SK702003A3 - A process for lactonization to produce simvastatin - Google Patents

A process for lactonization to produce simvastatin Download PDF

Info

Publication number
SK702003A3
SK702003A3 SK70-2003A SK702003A SK702003A3 SK 702003 A3 SK702003 A3 SK 702003A3 SK 702003 A SK702003 A SK 702003A SK 702003 A3 SK702003 A3 SK 702003A3
Authority
SK
Slovakia
Prior art keywords
lactonization
simvastatin
reaction
minutes
product
Prior art date
Application number
SK70-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Dandala Ramesh
Sebastian Sonny
Jagan Mohan Reddy Sanapureddy
Sunderam Sivakumaran Meenakshi
Original Assignee
Aurobindo Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurobindo Pharma Ltd filed Critical Aurobindo Pharma Ltd
Publication of SK702003A3 publication Critical patent/SK702003A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK70-2003A 2001-05-18 2002-05-16 A process for lactonization to produce simvastatin SK702003A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN401CH2001 2001-05-18
PCT/IN2002/000122 WO2002094804A1 (en) 2001-05-18 2002-05-16 A process for lactonization to produce simvastatin

Publications (1)

Publication Number Publication Date
SK702003A3 true SK702003A3 (en) 2003-12-02

Family

ID=11097002

Family Applications (1)

Application Number Title Priority Date Filing Date
SK70-2003A SK702003A3 (en) 2001-05-18 2002-05-16 A process for lactonization to produce simvastatin

Country Status (6)

Country Link
EP (1) EP1294706A1 (sl)
JP (1) JP2004520445A (sl)
BG (1) BG107475A (sl)
SI (1) SI21235A (sl)
SK (1) SK702003A3 (sl)
WO (1) WO2002094804A1 (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100423892B1 (ko) * 2001-12-03 2004-03-22 씨제이 주식회사 스타틴의 제조에 있어서 새로운 락톤화 방법
WO2005012279A1 (en) * 2003-08-04 2005-02-10 Biocon Limited Lactonization process
DE602004017784D1 (de) 2004-03-30 2008-12-24 Lupin Ltd Verbessertes verfahren zur herstellung von 4-hydroxypyran-2-onderivaten
WO2007125547A2 (en) 2006-05-03 2007-11-08 Manne Satyanarayana Reddy Novel process for statins and its pharmaceutically acceptable salts thereof
US8404841B2 (en) 2006-10-09 2013-03-26 Msn Laboratories Limited Process for the preparation of statins and their pharmaceutically acceptable salts thereof
WO2010089770A2 (en) 2009-01-19 2010-08-12 Msn Laboratories Limited Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
WO2011086584A2 (en) 2010-01-18 2011-07-21 Msn Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
ZA9810764B (en) * 1998-04-22 1999-08-13 Ranbaxy Lab Ltd An improved process of lactonization in the preparation of statins.
EP1228057A2 (en) * 1999-10-27 2002-08-07 Merck & Co., Inc. Lactonization process

Also Published As

Publication number Publication date
EP1294706A1 (en) 2003-03-26
BG107475A (bg) 2004-01-30
JP2004520445A (ja) 2004-07-08
SI21235A (sl) 2003-12-31
WO2002094804A1 (en) 2002-11-28

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Legal Events

Date Code Title Description
FB9A Suspension of patent application procedure