JP2024507788A (ja) * | 2021-02-16 | 2024-02-21 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｈｉｖインテグラーゼ阻害剤として有用な四環式複素環化合物 |
| WO2023183472A1 (en) * | 2022-03-23 | 2023-09-28 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and use thereof |
| EP4493708A1 (en) | 2022-04-04 | 2025-01-22 | University of the Witwatersrand, Johannesburg | Enantioselective methods for preparing chiral amine intermediates |
| TWI856796B (zh) | 2022-04-06 | 2024-09-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| WO2025080863A1 (en) | 2023-10-11 | 2025-04-17 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| US20250127801A1 (en) | 2023-10-11 | 2025-04-24 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005010413D1 (de) * | 2004-04-14 | 2008-11-27 | Zhenhong R Cai | Phosphonatanaloga von hiv-integrasehemmerverbindungen |
| JP5317257B2 (ja) * | 2005-02-21 | 2013-10-16 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体 |
| US8129385B2 (en) * | 2005-04-28 | 2012-03-06 | Shionogi & Co., Ltd. | Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness |
| TW200716632A (en) * | 2005-05-16 | 2007-05-01 | Gilead Sciences Inc | Integrase inhibitor compounds |
-
2009
- 2009-07-23 ES ES09800989.7T patent/ES2448766T3/es active Active
- 2009-07-23 WO PCT/US2009/051497 patent/WO2010011812A1/en not_active Ceased
- 2009-07-23 DK DK09800989.7T patent/DK2320908T3/en active
- 2009-07-23 HR HRP20140223AT patent/HRP20140223T2/hr unknown
- 2009-07-23 PT PT98009897T patent/PT2320908E/pt unknown
- 2009-07-23 SI SI200930888T patent/SI2320908T1/sl unknown
- 2009-07-23 EP EP09800989.7A patent/EP2320908B9/en active Active
- 2009-07-23 US US13/054,633 patent/US8217034B2/en active Active
- 2009-07-23 PL PL09800989T patent/PL2320908T3/pl unknown
- 2009-07-23 HU HUE09800989A patent/HUE020489T4/hu unknown
-
2014
- 2014-03-13 SM SM201400030T patent/SMT201400030B/xx unknown
- 2014-03-18 CY CY20141100217T patent/CY1114981T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20140223T1 (en) | 2014-04-11 |
| EP2320908B1 (en) | 2013-12-25 |
| HRP20140223T2 (hr) | 2014-08-01 |
| CY1114981T1 (el) | 2016-12-14 |
| US20110190236A1 (en) | 2011-08-04 |
| US8217034B2 (en) | 2012-07-10 |
| EP2320908A1 (en) | 2011-05-18 |
| EP2320908B9 (en) | 2014-06-18 |
| PT2320908E (pt) | 2014-03-06 |
| SI2320908T1 (sl) | 2014-05-30 |
| EP2320908A4 (en) | 2011-10-26 |
| WO2010011812A1 (en) | 2010-01-28 |
| DK2320908T3 (en) | 2014-03-10 |
| SMT201400030B (it) | 2014-05-07 |
| ES2448766T9 (es) | 2014-09-05 |
| ES2448766T3 (es) | 2014-03-17 |
| HUE020489T4 (hu) | 2016-01-28 |
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